Results 11 to 20 of about 4,777,996 (166)

Improved cell line IPEC-J2, characterized as a model for porcine jejunal epithelium. [PDF]

PLoS ONE, 2013
Cell lines matching the source epithelium are indispensable for investigating porcine intestinal transport and barrier properties on a subcellular or molecular level and furthermore help to reduce animal usage.
Silke S Zakrzewski, Jan F Richter, Susanne M Krug, Britta Jebautzke, In-Fah M Lee, Juliane Rieger, Monika Sachtleben, Angelika Bondzio, Jörg D Schulzke, Michael Fromm, Dorothee Günzel   +10 more
doaj   +6 more sources

TGF-β from the Porcine Intestinal Cell Line IPEC-J2 Induced by Porcine Circovirus 2 Increases the Frequency of Treg Cells via the Activation of ERK (in CD4⁺ T Cells) and NF-κB (in IPEC-J2)

Viruses, 2022
Porcine circovirus 2 (PCV2) causes immunosuppression. Piglets infected with PCV2 can develop enteritis. Given that the gut is the largest immune organ, however, the response of the gut’s immune system to PCV2 is still unclear.
Xuewei Liu, Yang Wang, Cheng Han, Qiuming Li, Xiaolin Hou, Qinye Song, Shuanghai Zhou, Huanrong Li   +7 more
doaj   +2 more sources

Low-Molecular-Weight Chitosan Attenuates Lipopolysaccharide-Induced Inflammation in IPEC-J2 Cells by Inhibiting the Nuclear Factor-κB Signalling Pathway

Molecules, 2021
Low-molecular-weight chitosan (LMWC), a product of chitosan deacetylation, possesses anti-inflammatory effects. In the present study, a porcine small intestinal epithelial cell line, IPEC-J2, was used to assess the protective effects of LMWC on ...
Jiao Zhang, Jin Wan, Daiwen Chen, Bing Yu, Jun He   +4 more
doaj   +2 more sources

Inhibition of Enterotoxigenic Escherichia coli adhesion via aptamers prevents infection in IPEC-J2 cells

BMC Microbiology
Enterotoxigenic Escherichia coli (ETEC) is a well-known strain associated with post-weaning diarrhea. Consequently, strategies to prevent and inhibit ETEC infections are critically important. Aptamers are single-stranded DNA or RNA sequences that exhibit
Zefeng Wang, Tao Xu, Jianxi Tan, Yan Zhou, Qiyi Li, Zhihui Peng   +5 more
doaj   +2 more sources

Protective Effects of L-Theanine on IPEC-J2 Cells Growth Inhibition Induced by Dextran Sulfate Sodium via p53 Signaling Pathway

Molecules, 2021
L-theanine is a nonprotein amino acid found in tea leaves and has been widely used as a safe food additive in beverages or foods because of its varied bioactivities.
Longlin Zhang, Mengmeng Ma, Zhengyi Li, Haihan Zhang, Xi He, Zehe Song   +5 more
doaj   +2 more sources

Lack of LTβR Increases Susceptibility of IPEC-J2 Cells to Porcine Epidemic Diarrhea Virus [PDF]

Cells, 2018
The essential requirement of the lymphotoxin beta receptor (LTβR) in the development and maintenance of peripheral lymphoid organs is well recognized. Evidence shows that LTβR is involved in various cellular processes; however, whether it plays
Kui Li, Yanfang Wang, Tawfeek Altawaty, Lulu Liu, Hongyong Zhang, Cong Tao, Shaohua Hou   +6 more
core   +4 more sources

Genistein Alleviates Intestinal Oxidative Stress by Activating the Nrf2 Signaling Pathway in IPEC-J2 Cells

Veterinary Sciences
In the weaning period, piglets often face oxidative stress, which will cause increased diarrhea and mortality. Genistein, a flavonoid, which is extracted from leguminous plants, possesses anti-inflammatory and antioxidative bioactivities. However, little
Yanpin Li, Long Cai, Qingyue Bi, Wenjuan Sun, Yu Pi, Xianren Jiang, Xilong Li   +6 more
doaj   +2 more sources

Naringenin Inhibits Enterotoxigenic Escherichia coli-Induced Ferroptosis via Targeting HSP90 in IPEC-J2 Cells

Antioxidants
Enterotoxigenic Escherichia coli (ETEC) leads to severe diarrhea in piglets. Naringenin (Nar), a natural flavonoid compound, is known for its antibacterial and anti-antioxidant properties.
Pengxin Jiang, Kangping Liu, Yanan Cui, Puyu Liu, Xutao Wang, Zijuan Hou, Jiamei Cui, Ning Chen, Jinghui Fan, Jianguo Li, Yuzhu Zuo, Yan Li   +11 more
doaj   +2 more sources

Effects of daidzein on antioxidant capacity in weaned pigs and IPEC-J2 cells

Animal Nutrition, 2022
Our previous study found that soybean isoflavones in soybean meal play an important role in improving growth performance and antioxidant capacity in pigs. However, it is still unknown whether long-term supplementation with daidzein, an active molecule deglycosylated from daidzin, in a corn-soybean meal diet can enhance growth performance in pigs. Thus,
Yanpin Li, Xianren Jiang, Long Cai, Yanli Zhang, Hongbiao Ding, Jingdong Yin, Xilong Li   +6 more
openaire   +3 more sources

A Medium-Throughput System for In Vitro Oxidative Stress Assessment in IPEC-J2 Cells [PDF]

International Journal of Molecular Sciences, 2020
The feed industry continuously seeks new molecules with antioxidant capacity since oxidative stress plays a key role in intestinal health. To improve screening of new antioxidants, this study aims to set up an assay to assess oxidative stress in the porcine small intestinal epithelial cell line IPEC-J2 using plate-reader-based analysis of fluorescence.
Miriam Ayuso, Steven Van Cruchten, Chris Van Ginneken   +2 more
openaire   +3 more sources