Results 91 to 100 of about 15,094 (184)

Production of the High Value Pharmaceutical Target, Human Granulocyte‐Colony Stimulating Factor, in Nicotiana benthamiana Is Improved by Co‐Expression of the Transcriptional Regulator of the Unfolded Protein Response, bZIP60

Plant Biotechnology Journal, EarlyView.
Nazgul Wagner, Konstantin Musiychuk, Stephen Tottey, Jukka Kervinen, Hong Bi, Stephen J. Streatfield, Rainer Fischer, Vidadi Yusibov   +7 more
wiley   +1 more source

IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin

Molecular Biology of the Cell, 2012
Endoplasmic reticulum (ER) is responsible for folding of secreted and membrane proteins in eukaryotic cells. Disruption of ER protein folding leads to ER stress. Chronic ER stress can cause cell death and is proposed to underlie the pathogenesis of many human diseases. Inositol-requiring enzyme 1 (IRE1) directs a key unfolded protein response signaling
Chiang, Wei-Chieh, Messah, Carissa, Lin, Jonathan H.   +2 more
openaire   +2 more sources

Computer-aided peptide-based drug design for inositol-requiring enzyme 1

Basic & Clinical Cancer Research, 2023
Inositol-requiring enzyme 1 (IRE1), an endoplasmic reticulum (ER) transmembrane protein with both kinase and endoribonuclease activities, plays an essential role during ER stress and its subsequent unfolded protein response (UPR).
Alireza Ghanbari, Amir Norouzy, Negar Balmeh, Najaf Allahyari Fard, Mohammad Amin Moosavi   +4 more
doaj  

Intestinal IRE1 Is Required for Increased Triglyceride Metabolism and Longer Lifespan under Dietary Restriction

Cell Reports, 2016
Summary: Dietary restriction (DR) is one of the most robust lifespan-extending interventions in animals. The beneficial effects of DR involve a metabolic adaptation toward increased triglyceride usage.
Nuno Miguel Luis, Lifen Wang, Mauricio Ortega, Hansong Deng, Subhash D. Katewa, Patrick Wai-Lun Li, Jason Karpac, Heinrich Jasper, Pankaj Kapahi   +8 more
doaj   +1 more source

Tweaking Ire1 to Unlock Autophagy in Yeast

Autophagy Reports, 2023
Eshita Das, Ipsita Roy
openaire   +3 more sources

IRE1: a role in UPREgulation of ER degradation.

Developmental cell, 2003
The unfolded protein response entered the mechanistic realm with the discovery of IRE1 as the key signal transducer in yeast. Although also found in mammals, it appeared to function in assisting the work of other players. The featured studies indicate a separate role for IRE1, and highlight the flexibility that bigger eukaryotes possess in this ...
openaire   +2 more sources

IRE1 [PDF]

Developmental Cell, 2003
openaire   +1 more source

Tongguanteng injection exerts anti-osteosarcoma effects through the ER stress-associated IRE1/CHOP pathway

BMC Complementary Medicine and Therapies
Background In China, Tongguanteng injection (TGT) is widely used in the treatment or adjuvant treatment of various types of cancer. However, the effect and mechanism of TGT in osteosarcoma is not clear.
Xiao-Chuan Xue, Yang-Yun Zhou, Ling-Yan Xu, Lan-Yi Wei, Yu-Jie Hu, Jiao Yang, Xiang-Qi Zhang, Meng-Yue Wang, Yong-Long Han, Jun-Jun Chen   +9 more
doaj   +1 more source

IRE1-mediated cytoplasmic splicing and regulated IRE1-dependent decay of mRNA in the liverwort Marchantia polymorpha.

Plant biotechnology (Tokyo, Japan)
The unfolded protein response (UPR) or the endoplasmic reticulum (ER) stress response is a homeostatic cellular response conserved in eukaryotes to alleviate the accumulation of unfolded proteins in the ER. In the present study, we characterized the UPR in the liverwort Marchantia polymorpha to obtain insights into the conservation and divergence of ...
Sho, Takeda, Taisuke, Togawa, Kei-Ichiro, Mishiba, Katsuyuki T, Yamato, Yuji, Iwata, Nozomu, Koizumi   +5 more
openaire   +1 more source

Immunohistochemical Expression of Endoplasmic Reticulum Stress Markers and their Association With Clinicopathological Characteristics and Survival Outcomes in Endometrial Cancer. [PDF]

Cancer Diagn Progn
Flindris S, Margioula-Siarkou C, Gouta C, Christopoulos K, Margioula-Siarkou G, Almperi EA, Almperis A, Traianos A, Kalinderis M, Sakellariou E, Flindris K, Karachalios C, Styliara E, Angelidou S, Pantazis K, Navrozoglou I, Dinas K, Markozannes G, Petousis S.   +18 more
europepmc   +1 more source