Results 11 to 20 of about 15,094 (184)
A novel IRE1 kinase inhibitor for adjuvant glioblastoma treatment
iScience, 2023 Summary: Inositol-requiring enzyme 1 (IRE1) is a major mediator of the unfolded protein response (UPR), which is activated upon endoplasmic reticulum (ER) stress.
Diana Pelizzari-Raymundo +13 more
doaj +4 more sources
Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay [PDF]
Nature Communications, 2022 In Drosophila, ER-targeted mRNAs are degraded by Ire1-dependent pathway. Here the authors report that the fly mRNA binding protein Pumilio is phosphorylated by Ire1 and binds to Xbp1 mRNA, protecting it from the non-canonical endoribonuclease activity of
Fátima Cairrão +5 more
doaj +3 more sources
Pharmacological Targeting of IRE1 in Cancer [PDF]
Trends in Cancer, 2020 IRE1α (inositol requiring enzyme 1 alpha) is one of the main transducers of the unfolded protein response (UPR). IRE1α plays instrumental protumoral roles in several cancers, and high IRE1α activity has been associated with poorer prognoses. In this context, IRE1α has been identified as a potentially relevant therapeutic target.
Raymundo, Diana Pelizzari +5 more
openaire +4 more sources
Intercepting IRE1 kinase‐FMRP signaling prevents atherosclerosis progression [PDF]
EMBO Molecular Medicine, 2022 ISSN:1757 ...
Zehra Yildirim +17 more
openaire +7 more sources
Quaternary structure analysis of IRE1
microPublication biology, 2023 IRE1 belongs to a type I transmembrane protein family harboring two functional domains, cytoplasmic domain with kinase and RNAse catalytic activity, and the luminal domain, which is involved in the sensing of unfolded proteins. IRE1 molecule undergoes dimerization in the lumenal domain, which functionally activates the catalytic C-terminal domain. IRE1
Bashir, Samirul +4 more
openaire +2 more sources
Inflammation promotes adipocyte lipolysis via IRE1 kinase [PDF]
Journal of Biological Chemistry, 2020 AbstractObesity associates with inflammation, insulin resistance and higher blood lipids. It is unclear if immune responses facilitate lipolysis separate from hormone or adrenergic signals. We found that an ancient component of ER stress, inositol-requiring protein 1 (IRE1), discriminates inflammation-induced adipocyte lipolysis versus lipolysis ...
Kevin P. Foley +10 more
openaire +3 more sources
How IRE1 Reacts to ER Stress [PDF]
Cell, 2008 The long-awaited structure of the effector portion of IRE1, the endoplasmic reticulum stress transducer, is published in this issue of Cell (Lee et al., 2008). This structure provides new insight into the mysterious coupling of kinase and endoribonuclease activities in the oldest, most-conserved branch of the unfolded protein response in eukaryotes.
Ron, David, Hubbard, Stevan R.
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Phosphoregulation of Ire1 RNase splicing activity [PDF]
Nature Communications, 2014 AbstractIre1 is activated in response to accumulation of misfolded proteins within the endoplasmic reticulum as part of the unfolded protein response (UPR). It is a unique enzyme, possessing both kinase and RNase activity that is required for specific splicing of Xbp1 mRNA leading to UPR activation.
Prischi, Filippo +3 more
openaire +4 more sources
Physiological roles of regulated Ire1 dependent decay [PDF]
Frontiers in Genetics, 2014 Inositol-requiring enzyme 1 (Ire1) is an important transducer of the unfolded protein response (UPR) that is activated by the accumulation of misfolded proteins in the endoplamic reticulum (ER stress). Activated Ire1 mediates the splicing of an intron from the mRNA of Xbp1, causing a frame-shift during translation and introducing a new carboxyl domain ...
Dina S. Coelho, Pedro M. Domingos
openaire +3 more sources
IRE1-MEDIATED IMMUNOMODULATION IN GLIOBLASTOMA [PDF]
Neuro-Oncology, 2016 Conference: 12th Meeting of the European-Association-of-Neuro-Oncology Location: GERMANY Date: OCT 12-16, 2016 - Meeting Abstract: OS1 ...
Lhomond, S. +9 more
openaire +2 more sources