Ire1 inhibition - Open Access .click

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Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo

Cancer Letters, 2020
International audienceGlioblastoma multiforme (GBM) is the most severe primary brain cancer. Despite an aggressive treatment comprising surgical resection and radio/chemotherapy, patient's survival post diagnosis remains short.
Eric Chevet +2 more
exaly +3 more sources

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glioma cells
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Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition

Acta Pharmacologica Sinica, 2022
Yu-Bo Zhou, Chang-Mei Liu, An-Hui Gao
exaly

Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo

Biochemical Pharmacology, 2022
Honglei Kang, Yu Kaixu
exaly

Inhibition of ER stress by targeting the IRE1α–TXNDC5 pathway alleviates crystalline silica-induced pulmonary fibrosis

International Immunopharmacology, 2021
Chao Li, Jiali Liu
exaly

KIRA8 attenuates non-alcoholic steatohepatitis through inhibition of the IRE1α/XBP1 signalling pathway

Biochemical and Biophysical Research Communications, 2022
Xiaoyan Hui, Kerry Loomes, Lei Li
exaly