Results 51 to 60 of about 81,945 (302)

Functional analysis of a dominant negative mutation of interferon regulatory factor 5. [PDF]

PLoS ONE, 2009
BACKGROUND: Interferon regulatory factor (IRF) family members have been implicated as critical transcription factors that function in immune response, hematopoietic differentiation and cell growth regulation. Activation of IRF-5 results in the production
Long Yang, Tiejun Zhao, Xiaoliu Shi, Peyman Nakhaei, Yunling Wang, Qiang Sun, John Hiscott, Rongtuan Lin   +7 more
doaj   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

IRF-7 activation by the PapG adhesin.

, 2019
A. Increase in IRF-7 protein levels after infection of human kidney cells with E. coli 83972pap but not E. coli 83972fim (105 cfu/ml, 4 hours). Western blot analysis. B. Increase in nuclear and total IRF-7 staining, quantified by confocal imaging. Mean +
Ulrich Dobrindt (241399), Björn Wullt (243099), Jenny Grönberg-Hernández (6818597), Scott J. Hultgren (243893), Christoph Stork (5448281), Bela Köves (6818600), Daniel S. C. Butler (3211722), Ines Ambite (3211713), Jaroslaw Zdziarski (243098), Jerome Pinkner (6818603), Catharina Svanborg (67921)   +10 more
core   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

A Novel Ebola Virus VP40 Matrix Protein-Based Screening for Identification of Novel Candidate Medical Countermeasures

Viruses, 2020
Filoviruses, such as Ebola virus and Marburg virus, are of significant human health concern. From 2013 to 2016, Ebola virus caused 11,323 fatalities in Western Africa.
Ryan P. Bennett, Courtney L. Finch, Elena N. Postnikova, Ryan A. Stewart, Yingyun Cai, Shuiqing Yu, Janie Liang, Julie Dyall, Jason D. Salter, Harold C. Smith, Jens H. Kuhn   +10 more
doaj   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

From Primary to Tertiary Care: Implementing the WHO Package of Interventions for Rehabilitation

Journal of the Pakistan Medical Association
Rehabilitation is an essential component of health systems, yet access to comprehensive services remains highly inequitable, particularly in low- and middleincome countries (LMICs).
Mary Elizabeth Nelson-Biersach, Abena Tannor, Yunna Sinskey, Farooq Azam Rathore   +3 more
doaj   +1 more source

IRF-7C inhibits IRF-7-mediated transactivation of IFN promoter.

, 2013
A. IRF-7C inhibits the IRF-7-mediated activation of IFN-β reporter construct. 293T cells were transfected with 0, 50, 100, and 200 ng of IRF-7C (lanes 1–4 respectively) plus IFN-β promoter reporter construct and β-gal expression plasmids.
Dongsheng Xu (84949), Yong Zhao (84950), Yanjun Jiang (84948), Luwen Zhang (84951)   +3 more
core   +1 more source

The extreme solar storm of May 1921: observations and a complex topological model [PDF]

Annales Geophysicae, 2015
A complex solid torus model was developed in order to be able to study an extreme solar storm, the so-called "Great Storm" or "New York Railroad Storm" of May 1921, when neither high spatial and time resolution magnetic field measurements, solar
H. Lundstedt, T. Persson, V. Andersson
doaj   +1 more source

IRF-3 and Bax: A deadly affair [PDF]

Cell Cycle, 2010
Comment on: Chattopadhyay S, Marques JT, Yamashita M, Peters KL, Smith K, Desai A, et al. Viral apoptosis is induced by IRF-3-mediated activation of Bax.
Saurabh, Chattopadhyay, Ganes C, Sen
openaire   +2 more sources