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Current Opinion in Clinical Nutrition & Metabolic Care, 2016
Iron is essential for normal cellular function and many diseases result from disturbances in iron homeostasis. This review describes some of the recent key advances in iron transport and its regulation, how this relates to iron-related disorders, and emerging therapies for these diseases.The iron-regulatory hormone hepcidin and its target, the iron ...
Shanshan, Guo +2 more
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Iron is essential for normal cellular function and many diseases result from disturbances in iron homeostasis. This review describes some of the recent key advances in iron transport and its regulation, how this relates to iron-related disorders, and emerging therapies for these diseases.The iron-regulatory hormone hepcidin and its target, the iron ...
Shanshan, Guo +2 more
openaire +2 more sources
Orchestration of Iron Homeostasis
New England Journal of Medicine, 2005The characterization of newly identified genes has led investigators to challenge previous models of the regulation of iron homeostasis in health and its dysregulation in disease. Drs. Robert Fleming and Bruce Bacon describe hepcidin and iron homeostasis.
Robert E, Fleming, Bruce R, Bacon
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Science's STKE, 2001
Hemochromatosis (HH) is a human disease characterized by an overload of iron in the plasma and multiple organs. The mouse model of HH is the result of a mutation in the HFE gene, which encodes a protein that interacts with the transferrin receptor.
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Hemochromatosis (HH) is a human disease characterized by an overload of iron in the plasma and multiple organs. The mouse model of HH is the result of a mutation in the HFE gene, which encodes a protein that interacts with the transferrin receptor.
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Physiological Reviews, 2013
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes.
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The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes.
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Iron species in iron homeostasis and toxicity
The Analyst, 1995Iron homeostasis in prokaryotic cells appears to be regulated essentially at the level of the genome by the Fur protein. When iron is in short supply the uptake and assimilation pathways are de-repressed and siderophores are synthesized together with the outer, inner (plasma) membrane, periplasmic and cytosolic components necessary for the uptake of ...
R R, Crichton, R J, Ward
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Iron homeostasis and organismal aging
Ageing Research Reviews, 2021Iron is indispensable for normal body functions across species because of its critical roles in red blood cell function and many essential proteins and enzymes required for numerous physiological processes. Regulation of iron homeostasis is an intricate process involving multiple modulators at the systemic, cellular, and molecular levels. Interestingly,
Rola S, Zeidan +3 more
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Iron homeostasis in chronic inflammation
Acta Physiologica Hungarica, 2007Inflammation induced anemia and resistance to erythropoietin are common features in patients with chronic kidney disease (CKD). Elevated levels of cytokines and enhanced oxidative stress, conditions associated with inflammatory states, are implicated in the development of anemia.
Balla, J. +5 more
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Revisiting Iron Metabolism, Iron Homeostasis and Iron Deficiency Anemia
Clinical Laboratory, 2021Iron deficiency anemia (IDA) is one of the commonest clinical scenarios especially in children, women of childbearing age, and elders. The crux of this review was revisiting iron homeostasis, mechanism of iron absorption, causes, laboratory diagnosis, and management of IDA.This narrative review is compiled after a relevant literature search from ...
Muhammad, Saboor +3 more
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Metabolic surgery and iron homeostasis
Obesity Reviews, 2018SummaryIron deficiency and anaemia after metabolic surgery, potentially modifiable nutritional complications, are becoming an increasing cause for concern as prevalence increases with time and there is limited evidence supporting the effectiveness of the current guidelines for prophylactic oral iron supplementation and treatment for deficiency ...
Peter N. Benotti +5 more
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Iron homeostasis in breast cancer
Cancer Letters, 2014Iron is an essential element and a critical component of molecules involved in energy production, cell cycle and intermediate metabolism. However, the same characteristic chemistry that makes it so biologically versatile may lead to iron-associated toxicity as a consequence of increased oxidative stress. The fact that free iron accumulates with age and
Oriana, Marques +3 more
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