Results 1 to 10 of about 1,583 (164)

Efficacy of radical reactions of isocyanides with heteroatom radicals in organic synthesis [PDF]

Beilstein Journal of Organic Chemistry
Isocyanide is a promising synthetic reagent not only as a one-carbon homologation reagent but also as a nitrogen source for nitrogen-containing molecules.
Akiya Ogawa, Yuki Yamamoto
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Synthesis of pyrrole-fused dibenzoxazepine/dibenzothiazepine/triazolobenzodiazepine derivatives via isocyanide-based multicomponent reactions [PDF]

Beilstein Journal of Organic Chemistry
An efficient and facile synthesis of pyrrole-fused dibenzoxazepine/dibenzothiazepine/triazolobenzodiazepine derivatives was developed through the isocyanide-based multicomponent reaction of isocyanides, gem-diactivated olefins, and cyclic imines such as ...
Marzieh Norouzi, Mohammad Taghi Nazeri, Ahmad Shaabani, Behrouz Notash   +3 more
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N-Halosuccinimide enables cascade oxidative trifluorination and halogenative cyclization of tryptamine-derived isocyanides [PDF]

Nature Communications
Both the pyrroloindoline core and N–CF3 moiety hold significant importance in medicinal chemistry. However, to date, no instances of constructing N–CF3-containing pyrroloindolines have been reported.
Jun-Yunzi Wu, Long-Ling Huang, Jia-Luo Fu, Jia-Yi Li, Shuang Lin, Shuang Yang, Zhi-Shu Huang, Honggen Wang, Qingjiang Li   +8 more
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A More Sustainable Isocyanide Synthesis from N-Substituted Formamides Using Phosphorus Oxychloride in the Presence of Triethylamine as Solvent

Molecules, 2022
A simple, green, and highly efficient protocol for the synthesis of isocyanides is described. The reaction involves dehydration of formamides with phosphorus oxychloride in the presence of triethylamine as solvent at 0 °C.
Sodeeq Aderotimi Salami, Xavier Siwe-Noundou, Rui Werner Maçedo Krause   +2 more
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Efficient Isocyanide-less Isocyanide-Based Multicomponent Reactions [PDF]

Organic Letters, 2015
Isocyanides are the "Jekyll and Hyde" of organic chemistry allowing for extremely interesting transformations that are not only extremely odorous but also noxious. Therefore, an isocyanide-less isocyanide-based multicomponent reaction (IMCR) has been developed, and this protocol is expected to replace many of the old procedures in the future not only ...
Neochoritis, Constantinos G.; Stotani, Silvia; Mishra, Bhupendra; Domling, Alexander   +4 more
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2‐Nitrobenzyl Isocyanide as a Universal Convertible Isocyanide [PDF]

Asian Journal of Organic Chemistry, 2017
Abstract2‐Nitrobenzyl isocyanide is reported as a universal convertible isocyanide with extensive applicability in both Ugi four‐component reaction (Ugi‐4CR) and Ugi‐tetrazole reaction. The cleavage of this isocyanide from 17 examples in both acidic and basic conditions is presented.
Chandgude, Ajay L.; Li, Jingyao; Domling, Alexander   +3 more
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The isocyanide SN2 reaction

Nature Communications, 2023
Abstract The S N 2 nucleophilic substitution reaction is a vital organic transformation used for drug and natural product synthesis. Nucleophiles like cyanide, oxygen, nitrogen, sulfur, or phosphorous replace halogens or sulfonyl esters, forming new bonds.
Patil, Pravin, Zheng, Qiang, Kurpiewska, Katarzyna, Dömling, Alexander   +3 more
openaire   +4 more sources

Synthesis of Chromeno[3,4-b]piperazines by an Enol-Ugi/Reduction/Cyclization Sequence

Molecules, 2021
Keto piperazines and aminocoumarins are privileged building blocks for the construction of geometrically constrained peptides and therefore valuable structures in drug discovery.
Ana Bornadiego, Ana G. Neo, Carlos F. Marcos   +2 more
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Ugi Reaction on α-Phosphorated Ketimines for the Synthesis of Tetrasubstituted α-Aminophosphonates and Their Applications as Antiproliferative Agents

Molecules, 2021
An Ugi three-component reaction using preformed α-phosphorated N-tosyl ketimines with different isocyanides in the presence of a carboxylic acid affords tetrasubstituted α-aminophosphonates.
Adrián López-Francés, Xabier del Corte, Edorta Martínez de Marigorta, Francisco Palacios, Javier Vicario   +4 more
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Using highly substituted isocyanides in the synthesis ofiminothiophenes fused to quinolines [PDF]

شیمی کاربردی روز, 2018
In this manuscript the reaction of 2-mercaptoquinoline-3-carbaldehydes and 1,1,3,3-tetramethyl butylisocyanide as highly substituted isocyanide in the reflux of ethanol without catalyst is described.
Morteza Shiri, shima fazelzadeh, Zeinab Faghihi, Behrouz Notash   +3 more
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