Results 11 to 20 of about 5,434 (218)
Investigating the bioorthogonality of isocyanides.
Chem Commun (Camb)Isocyanides have been explored as bioorthogonal triggers for uncaging reactions. However, our findings show they can covalently label proteins, indicating they may not be fully bioorthogonal in biological systems.
Nakao R +7 more
europepmc +7 more sources
Silver-catalyzed anionic [3 + 2] cycloaddition of benzyl isocyanides with polyfluoroalkylchromones and pyrones: direct synthesis of 2-arylpyrroles [PDF]
Beilstein Journal of Organic ChemistryA silver-catalyzed anionic [3 + 2] cycloaddition of benzyl isocyanides has been developed, providing direct one-pot access to 2-arylpyrroles – a privileged scaffold pervasive in medicinal chemistry and functional materials.
Ivan A. Kochnev, Alexey Yu. Barkov
doaj +2 more sources
Microwave-Intensified Hofmann Carbylamine Reaction Enabled by Span® 80: Rapid Access to Isocyanides in a Biphasic System [PDF]
MoleculesIsocyanides constitute a valuable class of organic compounds widely employed in multicomponent reactions (MCRs), heterocycle synthesis, and drug discovery.
Wender Alves Silva +2 more
doaj +2 more sources
Controlled living ring expansion polymerization for the precision synthesis of cyclic poly(aryl isocyanides) [PDF]
Nature CommunicationsCyclic polymers exhibit physical properties distinct from those of their linear polymer counterparts. Although cyclic polymer materials with advanced designs can be synthesized using methods that control their molecular weight, dispersity, and topology ...
Eiichi Kayahara +2 more
doaj +2 more sources
The Chemistry of Isocyanides, their MultiComponent Reactions and their Libraries
Molecules, 2003 The first century of isocyanide chemistry, which was then still a rather empty part of Organic Chemistry, began in 1859. In 1958 isocyanides became generally available by dehydration the formylamines.
Alexander Domling, B Werner, I Ugi
exaly +3 more sources
Molecules, 2022 A simple, green, and highly efficient protocol for the synthesis of isocyanides is described. The reaction involves dehydration of formamides with phosphorus oxychloride in the presence of triethylamine as solvent at 0 °C.
Sodeeq Aderotimi Salami +2 more
doaj +1 more source
Visible light-driven dearomatization of tryptamine-derived isocyanides through aggregation-based charge transfer [PDF]
, 2023 Aggregation-based charge transfer has emerged as an attractive concept in organic chemistry. In this work, we have demonstrated the ability of tryptamine-derived isocyanides to form aggregates, which enable a single electron transfer step to generate ...
Minghui , Wu +7 more
core +2 more sources
Medicinal Chemistry of Isocyanides [PDF]
Chemical Reviews, 2021 In eons of evolution, isocyanides carved out a niche in the ecological systems probably thanks to their metal coordinating properties. In 1859 the first isocyanide was synthesized by humans and in 1950 the first natural isocyanide was discovered. Now, at the beginning of XXI century, hundreds of isocyanides have been isolated both in prokaryotes and ...
Alberto Massarotti +4 more
openaire +4 more sources
Nature Communications, 2023 Abstract The S N 2 nucleophilic substitution reaction is a vital organic transformation used for drug and natural product synthesis. Nucleophiles like cyanide, oxygen, nitrogen, sulfur, or phosphorous replace halogens or sulfonyl esters, forming new bonds.
Pravin Patil +3 more
openaire +4 more sources
2‐Nitrobenzyl Isocyanide as a Universal Convertible Isocyanide [PDF]
Asian Journal of Organic Chemistry, 2017 Abstract2‐Nitrobenzyl isocyanide is reported as a universal convertible isocyanide with extensive applicability in both Ugi four‐component reaction (Ugi‐4CR) and Ugi‐tetrazole reaction. The cleavage of this isocyanide from 17 examples in both acidic and basic conditions is presented.
Chandgude +3 more
openaire +3 more sources