Results 11 to 20 of about 1,650 (181)

Synthesis of Chromeno[3,4-b]piperazines by an Enol-Ugi/Reduction/Cyclization Sequence

Molecules, 2021
Keto piperazines and aminocoumarins are privileged building blocks for the construction of geometrically constrained peptides and therefore valuable structures in drug discovery.
Ana Bornadiego, Ana G. Neo, Carlos F. Marcos   +2 more
doaj   +1 more source

Ugi Reaction on α-Phosphorated Ketimines for the Synthesis of Tetrasubstituted α-Aminophosphonates and Their Applications as Antiproliferative Agents

Molecules, 2021
An Ugi three-component reaction using preformed α-phosphorated N-tosyl ketimines with different isocyanides in the presence of a carboxylic acid affords tetrasubstituted α-aminophosphonates.
Adrián López-Francés, Xabier del Corte, Edorta Martínez de Marigorta, Francisco Palacios, Javier Vicario   +4 more
doaj   +1 more source

Using highly substituted isocyanides in the synthesis ofiminothiophenes fused to quinolines [PDF]

شیمی کاربردی روز, 2018
In this manuscript the reaction of 2-mercaptoquinoline-3-carbaldehydes and 1,1,3,3-tetramethyl butylisocyanide as highly substituted isocyanide in the reflux of ethanol without catalyst is described.
Morteza Shiri, shima fazelzadeh, Zeinab Faghihi, Behrouz Notash   +3 more
doaj   +1 more source

Synthesis of Depsipeptides via Isocyanide-Based Consecutive Bargellini–Passerini Multicomponent Reactions

SynOpen, 2021
An efficient and straightforward approach has been established for the preparation of a new class of depsipeptide structures via isocyanide-based consecutive Bargellini–Passerini multicomponent reactions.
Hassan Farhid, Mohammad Mahdi Rostami, Ahmad Shaabani, Behrouz Notash   +3 more
doaj   +1 more source

Multicomponent Reactions of Isocyanides for the Preparation of Low Molecular Weight Gelators: Preliminary Studies

Chemistry Proceedings, 2021
Low molecular weight gelators, LMWGs, are small molecules that can self-associate in organic solvents or in water to form fibrous supramolecular architectures and three-dimensional networks that present important applications in several fields.
José L. Ramiro, Carlos F. Marcos, Ana G. Neo   +2 more
doaj   +1 more source

Three-Component Reaction of 3-Arylidene-3H-Indolium Salts, Isocyanides, and Alcohols

Frontiers in Chemistry, 2019
A novel isocyanide-based multicomponent synthesis of alkyl aryl(indol-3-yl)acetimidates has been established. Starting from aryl(indol-3-yl)methylium tetrafluoroborates, aromatic isocyanides and alcohols, the imidates were obtained in moderate to very ...
Nikita E. Golantsov, Hung M. Nguyen, Alexandra S. Golubenkova, Alexey V. Varlamov, Erik V. Van der Eycken, Erik V. Van der Eycken, Leonid G. Voskressensky   +6 more
doaj   +1 more source

Semisynthesis of 6β-Acetoxyvouacapane Derivatives via the Ugi-Azide Multicomponent Reaction

Chemistry Proceedings, 2022
A semisynthesis of 6β-acetoxyvouacapane-1,5-disusbtituted tetrazoles derivatives from the leaves of Caesalpinia platyloba by using the Ugi-azide multicomponent reaction as a key step reaction is described. To our knowledge, this is the first report where
Gabriela Servín-García, Luis Chacón-García, Joaquín González-Marrero, Mariana Macías-Alonso, Mario A. Gómez-Hurtado, Gabriela Rodríguez-García, Rosa E. del Río, Carlos J. Cortés-García   +7 more
doaj   +1 more source

Pyrrolidinodiones in Enol-Ugi, Enol-Passerini, and Anomalous Enol-Passerini Condensations

Proceedings, 2019
In continuation of our recent research on the development of novel multicomponent reactions with isocyanides, we have used, for the first time, enols as the acid components in Ugi- and Passerini-type reactions. Thus, electron-poor pyrrolidinodiones react
Ana G. Neo, Carlos F. Marcos
doaj   +1 more source

Cyclization of Activated Methylene Isocyanides with Methyl N(N),N′-Di(tri)substituted Carbamimidothioate: A Novel Entry for the Synthesis of N,1-Aryl-4-tosyl/ethoxycarbonyl-1H-imidazol-5-amines

SynOpen, 2019
Base-induced cyclization of active methylene isocyanides with carbamimidothioates for the synthesis of N,1-aryl-4-tosyl/ethylcarboxy-1H-imidazol-5-amines is reported.
Dukanya Dukanya, Toreshettahally R. Swaroop, Shobith Rangappa, Kanchugarakoppal S. Rangappa, Basappa Basappa   +4 more
doaj   +1 more source

Recent Advances in Palladium-Catalyzed Isocyanide Insertions

Molecules, 2020
Isocyanides have long been known as versatile chemical reagents in organic synthesis. Their ambivalent nature also allows them to function as a CO-substitute in palladium-catalyzed cross couplings.
Jurriën W. Collet, Thomas R. Roose, Bram Weijers, Bert U. W. Maes, Eelco Ruijter, Romano V. A. Orru   +5 more
doaj   +1 more source