Results 31 to 40 of about 5,182 (207)

Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines

open access: yesMolecules, 2019
A novel one-pot multicomponent reaction to synthesize substituted imidazopyrazines is described. In brief, 1H-(imidazol-5-yl)-N-substituted methanamines react with aldehydes and isocyanides in methanol at room temperature to give imidazopyrazine ...
Ubaldina Galli   +7 more
doaj   +1 more source

Three-Component Reactions of 3-Arylidene-3H-Indolium Salts, Isocyanides and Amines

open access: yesMolecules, 2021
A multicomponent reaction of isocyanides with aryl(indol-3-yl)methylium salts and amines has been found. A series of aryl(indol-3-yl)acetimidamides was obtained in up to 96% yields.
Hung M. Nguyen   +4 more
doaj   +1 more source

A novel three-component reaction between isocyanides, alcohols or thiols and elemental sulfur: a mild, catalyst-free approach towards O-thiocarbamates and dithiocarbamates

open access: yesBeilstein Journal of Organic Chemistry, 2019
A new multicomponent reaction has been developed between isocyanides, sulfur and alcohols or thiols under mild reaction conditions to afford O-thiocarbamates and dithiocarbamates in moderate to good yields.
András György Németh   +2 more
doaj   +1 more source

On the reaction of diphenylketene with isocyanides

open access: yesOrganic & Biomolecular Chemistry, 2005
The products obtained from the reaction of diphenylketene with a variety of isocyanides are shown to depend heavily on the concentration of diphenylketene; a high concentration results in the precedented dioxolane derivatives, at much lower concentrations the reactions follow an alternative course and polycyclic beta-lactams are generated by a cascade ...
Robertson, J, Bell, S, Krivokapic, A
openaire   +3 more sources

‐Dibromoalkenes and Isocyanides

open access: yes, 2018
An alternative method related to the formation of 3(hetero)arylpropynamides using palladium/Cs2CO3, the regiochemically-controlled coupling of isocyanides with 1,1dibromo-1-alkenes is ...
Morteza Shiri, Parvin Salehi
core   +1 more source

Structure and Reactivity of Glycosyl Isocyanides

open access: yesEuropean Journal of Organic Chemistry, 2018
3D structural information was obtained from mono‐, di‐ and trisaccharide formamide and isocyanide derivatives by analysis of their X‐ray crystal structure and NMR spectroscopy. The isocyanide anomeric effect was observed. Data mining of the Cambridge Structural Database (CSD) was performed and statistically confirmed our findings.
Constantinos G. Neochoritis   +6 more
openaire   +5 more sources

Leuckart-Wallach Approach to Sugar Isocyanides and Its IMCRs [PDF]

open access: yes, 2015
We utilize our recently introduced Leuckart-Wallach approach to synthesize anomeric sugar isocyanides in good overall yields and two steps. Moreover, we show the general usage of these isocyanides in isocyanide-based multicomponent reactions (IMCRs) to ...
Neochoritis, Dinos   +2 more
core   +2 more sources

Synthese und aktivitätsbasierte Proteinprofilierung identifizieren die Aldo‐Keto‐Reduktase 1C3 als Zielprotein der Myxoglucamide

open access: yesAngewandte Chemie, EarlyView.
Myxoglucamid A – ein neuartiges, aus Myxobakterien isoliertes Glykolipopeptid – wurde erstmals totalsynthetisch hergestellt. Mittels aktivitätsbasierter Proteinprofilierung (ABPP) wurde die Aldo‐Keto‐Reduktase 1C3 (AKR1C3) als primäres Zielprotein in menschlichen Zellen identifiziert.
Thomas Siemon   +9 more
wiley   +1 more source

Metabolic Fate of the Isocyanide Moiety: Are Isocyanides Pharmacophore Groups Neglected by Medicinal Chemists?

open access: yes, 2020
Despite the isolation of hundreds of bioactive isocyanides from terrestrial fungi and bacteria as well as marine organisms, the isocyanide functionality has so far received little attention from a medicinal chemistry standpoint. The widespread tenet that
Purghè, Beatrice   +4 more
core   +2 more sources

HETEROCYCLES FROM BIARYL ISOCYANIDES: PHENYLNAPHTHYL AND NAPHTHYLPHENYL SYSTEMS.

open access: yes, 1977
HETEROCYCLES FROM BIARYL ISOCYANIDES: PHENYLNAPHTHYL AND NAPHTHYLPHENYL ...
JAYANTIBHAI R. PATEL (7986260)
core   +6 more sources

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