Results 51 to 60 of about 5,434 (218)
Isocyanides inhibit [Fe]-hydrogenase with very high affinity
, 2010 [Fe]-Hydrogenase catalyzes the reversible activation of H2. CO and CN− inhibit this enzyme with low affinity (Ki≅0.1mM) by binding to the iron site of the bound iron-guanyrylpyridinol cofactor.
Kenichi Ataka +3 more
core +1 more source
Molecules, 2021 A facile and efficient one-pot three-component reaction method for the synthesis of thiazine-dicarboxylates is reported. Reaction of an isocyanide and dialkyl acetylenedicarboxylate with 2-amino-4H-1,3-thiazin-4-one derivatives containing both an acidic ...
Reagan L. Mohlala +4 more
doaj +1 more source
Advanced ScienceIncorporation of CO into substrates to construct high‐value carbonyl compounds is an intensive industrial carbonylation procedure, however, high toxicity and wide explosion limits (12.5–74.0 vol% in air) of CO limit its application in industrial ...
Jian Zhao +6 more
doaj +1 more source
Synthesis of N-7-Substituted Purines from Imidazole Precursors
Molecules, 1999 Synthesis of purines and purine mono-1-oxides from the respective 5-substituted 4-nitroimidazole derivatives is described. The commercially available 4-nitroimidazole, in a few simple steps (including Vicarious Nucleophilic Substitution of Hydrogen), was
Stanislaw Ostrowski
doaj +1 more source
HETEROCYCLES FROM BIARYL AZIDES AND BIARYL ISOCYANIDES: CERTAIN PYRIDYLPHENYL SYSTEMS.
, 1977 HETEROCYCLES FROM BIARYL AZIDES AND BIARYL ISOCYANIDES: CERTAIN PYRIDYLPHENYL ...
CHING-CHENG. LAI (7979033)
core +3 more sources
Angewandte Chemie International Edition, EarlyView.Click chemistry has evolved from making covalent connections to also breaking bonds. Here, a cascade assembly is reported that combines these maneuvers to build multifunctional biomolecular scaffolds in a modular one‐pot reaction. The unifying azide release‐tetrazine hub clicks with a trans‐cyclooctene tag, rapidly liberates N,N‐dimethylaniline to ...
Markus Staudt +9 more
wiley +1 more source
One‐Pot Synthesis of a Small Synthetic Ligand for Antibody Purification
Biotechnology and Bioengineering, EarlyView.One‐pot liquid‐phase synthesis of the synthetic ligand B1Al2A2 enables controllable ligand density and efficient capture of IgG and IgY with high recovery and purity, streamlining small‐ligand affinity purification workflows. ABSTRACT The development of synthetic affinity ligands offers a cost‐effective alternative to traditional biological ligands ...
Carolina Mota Natal +8 more
wiley +1 more source
‐Dibromoalkenes and Isocyanides
, 2018 An alternative method related to the formation of 3(hetero)arylpropynamides using palladium/Cs2CO3, the regiochemically-controlled coupling of isocyanides with 1,1dibromo-1-alkenes is ...
Morteza Shiri, Parvin Salehi
core +1 more source
A Conserved Isoleucine Gates the Diffusion of CO and O2 to the Active Site of NiFe CO‐Dehydrogenase
Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.A combination of protein film electrochemistry and site‐directed mutagenesis shows that isoleucine 563 (numbering of Thermococcus sp. AM4) gates the arrival of both CO and O2 to the active site of the nickel‐iron CO dehydrogenases. Mutations at this position increase the resistance to O2 at the cost of a slower reaction with CO.
Laura Opdam +7 more
wiley +2 more sources
Accelerating green heterocyclic synthesis: Convergence of AI, automation, and sustainable chemistry
Bulletin of the Korean Chemical Society, EarlyView.Green heterocyclic synthesis and data‐driven tools such as AI, high‐throughput experimentation, continuous flow, and self‐driving laboratories have developed largely in parallel. This review connects them and asks how green metrics such as E‐factor and PMI might serve as explicit optimization targets rather than post‐hoc measures, toward sustainable ...
Noor Aisyah Ahmad Shah +8 more
wiley +1 more source