Results 71 to 80 of about 5,434 (218)

C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins

Chemistry – A European Journal, EarlyView.
C‐terminal functionalization offers powerful routes to peptide and protein diversification, yet epimerization, hydrolysis, and selectivity remain key challenges. This Review surveys enzymatic, decarboxylative, and condensation strategies, highlighting advances toward chemo‐ and regioselective, protecting‐group‐free, atom‐efficient methods applicable to
Jay Hanssens, Mark Lambers, Romano V. A. Orru, Jordy M. Saya   +3 more
wiley   +1 more source

Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics

Beilstein Journal of Organic Chemistry, 2014
In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has received much attention. This because they have shown in many cases enhanced pharmacological properties over their natural peptide analogues.
Gijs Koopmanschap, Eelco Ruijter, Romano V.A. Orru   +2 more
doaj   +1 more source

Phosphoranaloga von Aminosäuren und Peptiden: Kettenverlängerung von Carbonylverbindungen

CHIMIA, 1982
Synthesis of carbonyl compounds 5 involving the Wittig-Horner reaction of diethyl-1-isocyanoalkylphosphonate 1 with carbonyl compounds 2 and subsequent hydrolysis of the vinyl isocyanides 3 formed is reported.
Janusz Rachoń
doaj   +1 more source

Organic photonic synaptic transistors for bionic vision: From spectral engineering to flexible intelligent perception

FlexMat, EarlyView.
Different wavelength photonic synapses are used for biomimetic visual applications. Abstract Bionic intelligent visual perception systems have significant application prospects in fields such as autonomous driving and robotics, medical imaging and auxiliary diagnosis, security and monitoring.
Longlong Jiang, Shan Wu, Silu Feng, Heyi Huang, Wangyu Wu, Hong Han, Yao Ni   +6 more
wiley   +1 more source

Diastereoselective Ugi reaction of chiral 1,3-aminoalcohols derived from an organocatalytic Mannich reaction

Beilstein Journal of Organic Chemistry, 2016
Enantiomerically pure β-aminoalcohols, produced through an organocatalytic Mannich reaction, were subjected to an Ugi multicomponent reaction under classical or Lewis acid-promoted conditions with diastereoselectivities ranging from moderate to good ...
Samantha Caputo, Andrea Basso, Lisa Moni, Renata Riva, Valeria Rocca, Luca Banfi   +5 more
doaj   +1 more source

Metal-Mediated Addition of N-Nucleophiles to Isocyanides: Mechanistic Aspects

Molecules, 2017
Despite the long history of the investigation of nucleophilic addition to metal-bound isocyanides, some important aspects of the reaction mechanism remain unclear even for the simplest systems.
Maxim L. Kuznetsov, Vadim Yu. Kukushkin
doaj   +1 more source

Protic N‐Heterocyclic Carbene Ligands in Ruthenium‐Catalyzed Transfer Hydrogenation

Helvetica Chimica Acta, EarlyView.
The activity of ruthenium transfer hydrogenation catalysts is strongly influenced by the number of protic units in the N‐heterocyclic carbene ligand. Doubly protic NH, NH ligands induce slower activity than mono‐protic NH, NMe ligands, while NMe, NMe ligands display the highest activity, suggesting metal‐ligand cooperativity is not beneficial for these
Gianluca Righetti, Georgyi Koidan, Sergiy L. Filimonchuk, Svitlana Shishkina, Aleksandr Kostyuk, Martin Albrecht   +5 more
wiley   +1 more source

Multicomponent Reactions Upon the Known Drug Trimethoprim as a Source of Novel Antimicrobial Agents

Frontiers in Chemistry, 2019
Novel antibiotic compounds have been prepared through a selective multicomponent reaction upon the known drug Trimethoprim. The Groebke-Blackburn-Bienaymé reaction involving this α-aminoazine, with a range of aldehydes and isocyanides afforded the ...
Marina Pedrola, Marta Jorba, Marta Jorba, Eda Jardas, Ferran Jardi, Ouldouz Ghashghaei, Miguel Viñas, Miguel Viñas, Rodolfo Lavilla   +8 more
doaj   +1 more source

Controlling Linear and Non‐Linear Mechanics in Multicomponent Hydrogels Through Programmable Supramolecular and Covalent Interactions

Journal of Polymer Science, EarlyView.
Fully synthetic, multi‐component hydrogels are engineered that possess tunable (non)‐linear mechanics by programmable supramolecular and covalent interactions. By changing the type of inter‐network interaction, the linear and non‐linear mechanics of the macroscopic hydrogel were programmed.
Martin G. T. A. Rutten, Laura Rijns, Jingyi Huang, Ruth Cardinaels, Paul H. J. Kouwer, Patricia Y. W. Dankers   +5 more
wiley   +1 more source

2D Rhodium‐Isocyanide Frameworks

Advanced Materials
Abstract 2D metal‐organic frameworks (2D MOFs) are emerging organic van der Waals materials with great potential in various applications owing to their structural diversity, and tunable optoelectronic properties.
Senhe Huang, Pu Yan, Zhiya Han, Hongyu Wu, Youcheng Wang, Jichao Zhang, Lei Yuan, Shuai Fu, Guanzhao Wen, Jinhui Zhu, Mischa Bonn, Hai I. Wang, Kecheng Cao, Xiaodong Zhuang   +13 more
openaire   +3 more sources