Results 91 to 100 of about 5,182 (207)

Metal-Mediated Addition of N-Nucleophiles to Isocyanides: Mechanistic Aspects

Molecules, 2017
Despite the long history of the investigation of nucleophilic addition to metal-bound isocyanides, some important aspects of the reaction mechanism remain unclear even for the simplest systems.
Maxim L. Kuznetsov, Vadim Yu. Kukushkin
doaj   +1 more source

Multicomponent Reactions Upon the Known Drug Trimethoprim as a Source of Novel Antimicrobial Agents

Frontiers in Chemistry, 2019
Novel antibiotic compounds have been prepared through a selective multicomponent reaction upon the known drug Trimethoprim. The Groebke-Blackburn-Bienaymé reaction involving this α-aminoazine, with a range of aldehydes and isocyanides afforded the ...
Marina Pedrola, Marta Jorba, Marta Jorba, Eda Jardas, Ferran Jardi, Ouldouz Ghashghaei, Miguel Viñas, Miguel Viñas, Rodolfo Lavilla   +8 more
doaj   +1 more source

Palladium-Catalyzed Synthesis of α‑Diimines from Triarylbismuthines and Isocyanides

, 2016
In this study, we report a highly selective coupling reaction between triarylbismuthines and isocyanides using palladium diacetate as the catalyst, affording α-diimines, with the formation of three C–C bonds. Among several aryl sources (Ar–YLn: Y = B, Sn,
Yohsuke Kobiki (1667290), Shin-ichi Kawaguchi (1667293), Akiya Ogawa (1447147)   +2 more
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Crystal structure and Hirshfeld surface analysis of chlorido(2,6-dimethylphenyl isocyanide)[N′-(2,6-dimethylphenyl)-N-(pyridin-2-yl)carbamimidoyl]platinum(II)

Acta Crystallographica Section E: Crystallographic Communications
In the title compound, [Pt(C14H14N3)Cl(C9H9N)], the platinum atom has a square-planar geometry. In the crystal, dimers with R22(8) motifs are formed by pairs of N—H...N hydrogen bonds.
Olga V. Repina, Elena Yu. Nevskaya, Ilya S. Kritchenkov, Victor N. Khrustalev, Alexander S. Novikov, Alexander G. Tskhovrebov, Namiq Q. Shikhaliyev, Aytan A. Niyazova, Mehmet Akkurt, Ajaya Bhattarai   +9 more
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Thiol mediated radical cyclisations of isocyanides : synthesis of N-heterocycles

, 2003
This thesis is concerned with the synthesis and radical cyclisations of alkenyl and alkynl isocyanides with thiols. Special interest is given to developing a fast and efficient synthetic route to functionalised N-heterocycles and polycylic systems ...
Lamberto, Massimiliano
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N-Halosuccinimide enables cascade oxidative trifluorination and halogenative cyclization of tryptamine-derived isocyanides

Nature Communications
Both the pyrroloindoline core and N–CF3 moiety hold significant importance in medicinal chemistry. However, to date, no instances of constructing N–CF3-containing pyrroloindolines have been reported.
Jun-Yunzi Wu, Long-Ling Huang, Jia-Luo Fu, Jia-Yi Li, Shuang Lin, Shuang Yang, Zhi-Shu Huang, Honggen Wang, Qingjiang Li   +8 more
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Pseudo-Five-Component Condensation for the Diversity-Oriented Synthesis of Novel Indoles and Quinolines Containing Pseudo-Peptides (Tricarboxamides) [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2018
A novel series of indole and quinoline tricarboxamides were synthesized using simple and efficient one-pot pseudo-five-component reactions of 2-formylindole or 2-chloro-3-formyl quinolines, isocyanides, amines, and Meldrum’s acid as a CH-acid in CH2Cl2 ...
Morteza Shiri, Majid Mohamed Heravi, Vahideh Zadsirjan, Atefeh Nejatinezhad-Arani, Suhas Ashok Shintre, Neil Anthony Koorbanally   +5 more
doaj  

Development and mechanistic studies of calcium–BINOL phosphate-catalyzed hydrocyanation of hydrazones

Beilstein Journal of Organic Chemistry
Asymmetric hydrocyanation of hydrazones, catalyzed by a calcium–BINOL phosphate complex, has been studied for the first time both experimentally and computationally with DFT methods.
Carola Tortora, Christian A. Fischer, Sascha Kohlbauer, Alexandru Zamfir, Gerd M. Ballmann, Jürgen Pahl, Sjoerd Harder, Svetlana B. Tsogoeva   +7 more
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Pyrrolidinone and Piperidinone Isocyanides from Isocyano Esters

, 2014
International audienceThe alkylation of isocyano esters with 1,2- and 1,3-dibromoalkanes affords bromo isocyanides. Under treatment with various amines the latter form new isocyano-substituted lactams, which can be further used in Passerini or Ugi ...
Legras, Laetitia, Ait Sidhoum, Naïm, dos Santos, Aurélie, El Kaim, Laurent   +3 more
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Palladium-Catalyzed Multicomponent Reaction (MCR) of Propargylic Carbonates with Isocyanides

, 2016
A palladium-catalyzed multicomponent reaction (MCR) of propargylic carbonates with isocyanides is reported. Remarkably, the orderly insertion of isocyanides affords two types of valuable N-heterocyclic products (Z)-6-imino-4,6-dihydro-1H-furo­[3,4-b ...
Yanwei Ren (1392910), Yinglan Gao (1554796), Weigao Hu (1393459), Jianwen Peng (1554799), Wanqing Wu (796508), Miao Hu (380096), Yang Gao (18005), Huanfeng Jiang (1392913)   +7 more
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