Results 91 to 100 of about 5,434 (218)
, 2019 Using tetraaryllead compounds (PbAr4) as arylating reagents, isocyanides undergo selective diarylation in the presence of palladium catalysts such as Pd(OAc)2 or Pd(PPh3)4 to afford imines and/or α-diimines based on the isocyanide employed.
Hitomi Matsubara (7340288) +7 more
core +1 more source
FeIII‐Mediated Synthesis of Azaspirodienones via Ipso‐Radical Cyclization of Ugi–4CR Adducts
European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.An efficient two‐step protocol for the synthesis of azaspirodienones via Fe‐mediated ipso‐radical cyclization of Ugi adducts has been developed. This methodology provides rapid access to these privileged spirocyclic architectures under mild conditions, offering a practical and versatile approach to generating structurally complex molecules with ...
Silvia J. Becerra–Anaya +2 more
wiley +1 more source
, 2016 Isocyanides have emerged as valuable C1 building blocks in palladium catalysis. Their potential has, however, mainly been exploited for the synthesis of amidines and amidine-containing heterocycles. To illustrate the broader applicability of isocyanides,
Tjøstil Vlaar (1863328) +3 more
core +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 38, 13 October 2026.A practical strategy for synthesizing β‐ and γ‐carbolinones from indole‐based Ugi 4‐CR adducts through an intramolecular radical cyclization using Fe(III)–H species is presented. This approach enables the efficient synthesis of spiro‐carbolinones under mild reaction conditions and demonstrates the effectiveness of secondary radicals in both cyclization
María F. Olvera‐Granados +1 more
wiley +1 more source
Metal-Template-Controlled Stabilization of β‑Functionalized Isocyanides
, 2016 Reaction of 2-azidoethyl isocyanide 1, 2-azidophenyl isocyanide 2, or 2-nitrophenyl isocyanide 3 with complexes [Mo(CO)3(dppe)(py)] [4] or [W(CO)3(dppe)(NCCH3)] [5] yields the isocyanide complexes [Mo(CO)3(dppe)(CNR)] ([6]: CNR = 1; [12]: CNR =
Jutta Kösters (1607449) +5 more
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Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.Myxoglucamid A – ein neuartiges, aus Myxobakterien isoliertes Glykolipopeptid – wurde erstmals totalsynthetisch hergestellt. Mittels aktivitätsbasierter Proteinprofilierung (ABPP) wurde die Aldo‐Keto‐Reduktase 1C3 (AKR1C3) als primäres Zielprotein in menschlichen Zellen identifiziert.
Thomas Siemon +9 more
wiley +1 more source
Angewandte Chemie International Edition, Volume 65, Issue 41, 5 October 2026.Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon +9 more
wiley +1 more source
, 2016 Upon photoirradiation of o-alkynylaryl isocyanides in the presence of iodine, the intramolecular cyclization of o-alkynylaryl isocyanides proceeds to afford the corresponding 2,4-diiodoquinolines in good yields.
Takenori Mitamura (2198395) +1 more
core +3 more sources
Passerini Reactions on Biocatalytically Derived Chiral Azetidines
Molecules, 2016 The purpose of this study was to explore a series of Passerini reactions on a biocatalytically derived enantiopure azetidine-2-carboxyaldehyde in order to obtain, in a diastereoselective manner, polyfunctionalised derivatives having the potential to be ...
Lisa Moni +6 more
doaj +1 more source
, 2018 An efficient, copper-catalyzed [3+1+1] cycloaddition reaction was developed for the expedient synthesis of pharmacologically interesting polysubstituted pyrroles from easily available nitrones and α-acidic isocyanides.
Jiaojiao Xu (813939) +4 more
core +1 more source