Results 21 to 30 of about 5,434 (218)

Efficient Isocyanide-less Isocyanide-Based Multicomponent Reactions [PDF]

Organic Letters, 2015
Isocyanides are the "Jekyll and Hyde" of organic chemistry allowing for extremely interesting transformations that are not only extremely odorous but also noxious. Therefore, an isocyanide-less isocyanide-based multicomponent reaction (IMCR) has been developed, and this protocol is expected to replace many of the old procedures in the future not only ...
Neochoritis, Constantinos G.; Stotani, Silvia; Mishra, Bhupendra; Domling, Alexander   +4 more
openaire   +3 more sources

Physicochemical, biological and application properties of isocyanides, Part 1., Origins, derivation and chemical reactions [PDF]

, 2023
Isocyanides are the most unusual and unique group in organic chemistry. They possess an unusual valence structure and reactivity. Isocyanides are the only class of stable organic compounds with a formal divalent carbon, which allows them to be the ...
Pobłocki, Kacper, Jacewicz, Dagmara, Pawlak, Marta, Drzeżdżon, Joanna   +3 more
core   +1 more source

Synthesis of Chromeno[3,4-b]piperazines by an Enol-Ugi/Reduction/Cyclization Sequence

Molecules, 2021
Keto piperazines and aminocoumarins are privileged building blocks for the construction of geometrically constrained peptides and therefore valuable structures in drug discovery.
Ana Bornadiego, Ana G. Neo, Carlos F. Marcos   +2 more
doaj   +1 more source

Ugi Reaction on α-Phosphorated Ketimines for the Synthesis of Tetrasubstituted α-Aminophosphonates and Their Applications as Antiproliferative Agents

Molecules, 2021
An Ugi three-component reaction using preformed α-phosphorated N-tosyl ketimines with different isocyanides in the presence of a carboxylic acid affords tetrasubstituted α-aminophosphonates.
Adrián López-Francés, Xabier del Corte, Edorta Martínez de Marigorta, Francisco Palacios, Javier Vicario   +4 more
doaj   +1 more source

Using highly substituted isocyanides in the synthesis ofiminothiophenes fused to quinolines [PDF]

شیمی کاربردی روز, 2018
In this manuscript the reaction of 2-mercaptoquinoline-3-carbaldehydes and 1,1,3,3-tetramethyl butylisocyanide as highly substituted isocyanide in the reflux of ethanol without catalyst is described.
Morteza Shiri, shima fazelzadeh, Zeinab Faghihi, Behrouz Notash   +3 more
doaj   +1 more source

Synthesis of Depsipeptides via Isocyanide-Based Consecutive Bargellini–Passerini Multicomponent Reactions

SynOpen, 2021
An efficient and straightforward approach has been established for the preparation of a new class of depsipeptide structures via isocyanide-based consecutive Bargellini–Passerini multicomponent reactions.
Hassan Farhid, Mohammad Mahdi Rostami, Ahmad Shaabani, Behrouz Notash   +3 more
doaj   +1 more source

Sulfonyl isocyanides RSO2NC [PDF]

, 2017
Flash vacuum pyrolysis (FVP) of 5-azido-1-aryltetrazoles results in triple N2 elimination and formation of aryl isocyanides RNC, which rearrange in part to aroylnitriles RCN under the reaction conditions.
Horst, Briehl, Curt, Wentrup
core   +1 more source

Amide-Stabilized Enols in the Enol-Ugi Reaction: A Five-Component Synthesis of Triamides

Chemistry Proceedings, 2021
In continuation with our research in the use of enols in multicomponent reactions with isocyanides (IMCR), for the first time we have used amide-stabilized enols as the acid component in enol-Ugi reactions.
Ana G. Neo, M. Teresa G. Castellano, José L. Ramiro, Carlos F. Marcos   +3 more
doaj   +1 more source

Three-Component Reaction of 3-Arylidene-3H-Indolium Salts, Isocyanides, and Alcohols

Frontiers in Chemistry, 2019
A novel isocyanide-based multicomponent synthesis of alkyl aryl(indol-3-yl)acetimidates has been established. Starting from aryl(indol-3-yl)methylium tetrafluoroborates, aromatic isocyanides and alcohols, the imidates were obtained in moderate to very ...
Nikita E. Golantsov, Hung M. Nguyen, Alexandra S. Golubenkova, Alexey V. Varlamov, Erik V. Van der Eycken, Erik V. Van der Eycken, Leonid G. Voskressensky   +6 more
doaj   +1 more source

Silver-Catalyzed Decarboxylative Acylation of Isocyanides Accesses to α-Ketoamides with Air as a Sole Oxidant

Molecules, 2023
α-Ketoamide moieties, as privileged units, may represent a valuable option to develop compounds with favorable biological activities, such as low toxicity, promising PK and drug-like properties.
Jia Xu, Xue Li, Xing-Yu Chen, Yu-Ting He, Jie Lei, Zhong-Zhu Chen, Zhi-Gang Xu   +6 more
doaj   +1 more source