Results 21 to 30 of about 8,383 (210)

Pyrrolidinodiones in Enol-Ugi, Enol-Passerini, and Anomalous Enol-Passerini Condensations

Proceedings, 2019
In continuation of our recent research on the development of novel multicomponent reactions with isocyanides, we have used, for the first time, enols as the acid components in Ugi- and Passerini-type reactions. Thus, electron-poor pyrrolidinodiones react
Ana G. Neo, Carlos F. Marcos
doaj   +1 more source

Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2-Aminophenyl Ketones and 2-Aminobenzamides with Amines [PDF]

, 2019
The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form quinazoline products.
Arachchige, Pandula T. Kirinde, Yi, Chae S.   +1 more
core   +3 more sources

Isocyanide 2.0

Green Chemistry, 2020
Isocyanides are important chemicals, with limited availability, thus reducing their general use. Our highly improved isocyanide synthesis performed on mole to μ-mole scale, individually or in a 96-well parallel fashion enables unprecedented exploration of novel chemistries.
Pravin Patil, Maryam Ahmadian-Moghaddam, Alexander Dömling   +2 more
openaire   +3 more sources

A Stepwise [4 + 3] Cycloaddition Reaction of the 1,3-Diphenyl-2-azaallyl Anion [PDF]

, 1993
The 1,3-diphenyl-2-azaallyl anion (1) undergoes [3 + 2] cycloaddition reactions with the s-cis-fixed 1,3-dienes 8-11. In contrast, 1,1,2,2,3,3-hexamethyl-4,5-bis(methylene)cyclopentane (7) reacts with 1 to give the [4 + 3] cycloadduct 13 and the linear 1,
Anh, Baran, Baran, Baran, Baran, Baran, Blomquist, Boche, Boche, Bower, Eidenschink, Fleming, Huisgen, Juday, Kauffmann, Kauffmann, Kaufmann, Mayr, Mayr, Mayr, Mayr, van Straten, Wilcox, Woodward   +23 more
core   +1 more source

Cyclization of Activated Methylene Isocyanides with Methyl N(N),N′-Di(tri)substituted Carbamimidothioate: A Novel Entry for the Synthesis of N,1-Aryl-4-tosyl/ethoxycarbonyl-1H-imidazol-5-amines

SynOpen, 2019
Base-induced cyclization of active methylene isocyanides with carbamimidothioates for the synthesis of N,1-aryl-4-tosyl/ethylcarboxy-1H-imidazol-5-amines is reported.
Dukanya Dukanya, Toreshettahally R. Swaroop, Shobith Rangappa, Kanchugarakoppal S. Rangappa, Basappa Basappa   +4 more
doaj   +1 more source

Recent Advances in Palladium-Catalyzed Isocyanide Insertions

Molecules, 2020
Isocyanides have long been known as versatile chemical reagents in organic synthesis. Their ambivalent nature also allows them to function as a CO-substitute in palladium-catalyzed cross couplings.
Jurriën W. Collet, Thomas R. Roose, Bram Weijers, Bert U. W. Maes, Eelco Ruijter, Romano V. A. Orru   +5 more
doaj   +1 more source

13C-Methyl isocyanide as an NMR probe for cytochrome P450 active site [PDF]

, 2009
The cytochromes P450 (CYPs) play a central role in many biologically important oxidation reactions, including the metabolism of drugs and other xenobiotic compounds.
Im, Sang-Choul, McCullough, Christopher R, Pullela, Phani Kumar, Sem, Daniel S., Waskell, Lucy   +4 more
core   +2 more sources

The Chemistry of Isocyanides, their MultiComponent Reactions and their Libraries

Molecules, 2003
The first century of isocyanide chemistry, which was then still a rather empty part of Organic Chemistry, began in 1859. In 1958 isocyanides became generally available by dehydration the formylamines.
A. Dömling, B. Werner, I. Ugi
doaj   +1 more source

Laboratory Characterization and Astrophysical Detection of Vibrationally Excited States of Vinyl Cyanide in Orion-KL [PDF]

, 2014
New laboratory data of CH$_2$CHCN (vinyl cyanide) in its ground and vibrationally excited states at the microwave to THz domain allow searching for these excited state transitions in the Orion-KL line survey.
Alonso, J. L., Bermúdez, C., Calcutt, H., Cernicharo, J., Daly, A. M., Drouin, B. J., Kisiel, Z., López, A., Marcelino, N., Medvedev, I. R., Neese, C. F., Pszczółkowski, L., Tercero, B., Viti, S.   +13 more
core   +2 more sources

Silver-Catalyzed Decarboxylative Acylation of Isocyanides Accesses to α-Ketoamides with Air as a Sole Oxidant

Molecules, 2023
α-Ketoamide moieties, as privileged units, may represent a valuable option to develop compounds with favorable biological activities, such as low toxicity, promising PK and drug-like properties.
Jia Xu, Xue Li, Xing-Yu Chen, Yu-Ting He, Jie Lei, Zhong-Zhu Chen, Zhi-Gang Xu   +6 more
doaj   +1 more source