Results 51 to 60 of about 1,583 (164)
Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics
Beilstein Journal of Organic Chemistry, 2014 In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has received much attention. This because they have shown in many cases enhanced pharmacological properties over their natural peptide analogues.
Gijs Koopmanschap +2 more
doaj +1 more source
Macromolecular Rapid Communications, EarlyView.We report here a new methodology to prepare functional poly(acetylene)s under aqueous conditions. This methodology is underpinned by poly(O‐propargyl‐N‐amino carbamate) (P1), a reactive poly(acetylene) carrying acyl hydrazines. Thus, P1 reacts with aldehydes to give functional poly(acetylene)s, including cationic, hydrophobic, and sugar‐loaded poly ...
Tom Leigh +8 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2016 Enantiomerically pure β-aminoalcohols, produced through an organocatalytic Mannich reaction, were subjected to an Ugi multicomponent reaction under classical or Lewis acid-promoted conditions with diastereoselectivities ranging from moderate to good ...
Samantha Caputo +5 more
doaj +1 more source
Draft genome of Neofabraea vagabunda, the agent of bull's eye rot
Annals of Applied Biology, EarlyView.Circular representation of the 12 major scaffolds from the draft genome of Neofabraea vagabunda showing gene density, density of repeated regions, GC content, and functional features (secrete and membrane proteins, proteases, and CAZymes) distribution.
Saveria Mosca +4 more
wiley +1 more source
Phosphoranaloga von Aminosäuren und Peptiden: Kettenverlängerung von Carbonylverbindungen
CHIMIA, 1982 Synthesis of carbonyl compounds 5 involving the Wittig-Horner reaction of diethyl-1-isocyanoalkylphosphonate 1 with carbonyl compounds 2 and subsequent hydrolysis of the vinyl isocyanides 3 formed is reported.
Janusz Rachoń
doaj +1 more source
Electrochemical Decarboxylative Hydroxylation for the Sustainable Synthesis of Bempedoic Acid
ChemElectroChem, Volume 13, Issue 6, 17 March 2026.A sustainable synthesis of bempedoic acid is achieved using electrochemical hydroxylative decarboxylation as the key step. Starting from Meldrum's acid, mild metal‐free alkylation, hydrolysis, and decarboxylation provide the key precursor, which is electrochemically converted to the alcohol intermediate and then hydrolyzed to the final product ...
Pietro Ronco +6 more
wiley +1 more source
Metal-Mediated Addition of N-Nucleophiles to Isocyanides: Mechanistic Aspects
Molecules, 2017 Despite the long history of the investigation of nucleophilic addition to metal-bound isocyanides, some important aspects of the reaction mechanism remain unclear even for the simplest systems.
Maxim L. Kuznetsov, Vadim Yu. Kukushkin
doaj +1 more source
Base Metal Catalyzed Isocyanide Insertions [PDF]
Angewandte Chemie, 2019 AbstractIsocyanides are diverse C1 building blocks considering their potential to react with nucleophiles, electrophiles, and radicals. Therefore, perhaps not surprisingly, isocyanides are highly valuable as inputs for multicomponent reactions (MCRs) and other one‐pot cascade processes.
Jurriën W. Collet +4 more
openaire +3 more sources
Multicomponent Reactions Upon the Known Drug Trimethoprim as a Source of Novel Antimicrobial Agents
Frontiers in Chemistry, 2019 Novel antibiotic compounds have been prepared through a selective multicomponent reaction upon the known drug Trimethoprim. The Groebke-Blackburn-Bienaymé reaction involving this α-aminoazine, with a range of aldehydes and isocyanides afforded the ...
Marina Pedrola +8 more
doaj +1 more source
, 2014 Citation: 'isocyanides' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.I03270 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source