Results 101 to 110 of about 12,264 (248)

Diatom-derived highly branched isoprenoids in lake waters and sediments

Diatom-derived highly branched isoprenoids (HBIs) are found extensively in marine sediments, but are observed in a limited number of lake sediments. To expand on this record, between 2022 and 2024, we collected lake surface sediment samples from 50 lakes
Diefendorf, Aaron F, Corcoran, Megan C, Lowell, Thomas V, Dietrich, Watts, Naake, Hans H   +4 more
core   +1 more source

Targeting of Staphyloxanthin and α‐Hemolysin by Natural Compound L‐Malic Acid Suppresses Staphylococcus aureus Virulence

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
L‐malic acid, a natural TCA cycle intermediate, attenuates the virulence of Staphylococcus aureus through dual metabolic and regulatory mechanisms. It redirects central carbon flux away from the mevalonate pathway and inhibits the key enzyme CrtO, suppressing staphyloxanthin biosynthesis and impairing bacterial resistance to oxidative stress ...
Li Shen, Bingjie Wang, Jinjin Yang, Xinru Yuan, Zhixuan Chen, Can Yang, Jiana Fu, Haojin Gao, Weihua Han, Junhong Shi, Fangyou Yu, Jingyi Yu   +11 more
wiley   +1 more source

Aβ inhibits SREBP-2 activation through Akt inhibition

Journal of Lipid Research, 2018
We previously demonstrated that oligomeric amyloid β42 (oAβ42) inhibits the mevalonate pathway impairing cholesterol synthesis and protein prenylation. Enzymes of the mevalonate pathway are regulated by the transcription factor SREBP-2.
Amany Mohamed, Anissa Viveiros, Kathleen Williams, Elena Posse de Chaves   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, Volume 600, Issue 11, Page 1621-1637, June 2026.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes

Advanced NanoBiomed Research, Volume 6, Issue 6, June 2026.
Archaeal lipid‐based liposomes, particularly those containing caldarchaeol (GDGT), were found to significantly prolong the circulation time of vancomycin in rats, matching the pharmacokinetic properties of PEGylated systems. These findings suggest archaeal lipids as promising non‐PEG excipients for parenteral applications to minimize drug clearance ...
Viktor Sedlmayr, Andreas D. Meid, Eric Mühlberg, Manuel Ben Böhmann, Julian Quehenberger, David Wurm, Mikko Gynther, Oliver Spadiut, Gert Fricker, Philipp Uhl   +9 more
wiley   +1 more source

δ‐Tocotrienol Inhibits Migration and Reduces Chemoresistance in Ovarian Cancer Stem‐Like Cells

eFood, Volume 7, Issue 3, June 2026.
δ‐Tocotrienol targets ovarian cancer stem cell populations and suppresses stem‐like traits, migration, and chemoresistance, with concomitant downregulation of Akt and NF‐κB signaling. ABSTRACT Ovarian cancer (OC) is the most lethal form of gynecologic malignancies, due to its intrinsic chemoresistance and ability to relapse.
Gaia Giannitti, Sara Marchesi, Riccardo Garavaglia, Ivan Preosto, Fabrizio Fontana   +4 more
wiley   +1 more source

Highly branched isoprenoids in lake photic zone water

Diatom-derived highly branched isoprenoids (HBIs) are found extensively in marine sediments, but are observed in a limited number of lake sediments. To expand on this record, between 2022 and 2024, we collected lake surface sediment samples from 50 lakes
Diefendorf, Aaron F, Corcoran, Megan C, Lowell, Thomas V, Dietrich, Watts, Naake, Hans H   +4 more
core   +1 more source

Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency.

, 2008
Mevalonate kinase deficiency (MKD) is a rare disorder characterized by recurrent inflammatory episodes and, in most severe cases, by psychomotor delay.
MARCUZZI, ANNALISA, VENTURA, ALESSANDRO, Luigina De Leo, Annalisa Marcuzzi, DE LEO, LUIGINA, Alessandra Pontillo, PONTILLO, Alessandra, Alberto Tommasini, Alessandro Ventura, TOMMASINI, ALBERTO, NOT, TARCISIO, Giuliana Decorti, DECORTI, GIULIANA, Tarcisio Not   +13 more
core   +1 more source

Pharmacological and Phytochemical Insights Into Ficus benghalensis (Indian Banyan): Anti‐Inflammatory, Antioxidant, and Anticancer Potentials

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
The aim of this review is to critically evaluate the therapeutic potential of Ficus benghalensis L. by integrating ethnomedicinal knowledge with contemporary scientific evidence. The objectives are to summarize its phytochemical profile, analyze antioxidant, antimicrobial, antidiabetic, anti‐inflammatory, and anticancer activities, elucidate underlying
Zainab Ali, Farhang Hameed Awlqadr, Uswa Ali, Iffat Ullah, Muhammad Tayyab Arshad, Abdul Rauf, Humaira Parveen, Sayeed Mukhtar, Uzma Faridi, Md. Sakhawot Hossain   +9 more
wiley   +1 more source

Isoprenoids from the Soft Coral Sarcophyton glaucum

, 2017
Five new isoprenoids, 3,4,8,16-tetra-epi-lobocrasol (1), 1,15β-epoxy-deoxysarcophine (2), 3,4-dihydro-4α,7β,8α-trihydroxy-Δ2-sarcophine (3), ent-sarcophyolide E (4), and 16-deacetyl- halicrasterol B (5) and ten known compounds 6‒15, were characterized ...
Chiung-Yao Huang, Yang-Chang Wu, Wen-Liang Li, Jyh-Horng Sheu, Chang-Feng Dai, Atallah F. Ahmed, Chih-Chuang Liaw, Mei-Chin Lu, Chih-Hua Chao   +8 more
core   +1 more source