Results 51 to 60 of about 19,561 (308)

An Intramolecular Wittig Approach toward Heteroarenes: Synthesis of Pyrazoles, Isoxazoles, and Chromenone-oximes.

Organic Letters, 2019
α-Halohydrazones/ketoximes are transformed into trisubstituted pyrazoles/disubstituted isoxazoles by treatment with phosphine, acyl chloride, and a base.
Pankaj V Khairnar, Tsai-Hui Lung, Yi-Jung Lin, Chin-Yi Wu, S. Koppolu, Athukuri Edukondalu, P. Karanam, Wenwei Lin   +7 more
semanticscholar   +1 more source

Cyclodextrin-based catalysts and molecular reactors [PDF]

, 2015
We suggest two nonparametric approaches, based on kernel methods and orthogonal series to estimating regression functions in the presence of instrumental variables. For the first time in this class of problems, we derive optimal convergence rates, and
Easton, Christopher J.
core   +1 more source

The Relationship Between Aldose Reductase and Isoxazole Derivatives: An In Vitro and In Silico Approach to Its Correlation With Diabetic Conditions

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Diabetes mellitus (DM), which can result in a number of problems such as cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular illnesses, continues to be a growing issue despite major advancements in treatment approaches.
Ahmet Esat Göner, Hatice Esra Duran
wiley   +1 more source

Regioselective synthesis of heterocyclic N-sulfonyl amidines from heteroaromatic thioamides and sulfonyl azides

Beilstein Journal of Organic Chemistry, 2020
N-Sulfonyl amidines bearing 1,2,3-triazole, isoxazole, thiazole and pyridine substituents were successfully prepared for the first time by reactions of primary, secondary and tertiary heterocyclic thioamides with alkyl- and arylsulfonyl azides.
Vladimir Ilkin, Vera Berseneva, Tetyana Beryozkina, Tatiana Glukhareva, Lidia Dianova, Wim Dehaen, Eugenia Seliverstova, Vasiliy Bakulev   +7 more
doaj   +1 more source

3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles

Molecules, 2021
In this study, 3-benzoylisoxazolines were synthesized by reacting alkenes with various α-nitroketones using chloramine-T as the base. The scope of α-nitroketones and alkenes is extensive, including different alkenes and alkynes to form various ...
Xinhui Pan, Xiaobing Xin, Ying Mao, Xin Li, Yanan Zhao, Yidi Liu, Ke Zhang, Xiaoda Yang, Jinhui Wang   +8 more
doaj   +1 more source

Copper-Catalyzed Cascade Cyclization Reactions of Diazo Compounds with tert-Butyl Nitrite and Alkynes: One-Pot Synthesis of Isoxazoles.

Journal of Organic Chemistry, 2019
A novel copper-catalyzed [3 + 2] cycloaddition reaction of alkynes with nitrile oxides generated in situ from the coupling reaction of copper carbene and nitroso radical has been developed.
Xue‐Di Wang, Lihan Zhu, Pei Liu, Xuepeng Wang, Hai-Yan Yuan, Yu‐Long Zhao   +5 more
semanticscholar   +1 more source

Iterative approach to computational enzyme design [PDF]

, 2012
A general approach for the computational design of enzymes to catalyze arbitrary reactions is a goal at the forefront of the field of protein design. Recently, computationally designed enzymes have been produced for three chemical reactions through the ...
Blomberg, Rebecca, Chica, Roberto A., Hilvert, Donald, Houk, Kendall N., Kiss, Gert, Lee, Toni M., Mayo, Stephen L., Privett, Heidi K., Thomas, Leonard M.   +8 more
core   +2 more sources

Supramolecular Aggregates of Amide‐ and Urea‐Functionalized Nanographene

ChemistryEurope, EarlyView.
The effects of amide and urea groups on the morphology, stability, and function of supramolecular NG aggregates are investigated. Amide‐functionalized NG forms stacked aggregates, whereas urea‐functionalized NG forms polymer networks, likely owing to the distinct strengths of the amide–amide and urea–urea NH/O hydrogen bonds.
Haruka Moriguchi, Ryo Sekiya, Takeharu Haino   +2 more
wiley   +1 more source

Direct Nucleophilic Difluoromethylation of Aromatic Isoxazoles Activated by Electron-Withdrawing Groups Using (Difluoromethyl)trimethylsilane

ScienceOpen Research, 2014
The activation of aromatic diaryl isoxazoles with strong electron-withdrawing groups, such as the nitro, triflyl and the phenylsulfonyl groups, at the 4-position has enabled the first regio- and diastereoselective difluoromethylation at the 5-position of
doaj   +3 more sources

5-(Benzoyloxymethyl)isoxazole-3-carboxylic Acid Ethyl Ester

Molbank
We describe here the palladium hydrogenation of ethyl 5-(benzoyloxymethyl)isoxazole-3-carboxylate. The presence of two reducible sites in the molecule, namely the benzylic-like position and the isoxazole N–O bond, creates a possible competition.
Cosimo Antonini, Franca M. Cordero, Fabrizio Machetti   +2 more
doaj   +1 more source