Results 61 to 70 of about 19,561 (308)

Ligand‐Dependent Chemoselectivity in Gold‐Catalyzed Reactions between Anthranils and Diynamides. Formation of Spiro Azacyclic Compounds versus 1‐Imino‐1H‐Indene‐3‐Carboximidamides

ChemistryEurope, EarlyView.
Gold catalysts direct anthranil/diynamide reactions: PPh3AuCl/AgNTf2 forms spiro azacycles (indole intermediate confirmed), while P(t‐Bu)2(o‐biphenyl)AuCl/AgNTf2 yields indene carboximidamides via a proposed mechanism. Gold‐catalyzed reactions between anthranils and diynamides have been investigated, and their reaction chemoselectivity relies on the ...
Satish Bhausaheb Dawange, Rai‐Shung Liu   +1 more
wiley   +1 more source

Synthesis and biological evaluation of 4-phenoxy-phenyl isoxazoles as novel acetyl-CoA carboxylase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Acetyl-CoA carboxylase (ACC) is a crucial enzyme in fatty acid metabolism, which plays a major role in the occurrence and development of certain tumours.
Xin Wu, Yongbo Yu, Tonghui Huang
doaj   +1 more source

Recent developments in chemical reactivity of N,N-dimethylenamino ketones as synthons for various heterocycles [PDF]

, 2017
The current review presents recent progress in the utility of N,N-dimethyl enaminones as building blocks for a diverse range of acyclic, carbocyclic, five- and six-membered heterocyclic a broad range of heterocyclic and fused heterocyclic derivatives ...
Abbas, Abdallah, Abdallah, Abdallah, Abdel-Khalik, Abdel-Khalik, Abdel-Khalik, Abdel-Megid, Abdel-Motaleb, Abdel-Motaleb, Abdelhamid, Abdelhamid, AbdelKhalik, Abu-Shanab, Abu-Shanab, Adams, Agamy, Agamy, Al-Awadi, Al-Awadi, Al-Awadi, Al-Enezi, Al-Etaibi, Al-Mousawi, Al-Mousawi, Al-Mousawi, Al-Mousawi, Al-Mousawi, Al-Mousawi, Al-Mousawi, Al-Omran, Al-Omran, Al-Omran, Al-Omran, Al-Omran, Al-Omran, Al-Omran, Al-Omran, Al-Saleh, Al-Saleh, Al-Saleh, Al-Saleh, Al-Saleh, Al-Saleh, Al-Saleh, Al-Saleh, Al-Shiekh, Al-Shiekh, Al-Shiekh, Al-Zaydi, Al-Zaydi, Al-Zaydi, Al-Zaydi, Al-Zaydi, Al-Zaydi, Al-Zaydi, Alinezhad, Alinezhad, Almazroa, Anwer, Behbehani, Cao, Dawood, Domínguez, El-Desoky, El-Dusouqui, El-Taweel, Eldebss, Elghamry, Farghaly, Figueiredo, Gaber, Gaber, Gaber, Gaber, Gaber, Gaber, Gad-Elkareem, Gad-Elkareem, Ghozlan, Ghozlan, Ghozlan, Gomha, Gomha, Gomha, Gomha, Gomha, Greenhill, Hassanien, Hassanien, Hassanien, Hernández, Ho, Ho, Ho, Hughes, Ibrahim, Igarashi, Ingham, Jiang, Kandeel, Kantevari, Kascheres, Katritzky, Katritzky, Kenawi, Kepe, Kepe, Kim, Kirschbaum, Liu, Lue, Macba, Macba, Makhseed, Manley, Martins, Michael, Mokhtar, Mousawi, Moustafa, Mukhanova, Murphy, Negri, Nishimura, Nishiyama, Pichon, Pigge, Pleier, Raghunadh, Rasmussen, Reidlinger, Sabnis, Saleh, Salomone, Schenone, Shaaban, Shankaraiah, Sherif, Toche, Tois, Trautwein, Verma, Wan, Wan, Wan, Wan, Wan, Wang, Witherington, Xiang, Zhao, Zhou, Šimůnek   +153 more
core   +1 more source

The Role of Five‐Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview

ChemMedChem, Accepted Article.
Over the past decades extensive scientific research in the fields of chemistry and pharmaceutical chemistry has led to the synthesis and study of numerous chemical compounds with diverse therapeutic applications. Many of these compounds feature heterocyclic aromatic structures, including six‐, five‐, and four‐membered rings.
Claudia Finamore, Carmen Festa, Rosa Barbato, Stefano Fiorucci, Angela Zampella, Simona De Marino   +5 more
wiley   +1 more source

Synthesis and Antimicrobial Activity of N′-Heteroarylidene-1-adamantylcarbohydrazides and (±)-2-(1-Adamantyl)-4-acetyl-5-[5-(4-substituted phenyl-3-isoxazolyl)]-1,3,4-oxadiazolines

Molecules, 2012
The reaction of adamantane-1-carbohydrazide (1) with heterocyclic aldehydes, namely 5-(4-chlorophenyl)isoxazole-3-carboxaldehyde (2a), 5-(4-methylphenyl)isoxazole-3-carboxaldehyde (2b), 5-(4-methoxyphenyl)isoxazole-3-carboxaldehyde (2c), 1H-imidazole-2 ...
Abdul-Malek S. Al-Tamimi, Ali A. El-Emam, Mohamed A. Al-Omar, Khalid A. Alrashood   +3 more
doaj   +1 more source

Sintesis de isoxazoles utilizando ultrasonido, para su posterior oxidacion y medicion de actividad biologica [PDF]

, 2008
63 p.Los isoxazoles presentan una gran cantidad de actividades biológicas entre las que se puede destacar actividad antifungica y antiagregante plaquetaria, entre otras, pero existen registros que las diferentes actividades biológicas de estos compuestos
Barrios Fuentes, Pedro, Vallejos Contreras, Gabriel (Prof. Guia)   +1 more
core  

Microtracer‐Based Assessment of the Mass Balance, Pharmacokinetics, and Excretion of [14C]Berzosertib, an Intravenous ATR Inhibitor, in Patients With Advanced Solid Tumors: A Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Berzosertib is a small‐molecule ataxia telangiectasia and Rad3‐related protein inhibitor. To assess the clearance mechanism(s) of berzosertib, a Phase 1, 2‐period, open‐label study was conducted in adults with advanced solid tumors who were treated with a single intravenous dose of 210 mg/m2 berzosertib containing approximately 3 µCi of [14C ...
Jayaprakasam Bolleddula, Holger Scheible, Florian Huber, Annick Seithel‐Keuth, Hanno Schieferstein, Deepthi S. Vagge, Nadra Mammasse, Eva Jaks, Jordi Ferrer, Camilo Moulin, Jennifer Dong, Karthik Venkatakrishnan, Zsuzsanna Papai   +12 more
wiley   +1 more source

Inverse electron-demand 1,3-dipolar cycloaddition of nitrile oxide with common nitriles leading to 3-functionalized 1,2,4-oxadiazoles [PDF]

, 2011
A carbamoyl-substituted nitrile oxide was generated upon treatment of easily available 2-methyl-4-nitro-3-isoxazolin-5(2H)-one with THF (not dried); the reaction proceeded efficiently even in the absence of any special reagents and reaction conditions ...
1020, 1021, 1022, 1023, 1024, 1025, 1026, 1027, Ariga, Masahiro, Hirao, Shotaro, Ise, Yumiko, Kobiro, Kazuya, Nishiwaki, Nagatoshi, Okajima, Yoshikazu, Saigo, Kazuhiko, Sawayama, Jun   +15 more
core   +1 more source

The Quinoline Photoremovable Group (PPG) Platform—A Medicinal Chemist's Approach for Photocage Development and Applications

Medicinal Research Reviews, EarlyView.
ABSTRACT Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design and mode of application have made them useful tools for studying dynamic biological processes in vitro and in vivo ...
Bence Kontra, Zoltán Mucsi, Janez Ilaš, Petra Dunkel   +3 more
wiley   +1 more source

Síntesis y evaluación “in vitro” de la actividad antifúngica de oximas, éteres de oxima e isoxazoles

Universitas Scientiarum, 2011
Synthesis and in vitro assessment of antifungal activity of oximes, oxime ethers and isoxazoles. Objective. To synthesize and carryout a preliminary evaluation of the in vitro antifungal activity of oximes, oxime ethers and isoxazoles.
John Diaz-Velandia, Natalia Durán-Díaz, Jorge Robles-Camargo, Alix Elena Loaiza   +3 more
doaj