Results 61 to 70 of about 20,504 (258)
Cyclodextrin-based catalysts and molecular reactors [PDF]
, 2015 We suggest two nonparametric approaches, based on kernel methods and orthogonal series to estimating regression functions in the presence of instrumental variables. For the first time in this class of problems, we derive optimal convergence rates, and
Easton, Christopher J.
core +1 more source
Síntesis y evaluación “in vitro” de la actividad antifúngica de oximas, éteres de oxima e isoxazoles
Universitas Scientiarum, 2011 Synthesis and in vitro assessment of antifungal activity of oximes, oxime ethers and isoxazoles. Objective. To synthesize and carryout a preliminary evaluation of the in vitro antifungal activity of oximes, oxime ethers and isoxazoles.
John Diaz-Velandia +3 more
doaj
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Acetyl-CoA carboxylase (ACC) is a crucial enzyme in fatty acid metabolism, which plays a major role in the occurrence and development of certain tumours.
Xin Wu, Yongbo Yu, Tonghui Huang
doaj +1 more source
Psychedelics, entactogens and psychoplastogens for depression and related disorders
British Journal of Pharmacology, EarlyView.Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley +1 more source
Topiramate for the treatment of neonatal seizures and beyond
Epilepsia, EarlyView.Abstract Acute symptomatic neonatal seizures are one of the most common neurological disorders in newborns admitted to neonatal intensive care units and require prompt treatment. Up to 50% of neonatal seizures are refractory to first‐line medications such as phenobarbital (PB), and another 30% fail second‐line therapy.
Wolfgang Löscher, Janet S. Soul
wiley +1 more source
Organic Letters, 2019 α-Halohydrazones/ketoximes are transformed into trisubstituted pyrazoles/disubstituted isoxazoles by treatment with phosphine, acyl chloride, and a base.
Pankaj V Khairnar +7 more
semanticscholar +1 more source
Iterative approach to computational enzyme design [PDF]
, 2012 A general approach for the computational design of enzymes to catalyze arbitrary reactions is a goal at the forefront of the field of protein design. Recently, computationally designed enzymes have been produced for three chemical reactions through the ...
Blomberg, Rebecca +8 more
core +2 more sources
Journal of Physical Organic Chemistry, Volume 38, Issue 11, November 2025.Triketone herbicides inhibit HPPD via induced fit influenced by noncovalent interactions. Using DFT‐B3LYP and NBO analysis, this study examined hydrogen and chalcogen bonds in tautomer stabilization. Results showed enolic forms with stronger intramolecular interactions, while heavier atoms like sulfur and selenium uniquely facilitated chalcogen bonds ...
Luiz dos Reis Capucho +2 more
wiley +1 more source
Organic Letters, 2019 High levels of catalyst control are demonstrated in determining the positional selectivity in C-H alkenylation of isoxazoles. A cationic rhodium-mediated, strong-directing group promotes C( sp2)-H activation at the proximal aryl ring whereas, the ...
Pravin Kumar, M. Kapur
semanticscholar +1 more source
A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene
Molecules, 2023 A novel, low-cost method for the preparation of not easily accessible free 3-aminoindoles has been developed. This approach is based on a well-established reaction between indoles and nitrostyrene in the presence of phosphorous acid, which results in the
Nicolai A. Aksenov +9 more
doaj +1 more source