Results 21 to 30 of about 8,940 (287)

tert-Butyl Nitrite-Induced Radical Nitrile Oxidation Cycloaddition: Synthesis of Isoxazole/Isoxazoline-Fused Benzo 6/7/8-membered Oxacyclic Ketones [PDF]

Molecules
A practical metal-free and additive-free approach for the synthesis of 6/7/8-membered oxacyclic ketone-fused isoxazoles/isoxazolines tetracyclic or tricyclic structures is reported through Csp3–H bond radical nitrile oxidation and the intramolecular ...
Jian-Kang Cao, Tian-Zheng Cao, Qian-Wen Yue, Ying Ma, Chuan-Ming Yang, Hong-Xi Zhang, Ya-Chen Li, Qiao-Ke Dong, Yan-Ping Zhu, Yuan-Yuan Sun   +9 more
doaj   +2 more sources

First Report of Bronchial Oestriasis in a Domestic Dog. [PDF]

Vet Med Sci
Oestrus ovis bronchial myasis is described in a dog for the first time. Bronchoscopy proved essential for larval visualization and removal. Isoxazoline compounds should be considered both as a treatment and as a preventive option. ABSTRACT This study reports the first case of bronchial myiasis in a dog caused by Oestrus ovis, a parasite known to infest
Dini FM, Raponi F, Vallone F, Galuppi R, Macchioni F.   +4 more
europepmc   +2 more sources

in silico Study Reveals Potential Docking Sites of δ 2-isoxazolines derivates for Inhibiting Russell’s Viper PLA2 Toxin [PDF]

Journal of Tropical Life Science, 2021
Snake venom phospholipase A2s (svPLA2s) has been known as the most abundant component and predominant cause of Russell’s viper envenomation. Limitation to serum therapy and considerable pharmacological interest led the researcher to syn-thesized multi ...
Tsaniyah Nur Kholilah, Widodo, Nia Kurniawan   +2 more
doaj   +1 more source

Nitrosubstituted analogs of isoxazolines and isoxazolidines: a surprising estimation of their biological activity via molecular docking.

Scientiae Radices, 2023
The biological activities in the field of antimicrobial application of trihalomethylated isoxazolines and isoxazolidines were investigated by means of molecular docking.
Karolina Zawadzińska, Bartłomiej Gostyński   +1 more
semanticscholar   +1 more source

Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

Pharmaceuticals, 2023
Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for developing novel drug candidates.
Xiyue Wang, Qingyun Hu, Hui Tang, Xinhui Pan   +3 more
doaj   +1 more source

3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles

Molecules, 2021
In this study, 3-benzoylisoxazolines were synthesized by reacting alkenes with various α-nitroketones using chloramine-T as the base. The scope of α-nitroketones and alkenes is extensive, including different alkenes and alkynes to form various ...
Xinhui Pan, Xiaobing Xin, Ying Mao, Xin Li, Yanan Zhao, Yidi Liu, Ke Zhang, Xiaoda Yang, Jinhui Wang   +8 more
doaj   +1 more source

New isoxazolidinyl-based N-alkylethanolamines as new activators of human brain carbonic anhydrases

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Carbonic anhydrases (CAs) are widespread metalloenzymes which catalyse the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3−) and a proton, relevant in many physiological processes. In the last few years, the involvement of CA activation
Doretta Cuffaro, Riccardo Di Leo, Lidia Ciccone, Alessio Nocentini, Claudiu T. Supuran, Elisa Nuti, Armando Rossello   +6 more
doaj   +1 more source

Efficacy of Oral Sarolaner for the Treatment of Feline Otodectic Mange

Pathogens, 2021
Otodectes cynotis is a mite with a cosmopolitan distribution that is the primary agent for the development of otitis externa in feline species. The aim of this study was to evaluate the efficacy of the oral administration of sarolaner for the treatment ...
Diefrey Ribeiro Campos, Jéssica Karoline de Oliveira Chaves, Brena Gava Guimarães, So Yin Nak, Gabriela Pereira Salça de Almeida, Isabela Scalioni Gijsen, Juliana de Moraes Intrieri, Fabio Barbour Scott   +7 more
doaj   +1 more source

Ultrasound-assisted one-pot three-component synthesis of new isoxazolines bearing sulfonamides and their evaluation against hematological malignancies

Ultrasonics Sonochemistry, 2021
In the present study, following a one-pot two-step protocol, we have synthesized novel sulfonamides-isoxazolines hybrids (3a-r) via a highly regioselective 1,3-dipolar cycloaddition. The present methodology capitalized on trichloroisocyanuric acid (TCCA)
Aicha Talha, Cécile Favreau, Maxence Bourgoin, Guillaume Robert, Patrick Auberger, Lahcen EL Ammari, Mohamed Saadi, Rachid Benhida, Anthony R. Martin, Khalid Bougrin   +9 more
doaj   +1 more source

Intramolecular Electrochemical Oxybromination of Olefins for the Synthesis of Isoxazolines in Batch and Continuous Flow

Annalen der Pharmacie, 2021
: A highly regioselective protocol for the synthesis of isoxazolines via cascade C-O and C-Br bond formation has been developed. The electrochemical approach uses traceless electrons as a sole source of oxidant, thus avoiding the use of stoichiometric ...
Ajit Prabhakar Kale, Pavlo Nikolaienko, K. Smirnova, M. Rueping   +3 more
semanticscholar   +1 more source