Iodoarene-catalyzed cyclizations of N-propargylamides and β-amidoketones: synthesis of 2-oxazolines
Beilstein Journal of Organic Chemistry, 2017 Two complementary iodoarene-catalyzed methods for the preparation of 2-oxazolines are presented. The first involves the cyclization of N-propargylamides and the second involves the cyclization of β-amidoketones.
Somaia Kamouka, Wesley J. Moran
doaj +1 more source
One Step Regioselective Synthesis of 5-Aminoisoxazoles from Nitrile Oxides and α-Cyanoenamines
Molecules, 2004 The 1,3-dipolar cycloaddition of nitrile oxides to 1-cyanoenamines gives 5-aminoisoxazoles regioselectively. Moderate to good yields could be obtained depending on the method used to generate the nitrile oxides. The intermediate isoxazolines could not be
Aïcha Derdour +2 more
doaj +1 more source
Synthesis, Antimicrobial and Antioxidant Activities of 2-Isoxazoline Derivatives
Molecules, 2020 A series of derivatives of trans-3-(2,4,6-trimethoxyphenyl)4,5-dihydroisoxazolo-4,5-bis[carbonyl-(4′phenyl)thiosemicarbazide (9) and of trans-3-(2,4,6-trimethoxyphenyl)-4,5-dihydro isoxazolo-4,5-bis(aroylcarbohydrazide) (10a–c) were synthesized from ...
Asma Alshamari +4 more
doaj +1 more source
Acyclic nitronate olefin cycloaddition (ANOC): regio- and stereospecific synthesis of isoxazolines
Chemical Science, 2020 We report the first demonstrations of intra- and intermolecular acyclic nitronate olefin cycloaddition (ANOC) reactions that enable the highly efficient syntheses of isoxazolines bearing various functional groups.
Liang Ma +7 more
semanticscholar +1 more source
Recent Advancements in the Control of Cat Fleas
Insects, 2020 With the advent of imidacloprid and fipronil spot-on treatments and the oral ingestion of lufenuron, the strategies and methods to control cat fleas dramatically changed during the last 25 years.
Michael K. Rust
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Organic Letters, 2019 Reported herein is an unprecedented synthesis of isoxazolines and oxazines through electrochemical intermolecular annulation of alkenes with tert-butyl nitrite, in which diazo compounds serve as radical acceptors.
Mingteng Xiong +4 more
semanticscholar +1 more source
Synthesis and Application of Bioactive N‐Functionalized Aziridines
Angewandte Chemie International Edition, EarlyView.This review discusses modern synthetic methods for the preparation of aziridine‐containing small molecules, including biocatalytic, electrocatalytic, and photocatalytic strategies. We highlight the compatibility of various synthetic methods with control of the exocyclic N‐substituent.
Hao Tan +4 more
wiley +1 more source
Gold-catalyzed propargylic substitutions: Scope and synthetic developments
Beilstein Journal of Organic Chemistry, 2011 This personal account summarizes our recent developments in gold-catalyzed direct substitutions on propargylic (allylic, benzylic) alcohols, with various nucleophiles (and bi-nucleophiles) based on the σ- and/or π-acidity of gold(III) complexes ...
Olivier Debleds +3 more
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Crystal structure of 5-(4-tert-butoxyphenyl)-3-(4-n-octyloxyphenyl)-4,5-dihydroisoxazole
Acta Crystallographica Section E: Crystallographic Communications, 2019 The molecule of the title compound, C27H37NO3, was prepared by [3 + 2] 1,3-dipolar cycloaddition of 4-n-octylphenylnitrile oxide and 4-tert-butoxystyrene, the latter compound being a very useful intermediate to the synthesis of liquid-crystalline ...
Eric S. Sales +2 more
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Inverse electron-demand 1,3-dipolar cycloaddition of nitrile oxide with common nitriles leading to 3-functionalized 1,2,4-oxadiazoles [PDF]
, 2011 A carbamoyl-substituted nitrile oxide was generated upon treatment of easily available 2-methyl-4-nitro-3-isoxazolin-5(2H)-one with THF (not dried); the reaction proceeded efficiently even in the absence of any special reagents and reaction conditions ...
1020 +15 more
core +1 more source