Results 51 to 60 of about 5,220 (174)

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1685-1695, June 2026.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

Dynamics of the kallikrein-kinin and renin-angiotensin-aldosterone systems in nephron-sparing surgical treatment of localised renal cell carcinoma

Вестник урологии
Introduction. Cancer provokes complex systemic responses, including perturbations of the kallikrein-kinin and renin-angiotensin-aldosterone systems.
N. D. Ushakova, E. M. Frantsiyants, D. A. Rozenko, N. N. Popova, A. D. Rozenko, D. S. Petrov, Yu. A. Fomenko, A. V. Shulga, A. V. Demyanenko   +8 more
doaj   +1 more source

Loss of Striatal Bradykinin B2 Receptor Alters Anxiety and Motivational Behaviors in Male Mice

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Impaired signaling of the bradykinin B2 receptor (B2R) in dorsal striatal neurons decreases anxiety‐like behavior and sucrose preference while enhancing voluntary running in mice. These results reveal a novel role for B2R in dopaminergic circuits that modulate motivation and emotional behavior.
Mariana Rosolen Tavares, Ronaldo Carvalho Araujo, Marina Galleazzo Martins, Jose Donato Jr, Michael Bader, Frederick Wasinski   +5 more
wiley   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Snake Venom Protease Detection and Inhibition in Serum

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A fluorescence assay enables sensitive detection of the activities of snake venom metalloproteases (SVMP) and serine proteases (SVSP) from viper venoms in buffer and serum. In combination with effective low‐molecular‐weight inhibitors such as ilomastat and nafamostat, this approach offers new prospects for the rapid diagnosis and adjunctive therapy of ...
Mareike Riedel, Christian Kersten
wiley   +1 more source

Investigation of ACE and DPP‐IV Inhibitory Potential of Peptides Obtained From Hazelnut Protein Hydrolysates in Food Supplement Applications

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Production of peptide molecules from hazelnut cake using proteolytic enzymes and ultrafiltration methods. Exploration of antioxidant activities, DPP‐IV and ACE inhibitory properties of these molecules and their evaluation in food supplement applications.
Sebahat Şişman, Zeynep Saliha Güneş, Bilal Çakır, İbrahim Gülseren   +3 more
wiley   +1 more source

EL ROL DEL SISTEMA CALICREÍNA-CININAS EN UN MODELO EXPERIMENTAL DE DIABETES. ESTUDIO DE LA PATOLOGÍA AÓRTICA

Revistas Argentina de Medicina, 2017
La hiperglucemia progresiva en la diabetes mellitus está asociada con daño significativo y disfunción del sistema endotelial vascular, así como con alteraciones micro y macrovasculares, permeabilidad vascular, ateroesclerosis y modificaciones del estrés
Orlando Catanzaro, Irene Di Martino, Jorgelina Aira Capponi   +2 more
doaj   +2 more sources

Imbalance of kallikrein-kinin system in chronic pancreatitis combined with obesity and results of its comprehensive correction

Gastroenterologìa, 2017
Background. Chronic pancreatitis is one of the most common diseases in general therapeutic practice. Significant role in the onset and progression of chronic pancreatitis is played by the activation of the kallikrein-kinin system (KKS), which is involved
L.S. Babinets, K.Yu. Kytsai
doaj   +1 more source

Registry‐Based Analysis of Treatment and Retreatment Attacks of Hereditary Angioedema

Clinical &Experimental Allergy, Volume 56, Issue 8, Page 986-988, August 2026.
Roman Hakl, Jan Baroš, Marta Sobotková, Radana Zachová, Pavlína Králíčková, Martina Vachová, Irena Krčmová, Michal Svoboda, Vendula Szmucová, Monika Skotáková, Jiří Litzman   +10 more
wiley   +1 more source

Serum Proteomics of Multiple Menstrual Symptoms in Female Athletes: A Pilot Study

FASEB BioAdvances, Volume 8, Issue 4, April 2026.
The graphical abstract illustrates the proteomic workflow. Serum samples and menstrual symptom questionnaire scores from female volunteers were collected at each sampling point. Two‐dimensional gel electrophoresis (2DE) images were generated from the serum, and statistical analyses that combined the questionnaire scores with the 2DE images were ...
Kai Fushimi, Tasuku Kondo, Nodoka Ikegami, Mizuki Yamada, Sing Ying Wong, Mikako Sakamaki‐Sunaga, Nobuhiro Hayashi   +6 more
wiley   +1 more source