Results 51 to 60 of about 4,951 (172)

Snake Venom Protease Detection and Inhibition in Serum

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A fluorescence assay enables sensitive detection of the activities of snake venom metalloproteases (SVMP) and serine proteases (SVSP) from viper venoms in buffer and serum. In combination with effective low‐molecular‐weight inhibitors such as ilomastat and nafamostat, this approach offers new prospects for the rapid diagnosis and adjunctive therapy of ...
Mareike Riedel, Christian Kersten
wiley   +1 more source

Dynamics of the kallikrein-kinin and renin-angiotensin-aldosterone systems in nephron-sparing surgical treatment of localised renal cell carcinoma

Вестник урологии
Introduction. Cancer provokes complex systemic responses, including perturbations of the kallikrein-kinin and renin-angiotensin-aldosterone systems.
N. D. Ushakova, E. M. Frantsiyants, D. A. Rozenko, N. N. Popova, A. D. Rozenko, D. S. Petrov, Yu. A. Fomenko, A. V. Shulga, A. V. Demyanenko   +8 more
doaj   +1 more source

Investigation of ACE and DPP‐IV Inhibitory Potential of Peptides Obtained From Hazelnut Protein Hydrolysates in Food Supplement Applications

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Production of peptide molecules from hazelnut cake using proteolytic enzymes and ultrafiltration methods. Exploration of antioxidant activities, DPP‐IV and ACE inhibitory properties of these molecules and their evaluation in food supplement applications.
Sebahat Şişman, Zeynep Saliha Güneş, Bilal Çakır, İbrahim Gülseren   +3 more
wiley   +1 more source

Registry‐Based Analysis of Treatment and Retreatment Attacks of Hereditary Angioedema

Clinical &Experimental Allergy, Volume 56, Issue 8, Page 986-988, August 2026.
Roman Hakl, Jan Baroš, Marta Sobotková, Radana Zachová, Pavlína Králíčková, Martina Vachová, Irena Krčmová, Michal Svoboda, Vendula Szmucová, Monika Skotáková, Jiří Litzman   +10 more
wiley   +1 more source

Serum Proteomics of Multiple Menstrual Symptoms in Female Athletes: A Pilot Study

FASEB BioAdvances, Volume 8, Issue 4, April 2026.
The graphical abstract illustrates the proteomic workflow. Serum samples and menstrual symptom questionnaire scores from female volunteers were collected at each sampling point. Two‐dimensional gel electrophoresis (2DE) images were generated from the serum, and statistical analyses that combined the questionnaire scores with the 2DE images were ...
Kai Fushimi, Tasuku Kondo, Nodoka Ikegami, Mizuki Yamada, Sing Ying Wong, Mikako Sakamaki‐Sunaga, Nobuhiro Hayashi   +6 more
wiley   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, Volume 12, Issue 1, Page 96-122, Spring 2026.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Proteomic Analysis of Cerebrospinal Fluid from Severe COVID‐19 Patients Reveals Prognostic Biomarkers Associated with Disease Outcome

PROTEOMICS – Clinical Applications, Volume 20, Issue 2, March 2026.
ABSTRACT Purpose Coronavirus disease 2019 (COVID‐19) has highlighted significant neurological complications in severe cases. Cerebrospinal fluid (CSF) proteomics could reveal biomarkers related to clinical outcome among critically ill patients. Experimental Design We performed high‐resolution proteomic analyses of CSF samples from 29 intensive care ...
Harry Alexopoulos, Martina Samiotaki, Eirini Gkogkou, Sofia Mavromati, Kleopatra Bitzogli, Georgios Panagiotou, Athanasios Tzioufas, Eleni Magira, Αnastasia Kotanidou, Ioannis Trougakos   +9 more
wiley   +1 more source

EL ROL DEL SISTEMA CALICREÍNA-CININAS EN UN MODELO EXPERIMENTAL DE DIABETES. ESTUDIO DE LA PATOLOGÍA AÓRTICA

Revistas Argentina de Medicina, 2017
La hiperglucemia progresiva en la diabetes mellitus está asociada con daño significativo y disfunción del sistema endotelial vascular, así como con alteraciones micro y macrovasculares, permeabilidad vascular, ateroesclerosis y modificaciones del estrés
Orlando Catanzaro, Irene Di Martino, Jorgelina Aira Capponi   +2 more
doaj   +2 more sources

Imbalance of kallikrein-kinin system in chronic pancreatitis combined with obesity and results of its comprehensive correction

Gastroenterologìa, 2017
Background. Chronic pancreatitis is one of the most common diseases in general therapeutic practice. Significant role in the onset and progression of chronic pancreatitis is played by the activation of the kallikrein-kinin system (KKS), which is involved
L.S. Babinets, K.Yu. Kytsai
doaj   +1 more source

Population Pharmacokinetic/Pharmacodynamic Modeling of Donidalorsen, an Antisense Oligonucleotide in Development for Prophylaxis of Hereditary Angioedema

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Hereditary angioedema (HAE) is a rare disorder linked to kallikrein‐kinin system dysregulation, which leads to uncontrolled activation of plasma prekallikrein. Donidalorsen is an antisense oligonucleotide designed to selectively degrade prekallikrein messenger RNA and thereby reduce prekallikrein production.
John K. Diep, Miao Liu, Pratap Singh, Steve Dorow, Danny M. Cohn, Laura Bordone, Kenneth B. Newman, Xiang Gao   +7 more
wiley   +1 more source