Results 111 to 120 of about 161,054 (247)

Deep Learning Assisted Proton Pure Shift NMR Spectroscopy. [PDF]

J Am Chem Soc
Kakita VMR, Hansen DF.
europepmc   +1 more source

Molecular structure and nickel‐binding capacity of Proteus mirabilis UreE

Acta Crystallographica Section D, EarlyView.
This study presents a 2.0 Å resolution crystal structure and determined the nickel‐binding capacity of the P. mirabilis nickel chaperone UreE. UreE is essential for the delivery of nickel to the metalloenzyme urease, which is key for the ability of P. mirabilis to cause urinary‐tract infections.UreE is a nickel chaperone that is required for the safe ...
Jiayi Pan, Sarah L. Mueller, Nuren Tasneem, Yang Wu, Emily J. Furlong   +4 more
wiley   +1 more source

Cryo-EM structures of a MexB-MexY chimeric efflux pump reveal that large open clefts are intrinsic to the MexY porter domain. [PDF]

Acta Crystallogr F Struct Biol Commun
Wang J, Tsutsumi K, Hirose M, Nakashima R, Kato T, Nishino K, Nakagawa A, Yamashita E.   +7 more
europepmc   +1 more source

Inhibition of Targeted Bacterial Growth Using MazF‐Expressing Phagemids: A Novel Therapeutic Approach Based on Endoribonuclease Toxin Molecules

Microbiology and Immunology, EarlyView.
ABSTRACT The extensive and indiscriminate use of antibiotics, which are intended to halt bacterial growth or eliminate them, has unintentionally given rise to antimicrobial resistance (AMR), which is a critical threat to global health. In the pursuit of alternative solutions, researchers have focused on type II toxin–antitoxin systems prevalent within ...
Hana Hasegawa, Tatsuki Miyamoto, Rino Isshiki, Tomoyoshi Kaneko, Kenichi Takasugi, Naohiro Noda, Satoshi Tsuneda   +6 more
wiley   +1 more source

Verification and application of an automated real-time antimicrobial susceptibility testing system: for accelerated antibiotic susceptibility testing and high-throughput screening of antibiotic synergistic effects. [PDF]

J Biol Eng
Xiao Y, Yan X, Liu Z, Fu J, Wang Z, Jiang D, Zhu H, Sun Y, Xia H, Xue C.   +9 more
europepmc   +1 more source

Overexpression of Escherichia coli yaiX Confers Multidrug Resistance and Enhances Virulence in the Silkworm Infection Model

Microbiology and Immunology, EarlyView.
ABSTRACT The emergence of bacteria with both antimicrobial resistance and high virulence has become a global health concern, underscoring the urgent need to elucidate the molecular basis underlying these traits. Here, we employed the silkworm (Bombyx mori) infection model, which is suitable for high‐throughput screening, together with an Escherichia ...
Kinuka Hongu, Kazuya Ishikawa, Tomoki Kosaki, Shin‐Ichi Miyoshi, Kazuyuki Furuta, Chikara Kaito   +5 more
wiley   +1 more source

Physiological, genetical and morphological alterations in Mycobacterium avium subsp. paratuberculosis mutants generated with the CRISPRi system. [PDF]

BMC Microbiol
Lee JH, Kyung SM, Lee ES, Xiang XR, Park HE, Shin MK, Yoo HS.   +6 more
europepmc   +1 more source

Insights from controlled, comparative experiments highlight the limitations of using BSMV and FoMV for virus‐enabled reverse genetics in rice

Annals of Applied Biology, EarlyView.
Virus‐enabled reverse genetics (VERG) enables transient gene expression modulation in plants but its efficacy varies across species. We evaluated the efficacy of barley stripe mosaic virus (BSMV) and foxtail mosaic virus (FoMV) for virus‐induced gene silencing (VIGS) and virus‐mediated overexpression (VOX) in rice (Oryza sativa).
Guilherme M. Turra, Aldo Merotto Jr., Dana R. MacGregor   +2 more
wiley   +1 more source

High-throughput analyses of a reconstituted diversity-generating retroelement identify intrinsic and extrinsic determinants of diversification. [PDF]

PLoS Genet
Unlu I, Smiley MK, Potapov V, Renoux-Martin Y, Sun ZY, Lim HC.   +5 more
europepmc   +1 more source

Structural Basis for Trivalent Cross‐Linking of a Patient‐Derived IgE Antibody by the Major Peanut Allergen Ara h 2.0201

Allergy, EarlyView.
Graphical The crystal structure of a major peanut allergen Ara h 2.0201 in a complex with a human‐derived IgE Fab fragment has been determined. The immunocomplex shows the trivalent binding of Fabs, creating a cross‐linked structure effective in the formation of large complexes on the surface of effector cells. Hydroxylation of proline has implications
Tarja Parkkinen, Heidi Heiniluoto, Janne Jänis, Kristiina Takkinen, Juha Rouvinen   +4 more
wiley   +1 more source