Results 91 to 100 of about 20,432 (180)
eLife, 2012 During meiosis, a single round of DNA replication is followed by two consecutive rounds of nuclear divisions called meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate, while sister chromatids remain together.
Matthew P Miller +3 more
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TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching. [PDF]
, 2015 The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family.
Corbett, Kevin D +5 more
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The Saccharomyces cerevisiae kinetochore
FEBS Letters, 1996 Accurate chromosome segregation is DApenDAnt on a specialized chromosomal structure, the kinetochore/centromere. The only essential constituent of the S. cerevisiae kinetochore established today is CBF3, a multisubunit complex that binds to S. cerevisiae centromere DNA.
Lechner, Johannes, Ortiz, Jennifer
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A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint
eLife, 2015 The spindle assembly checkpoint (SAC) monitors and promotes kinetochore–microtubule attachment during mitosis. Bub1 and BubR1, SAC components, originated from duplication of an ancestor gene.
Katharina Overlack +7 more
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Mechanical stability of bipolar spindle assembly
, 2016 Assembly and stability of mitotic spindle is governed by the interplay of various intra-cellular forces, e.g. the forces generated by motor proteins by sliding overlapping anti-parallel microtubules (MTs) polymerized from the opposite centrosomes, the ...
Malgaretti, Paolo, Muhuri, Sudipto
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PLoS GeneticsDuring chromosome segregation, the spindle assembly checkpoint (SAC) detects errors in kinetochore-microtubule attachments. Timely activation and maintenance of the SAC until defects are corrected is essential for genome stability.
Satya Dev Polisetty +5 more
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Kinetochore or Centromere? [PDF]
Nature, 1939 IN his recent communication1, Dr. Mather seems to have no argument against the applicability of ‘kinetochore’. He sponsors “centromere” largely because it is used by a number of investigators. But I, for one, am not convinced that it is the “best term in use to-day”. To Dr. Mather ‘centromere’ may imply a visible particle, but to many it will connote a
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PLoS GeneticsPrecise regulation of chromosome dynamics in the germline is essential for reproductive success across species. Yet, the mechanisms underlying meiotic chromosomal events such as homolog pairing and chromosome segregation are not fully understood in many ...
Clio Hockens +4 more
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Fission yeast Wee1 is required for stable kinetochore-microtubule attachment
Open BiologyWee1 is a cell cycle regulator that phosphorylates Cdk1/Cdc2 and inhibits G2/M transition. Loss of Wee1 in fission yeast results in an early onset of mitosis.
Masahiro Takado +3 more
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European Journal of Cell Biology, 2012 The multiple functions of kinetochores are reflected in their complex composition, with over a hundred different proteins, which self-associate in several functional subcomplexes. Most of these kinetochore proteins were identified over the last 10-12 years using a combination of genetic, cell biological, biochemical, and bioinformatic approaches in ...
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