Results 21 to 30 of about 20,432 (180)

How to halve ploidy : lessons from budding yeast meiosis [PDF]

, 2012
Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells.
Arumugam, Prakash, Kerr, Gary W., Sarkar, Sourav   +2 more
core   +1 more source

Phosphatases in Mitosis: Roles and Regulation

Biomolecules, 2019
Mitosis requires extensive rearrangement of cellular architecture and of subcellular structures so that replicated chromosomes can bind correctly to spindle microtubules and segregate towards opposite poles.
Margarida Moura, Carlos Conde
doaj   +1 more source

Kinetochore-bound Mps1 regulates kinetochore–microtubule attachments via Ndc80 phosphorylation [PDF]

Journal of Cell Biology, 2021
Dividing cells detect and correct erroneous kinetochore–microtubule attachments during mitosis, thereby avoiding chromosome missegregation. The Aurora B kinase phosphorylates microtubule-binding elements specifically at incorrectly attached kinetochores, promoting their release and providing another chance for proper attachments to form.
Krishna K. Sarangapani, Lori B. Koch, Christian R. Nelson, Charles L. Asbury, Sue Biggins   +4 more
openaire   +2 more sources

Exotic mitotic mechanisms [PDF]

, 2012
The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope.
Drechsler, Hauke, McAinsh, Andrew D.
core   +1 more source

Unique geometry of sister kinetochores in human oocytes during meiosis I may explain maternal age-associated increases in chromosomal abnormalities

Biology Open, 2016
The first meiotic division in human oocytes is highly error-prone and contributes to the uniquely high incidence of aneuploidy observed in human pregnancies.
Jessica Patel, Seang Lin Tan, Geraldine M. Hartshorne, Andrew D. McAinsh   +3 more
doaj   +1 more source

Co-silencing of human Bub3 and dynein highlights an antagonistic relationship in regulating kinetochore-microtubule attachments [PDF]

, 2015
We previously reported that the spindle assembly checkpoint protein Bub3 is involved in regulating kinetochore-microtubule (KT-MT) attachments. Also, Bub3 was reported to interact with the microtubule motor protein dynein.
Barisic, Efimov, Gassmann, Gassmann, Gassmann, Hassan Bousbaa, Kops, Lo, Logarinho, Logarinho, Maia, Maresca, Musacchio, Patrícia M.A. Silva, Pfarr, Reis, Rieder, Sharp, Silva, Silva, Stehman, Steuer, Uchida, Vaisberg, Varma, Waters, Yang, Álvaro A. Tavares   +27 more
core   +1 more source

Structural plasticity of the living kinetochore [PDF]

, 2017
The kinetochore is a large, evolutionarily conserved protein structure that connects chromosomes with microtubules. During chromosome segregation, outer kinetochore components track depolymerizing ends of microtubules to facilitate the separation of ...
Akiyoshi, Al-Bassam, Aravamudhan, Aravamudhan, Asbury, Biggins, Biggins, Boris Rubinstein, Brian D. Slaughter, Chan, Cheeseman, Culotti, Daniel, De Wulf, Desai, Duffy, Field, Foley, Gandhi, Gao, Gardner, Gestaut, Grishchuk, Guimaraes, Hartwell, He, Hedges, Hill, Hornung, Hornung, Jaspersen, Jay R. Unruh, Jeffrey J. Lange, Jennifer L. Gerton, Jin, Jin, Joglekar, Joglekar, Joglekar, Joglekar, Karthik Dhatchinamoorthy, Kim, Kosco, Lampert, Liu, Longtine, Mallavarapu, Malvezzi, Manjunatha Shivaraju, Mayer, McAinsh, McIntosh, McKinney, Meng, Mieck, Miller, Miranda, Ng, Obuse, Pavelka, Pearson, Pfau, Podolski, Powers, Ramey, Sarangapani, Schleiffer, Schmidt, Severin, Shivaraju, Smith, Stephens, Su, Suzuki, Tanaka, Tien, Tytell, Umbreit, Usui, van Breugel, van Hooff, Visintin, Walczak, Wang, Welburn, Westermann, Westermann, Winey, Wisniewski, Wolyniak, Yuen   +90 more
core   +1 more source

Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex [PDF]

, 2012
Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis. Kinetochore assembly is a cell cycle regulated multi-step process.
Bancroft, James M., Cardoso, M. Cristina, Deng, Wen, Diekmann, Stephan, Döring, Volker, Emmerth, Stephan, Eskat, Anja, Hellwig, Daniela, Hofmeister, Antje, Hoischen, Christian, Leonhardt, Heinrich, McAinsh, Andrew D., Meraldi, Patrick, Rudolphi, Sven, Ulbricht, Tobias   +14 more
core   +9 more sources

Prime movers : mechanochemistry of mitotic kinesins [PDF]

, 2014
Mitotic spindles are self-organizing protein machines that harness teams of multiple force generators to drive chromosome segregation. Kinesins are key members of these force-generating teams.
A Blangy, A Groen, A Hutterer, A Jannasch, A Karabay, A Toso, A Yildiz, AA Levesque, AB Asenjo, AC Groen, AE Butterfield, AF Huxley, AF Straight, AJ Roberts, AM Mulder, AM Saunders, Andrew McAinsh, AS Kashina, AS Khalil, B Gigant, B Owens, B Wickstead, BH Kwok, BH Kwok, BJ Grant, BT Schaar, C Antonio, C Hentrich, C Peters, C Thiede, C Wandke, CA Watts, CC Leduc, CE Walczak, CJ Lawrence, CK Hu, CL Parke, CL Rieder, CL Rieder, CM Whitehead, CTC Friel, CV Sindelar, CV Sindelar, D Vanneste, D Vanneste, DA Compton, E Doménech, E Karsenti, E Vladimirou, EG Sturgill, ER Hildebrandt, FJ Kull, FJ Kull, G Fink, GC Rogers, GJ Brouhard, GJ Gorbsky, GJPL Kops, H Aizawa, H Boleti, H Drechsler, H Funabiki, H Yardimci, HS Sardar, HS Sardar, HYK Kaan, I Brust-Mascher, I Brust-Mascher, I Minoura, IM Crevel, IM-TC Crevel, J Espeut, J Helenius, J Roostalu, J Roostalu, J Rosenblatt, J Stumpff, J Stumpff, J Stumpff, J Yajima, JC Cochran, JC Gatlin, JC Waters, JM Scholey, JPI Welburn, JR Aist, JR Cooper, JR McIntosh, JRJ Stout, JS Allingham, JS Weinger, K Hahlen, K Jaqaman, K Kaseda, K Kaseda, K Samejima, KE Gascoigne, KJ Verhey, KS Burbank, KW Wood, KW Wood, KY Lee, L Wordeman, LC Kapitein, LC Kapitein, LN Weaver, LR Sproul, M Braun, M Braun, M Glotzer, M Joshi, M Kikkawa, M Klejnot, M Mishima, M Nishiyama, M Wagenbach, MA Hoyt, MA Seeger, MC Alonso, ME Douglas, ME Tanenbaum, ME Tanenbaum, ME Tanenbaum, MI Mayr, MJ Korneev, ML Gupta, MT Valentine, MT Valentine, N Gudimchuk, N Hirokawa, N Hirokawa, N Joseph, NF Endres, NJ Carter, NJ Ganem, OO Rath, P Bieling, Q Chang, R Nitta, R Nunes Bastos, R Uehara, RB Case, RD Vale, Robert A. Cross, S Acar, S Cai, S Cane, S Debonis, S Diez, S Dumont, S Highsmith, S Inoué, S Oh, S Rice, S Rice, S Shastry, SF Bakhoum, SS Rosenfeld, SS Rosenfeld, SW Grill, T Krzysiak, T Maney, T Surrey, TJ Mitchison, TJ Mitchison, TM Kapoor, TT Ogawa, V Fridman, V Magidson, V Mountain, V Varga, VV Bormuth, W Saunders, WW Wang, X Su, X Su, Y Du, Y Kim, Y Kurasawa, Y Oguchi, Y Zhai, YF Dufrene, YM Lee, YY Okada, Z Yang   +184 more
core   +1 more source

Human Shugoshin Mediates Kinetochore-Driven Formation of Kinetochore Microtubules [PDF]

Cell Cycle, 2006
The conserved protein Shugoshin (Sgo) plays a role in the maintenance of centromeric cohesion in mitosis and meiosis. Human Shugoshin (hSgo) was first identified as an overexpressed protein in breast cancers. Here we demonstrate that hSgo mediates kinetochore-driven formation of kinetochore -microtubules (MTs) during bipolar spindle assembly.
Hideaki, Suzuki, Nobutake, Akiyama, Megumi, Tsuji, Toya, Ohashi, Saburo, Saito, Yoshikatsu, Eto   +5 more
openaire   +2 more sources