Results 31 to 40 of about 20,432 (180)
Mitotic centromere-associated kinesin (MCAK) : a potential cancer drug target [PDF]
, 2011 The inability to faithfully segregate chromosomes in mitosis results in chromosome instability, a hallmark of solid tumors. Disruption of microtubule dynamics contributes highly to mitotic chromosome instability.
Friel, Claire T. +4 more
core +2 more sources
Evidence of Zip1 Promoting Sister Kinetochore Mono-orientation During Meiosis in Budding Yeast
G3: Genes, Genomes, Genetics, 2018 Halving of the genome during meiosis I is achieved as the homologous chromosomes move to the opposite spindle poles whereas the sister chromatids stay together and move to the same pole.
Hemant Kumar Prajapati +3 more
doaj +1 more source
Cell Reports, 2020 Summary: Kinetochores are multi-protein machines that form dynamic attachments to microtubules and control chromosome segregation. High fidelity is ensured because kinetochores can monitor attachment status and tension, using this information to activate
Emanuele Roscioli +7 more
doaj +1 more source
Checkpoint proteins come under scrutiny [PDF]
, 2013 Details are emerging of the interactions between the kinetochore and various spindle checkpoint proteins that ensure that sister chromatids are equally divided between daughter cells during cell ...
Millar, Jonathan B. A. +1 more
core +1 more source
Cell Reports, 2019 Summary: The spindle assembly checkpoint (SAC) delays anaphase onset until sister chromosomes are bound to microtubules from opposite spindle poles. Only then can dynamic microtubules produce tension across sister kinetochores.
Kathleen G. Proudfoot +6 more
doaj +1 more source
Influence of M-phase chromatin on the anisotropy of microtubule asters [PDF]
, 1996 In many eukaryotic cells going through M-phase, a bipolar spindle is formed by microtubules nucleated from centrosomes. These microtubules, in addition to being "captured" by kinetochores, may be stabilized by chromatin in two different ways: short-range
Dogterom, M. +3 more
core +2 more sources
Biology Open, 2017 Kinetochores move chromosomes on dynamic spindle microtubules and regulate signaling of the spindle checkpoint. The spindle- and kinetochore-associated (Ska) complex, a hexamer composed of two copies of Ska1, Ska2 and Ska3, has been implicated in both ...
Sushama Sivakumar, Gary J. Gorbsky
doaj +1 more source
Evidence of Non-microtubule Spindle Forces in Mesostoma ehrenbergii Spermatocytes
Frontiers in Molecular Biosciences, 2020 We tested conclusions reached in previous experiments in which Mesostoma spermatocyte chromosomes moved rapidly to a pole in the absence of microtubules: after 10 μM nocodazole (NOC) depolymerized metaphase spindle microtubules, kinetochores from each of
Eleni Fegaras-Arch +3 more
doaj +1 more source
Mad2, Bub3, and Mps1 regulate chromosome segregation and mitotic synchrony in Giardia intestinalis, a binucleate protist lacking an anaphase-promoting complex. [PDF]
, 2014 The binucleate pathogen Giardia intestinalis is a highly divergent eukaryote with a semiopen mitosis, lacking an anaphase-promoting complex/cyclosome (APC/C) and many of the mitotic checkpoint complex (MCC) proteins.
Cande, W Zacheus, Vicente, Juan-Jesus
core +2 more sources
An assay for de novo kinetochore assembly reveals a key role for the CENP-T pathway in budding yeast
eLife, 2018 Chromosome segregation depends on the kinetochore, the machine that establishes force-bearing attachments between DNA and spindle microtubules. Kinetochores are formed every cell cycle via a highly regulated process that requires coordinated assembly of ...
Jackie Lang +2 more
doaj +1 more source