Results 51 to 60 of about 20,432 (180)

Super-resolution kinetochore tracking reveals the mechanisms of human sister kinetochore directional switching

eLife, 2015
The congression of chromosomes to the spindle equator involves the directed motility of bi-orientated sister kinetochores. Sister kinetochores bind bundles of dynamic microtubules and are physically connected through centromeric chromatin.
Nigel J Burroughs, Edward F Harry, Andrew D McAinsh   +2 more
doaj   +1 more source

Histone H1 is essential for mitotic chromosome architecture and segregation in Xenopus laevis egg extracts. [PDF]

, 2005
During cell division, condensation and resolution of chromosome arms and the assembly of a functional kinetochore at the centromere of each sister chromatid are essential steps for accurate segregation of the genome by the mitotic spindle, yet the ...
Freedman, Benjamin S, Heald, Rebecca, Maresca, Thomas J   +2 more
core   +2 more sources

Loss of function of the Cik1/Kar3 motor complex results in chromosomes with syntelic attachment that are sensed by the tension checkpoint. [PDF]

PLoS Genetics, 2012
The attachment of sister kinetochores by microtubules emanating from opposite spindle poles establishes chromosome bipolar attachment, which generates tension on chromosomes and is essential for sister-chromatid segregation.
Fengzhi Jin, Hong Liu, Ping Li, Hong-Guo Yu, Yanchang Wang   +4 more
doaj   +1 more source

Splicing factors Sf3A2 and Prp31 have direct roles in mitotic chromosome segregation [PDF]

, 2018
Several studies have shown that RNAi-mediated depletion of splicing factors (SFs) results in mitotic abnormalities. However, it is currently unclear whether these abnormalities reflect defective splicing of specific pre-mRNAs or a direct role of the SFs ...
Alushin, Antrobus, Auckland, Beyer, Blower, Blower, Bobkov, Bonaccorsi, Buffin, Burns, Buttrick, Chase, Ciferri, Conduit, De Renzis, DeLuca, DeLuca, Feijão, Giansanti, Giansanti, Giansanti, Giet, Goshima, Goto, Grenfell, Grenfell, Guilgur, Hanisch, Harel, Hayward, Heeger, Helgeson, Herold, Hofmann, Hofmann, Huranová, Janczyk, Khodor, Kiseleva, Kittler, Lehner, Liu, Maslon, Montembault, Neumann, Nguyen, Pacheco, Peretz, Przewloka, Raffa, Renda, Rogers, Roscioli, Rošić, Schittenhelm, Schweizer, Sharp, Shin, Silljé, Somma, Somma, Sundaramoorthy, Tadros, Takenaka, Tanenbaum, Toso, van der Lelij, Varma, Venkei, Vernì, Walker, Williams, Williams, Wu, Zalokar   +74 more
core   +1 more source

Kinetochore structure: electron spectroscopic imaging of the kinetochore. [PDF]

The Journal of cell biology, 1989
The structure of the kinetochore in thin section has been studied in the Indian muntjac by an electron spectroscopic imaging technique. This procedures allows the analysis of the distribution of phosphorus within the layers of the kinetochore. The results indicate that this element is a major component of both the inner and outer plates whereas it is ...
J B, Rattner, D P, Bazett-Jones
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Fin1-PP1 Helps Clear Spindle Assembly Checkpoint Protein Bub1 from Kinetochores in Anaphase

Cell Reports, 2016
Summary: The spindle assembly checkpoint (SAC) monitors chromosome attachment defects, and the assembly of SAC proteins at kinetochores is essential for its activation, but the SAC disassembly process remains unknown.
Michael Bokros, Curtis Gravenmier, Fengzhi Jin, Daniel Richmond, Yanchang Wang   +4 more
doaj   +1 more source

Nuclear-localized subtype of end-binding 1 protein regulates spindle organization in Arabidopsis [PDF]

, 2010
End-binding 1 (EB1) proteins are evolutionarily conserved plus-end-tracking proteins that localize to growing microtubule plus ends where they regulate microtubule dynamics and interactions with intracellular targets.
Abe, Tatsuya, Coutuer, Silvie, Hashimoto, Takashi, Inzé, Dirk, Komaki, Shinichiro, Russinova, Eugenia   +5 more
core   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source