Results 71 to 80 of about 20,432 (180)
Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores
Nature Communications, 2016 During metaphase, k-fibre microtubules exert force on kinetochores, but there are also non-kinetochore microtubules close to kinetochores without a known function.
Janko Kajtez +17 more
doaj +1 more source
Mechanisms to Avoid and Correct Erroneous Kinetochore-Microtubule Attachments
Biology, 2017 In dividing vertebrate cells multiple microtubules must connect to mitotic kinetochores in a highly stereotypical manner, with each sister kinetochore forming microtubule attachments to only one spindle pole.
Michael A. Lampson +1 more
doaj +1 more source
Adventures of the undead at kinetochores
Molecular & Cellular Oncology, 2021 At the metaphase-to-anaphase transition, phosphatase activity feeds back to reverse early mitotic phosphorylation events. Our recent work indicates that the pseudokinase domain of the spindle checkpoint protein BUB1 (Budding Uninhibited by Benzimidazoles
Sabine Elowe
doaj +1 more source
Kinetochore inactivation by expression of a repressive mRNA. [PDF]
, 2017 Differentiation programs such as meiosis depend on extensive gene regulation to mediate cellular morphogenesis. Meiosis requires transient removal of the outer kinetochore, the complex that connects microtubules to chromosomes.
Chen, Jingxun +8 more
core +2 more sources
Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2
Nature Communications, 2016 The spindle assembly checkpoint relies on the accumulation of Mad1-Mad2 at kinetochores, but the mechanism of regulation is not known. Here Zhou et al.
Haining Zhou +4 more
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Dissecting mitosis by RNAi in Drosophila tissue culture cells
Biological Procedures Online, 2003 Here we describe a detailed methodology to study the function of genes whose products function during mitosis by dsRNA-mediated interference (RNAi) in cultured cells of Drosophila melanogaster.
Maiato Helder +2 more
doaj +1 more source
Complete microtubule–kinetochore occupancy favours the segregation of merotelic attachments [PDF]
, 2018 Kinetochores are multi-protein complexes that power chromosome movements by tracking microtubules plus-ends in the mitotic spindle. Human kinetochores bind up to 20 microtubules, even though single microtubules can generate sufficient force to move ...
Dudka, Damian +5 more
core +2 more sources
MAD1: Kinetochore Receptors and Catalytic Mechanisms
Frontiers in Cell and Developmental Biology, 2018 The mitotic checkpoint monitors kinetochore-microtubule attachment, delays anaphase onset and prevents aneuploidy when unattached or tensionless kinetochores are present in cells.
Yibo Luo, Ejaz Ahmad, Song-Tao Liu
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Mechanisms mitigating problems with multiple kinetochores on one microtubule in early mitosis [PDF]
, 2017 Proper chromosome segregation in mitosis relies on correct kinetochore interaction with spindle microtubules. In early mitosis, each kinetochore usually interacts with the lateral side of each microtubule and is subsequently tethered at the microtubule ...
Amberg +39 more
core +3 more sources
Nature Communications, 2019 How the chromosome passenger complex (CPC) phosphorylates the kinetochores that can be a micron away to control mitotic events is unknown. Here the authors find that the CPC directly binds microtubules near inner centromeres, which controls its ability ...
Prasad Trivedi +5 more
doaj +1 more source