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Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations
Frontiers in Aging, 2022 The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened lifespan, stunted growth, renal disease, hyperphosphatemia, hypercalcemia ...
Gérald J. Prud’homme +4 more
doaj +2 more sources
A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling
Nature Communications, 2022 Loss of Klotho, an anti-aging protein, plays a critical role in the pathogenesis of chronic kidney diseases. As Klotho is a large transmembrane protein, it is challenging to harness it as a therapeutic remedy.
Qian Yuan, Li Li, Yuan Tian
exaly +2 more sources
Anti-Inflammatory Role of the Klotho Protein and Relevance to Aging
CellsThe α-Klotho protein (hereafter Klotho) is an obligate coreceptor for fibroblast growth factor 23 (FGF23). It is produced in the kidneys, brain and other sites. Klotho insufficiency causes hyperphosphatemia and other anomalies.
Gérald J. Prud’homme, Qinghua Wang
doaj +2 more sources
Cell Death and Disease, 2023 Degenerative changes of the retinal pigment epithelium (RPE) triggered by transforming growth factor-β2 (TGF-β2) and oxidative stress play a critical role in the progression of age-related macular degeneration (AMD).
Ha Young Jang +3 more
doaj +2 more sources
Current understanding of klotho [PDF]
Ageing Research Reviews, 2009 Klotho is a new anti-aging gene. Genetic mutation of klotho causes multiple premature aging-like phenotypes and strikingly shortens lifespan. Overexpression of the klotho gene in mice suppresses aging and extends lifespan which may involve the mechanism of suppression of insulin signaling and oxidant stress.
Zhongjie Sun
exaly +3 more sources
Frontiers in Aging Neuroscience, 2023 PurposeAging is the primary risk factor for cognitive decline. Serum klotho, as an anti-aging protein, may be involved in cognitive decline. Thus, we aim to explorer the correlation between serum klotho and cognitive performance among an older adult ...
Deng Linghui +5 more
doaj +2 more sources
Association between methylmalonic acid and Alpha-Klotho in American adults: A cross-sectional study. [PDF]
PLoS OneBao R +6 more
europepmc +2 more sources
The association between serum soluble α-Klotho and thyroid profile among adults from NHANES 2007–2012 [PDF]
BMC Endocrine DisordersBackground Thyroid hormone is the key endocrine regulator of growth, development, metabolism, and other bodily functions. α-Klotho has been involved in the aging process and acts as an endocrine factor involved in the regulation of various metabolic ...
Jing Dong +5 more
doaj +2 more sources
Frontiers in Psychiatry, 2021 Background: Recent literature suggests that α-Klotho, a widely recognized anti-aging protein, is involved in longevity as well as in many diseases, including Alzheimer's disease, and depression.
Xiang Gao +11 more
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Klotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease
Antioxidants, 2023 Reducing oxidative stress stands at the center of a prevention and control strategy for mitigating cellular senescence and aging. Kidney disease is characterized by a premature aging syndrome, and to find a modulator targeting against oxidative stress ...
J. Donate-Correa +4 more
semanticscholar +1 more source