Results 1 to 10 of about 14,696 (214)

Klotho, Aging, and the Failing Kidney [PDF]

Frontiers in Endocrinology, 2020
Klotho has been recognized as a gene involved in the aging process in mammals for over 30 years, where it regulates phosphate homeostasis and the activity of members of the fibroblast growth factor (FGF) family. The α-Klotho protein is the receptor for Fibroblast Growth Factor-23 (FGF23), regulating phosphate homeostasis and vitamin D metabolism ...
Buchanan, S., Combet, E., Stenvinkel, P., Shiels, P.G.   +3 more
openaire   +5 more sources

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

NRF2 signalling in cytoprotection and metabolism

British Journal of Pharmacology, EarlyView., 2023
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi   +4 more
wiley   +1 more source

Klotho and Renal Fibrosis [PDF]

Nephro-Urology Monthly, 2013
Klotho is a newly discovered protein with pleotropic effects and have affected different fields of renal medicine from translational research to clinical nephrology. Here we want to summarize some new scopes in the field of renal fibrosis and Klotho with this hope that in future it could be implemented as a new therapeutic strategy to combat the renal ...
Parisa Nikasa, Sepide Zununi Vahed, Mohammadreza Ardalan   +2 more
openaire   +3 more sources

Growth hormone and Klotho [PDF]

Journal of Endocrinology, 2013
Acromegaly is characterized by excessively high GH and IGF1 levels. Recent data suggest that soluble Klotho (sKlotho) is also elevated in patients with active acromegaly. sKlotho decreases towards normal following removal of the GH-producing pituitary adenoma. TheKlothogene was identified in mice following its accidental disruption by ectopic DNA.
Schmid, Christoph, Neidert, Marian C, Tschopp, Oliver, Sze, Lisa, Bernays, René L   +4 more
openaire   +2 more sources

Interaction of Klotho and sirtuins

Experimental Gerontology, 2023
In this article, we review the articles that have reported the interaction between Klotho and sirtuins.Sirtuins are a family of histone deacetylase enzymes that are considered to be the main regulators of biological processes. This family is one of the essential factors for postponing aging and increasing the life span of organisms.
Farzaneh Rostamzadeh, Yasamin Moosavi-Saeed, Mahboobeh Yeganeh-Hajahmadi   +2 more
openaire   +3 more sources

Soluble Klotho causes hypomineralization in Klotho-deficient mice [PDF]

Journal of Endocrinology, 2018
The type I transmembrane protein αKlotho (Klotho) serves as a coreceptor for the phosphaturic hormone fibroblast growth factor 23 (FGF23) in kidney, while a truncated form of Klotho (soluble Klotho, sKL) is thought to exhibit multiple activities, including acting as a hormone, but whose mode(s) of action in different organ systems remains to be fully ...
Minamizaki, Tomoko, Konishi, Yukiko, Sakurai, Kaoru, Yoshioka, Hirotaka, Aubin, Jane E., Kozai, Katsuyuki, Yoshiko, Yuji   +6 more
openaire   +4 more sources

Klotho and the Treatment of Human Malignancies [PDF]

Cancers, 2020
Klotho was first discovered as an anti-ageing protein linked to a number of age-related disease processes, including cardiovascular, renal, musculoskeletal, and neurodegenerative conditions. Emerging research has also demonstrated a potential therapeutic role for Klotho in cancer biology, which is perhaps unsurprising given that cancer and ageing share
Irene Chong, Irene Chong, Christos Kontovounisios, Alan Ashworth, Jerome Gouge, Stella Nikolaou, Aishani Sachdeva, Kenneth Lim   +7 more
openaire   +7 more sources

Klotho [PDF]

Journal of the American Society of Nephrology, 2011
Ectopic calcification of the vasculature comes with age and is also prevalent in patients with chronic kidney disease (CKD). Klotho, a protein highly expressed in the kidney, has been identified as a novel anti-aging factor,[1][1],[2][2] and Klotho-deficient animals develop medial ...
Shroff, Rukshana, Shanahan, Catherine M.
openaire   +3 more sources

Shedding of klotho by ADAMs in the kidney [PDF]

American Journal of Physiology-Renal Physiology, 2015
The anti-aging gene klotho plays an important role in Ca2+and phosphate homeostasis. Membrane-bound klotho is an essential coreceptor for fibroblast growth factor-23 and can be cleaved by proteases, including a disintegrin and metalloproteinase (ADAM)10 and ADAM17.
Loon, E.P.M. van, Pulskens, W.P.C., Hagen, E.A.E. van der, Lavrijsen, M., Vervloet, M.G., Goor, H. van, Bindels, R.J.M., Hoenderop, J.G.J.   +7 more
openaire   +6 more sources