Results 21 to 30 of about 14,696 (214)
Klotho is upregulated in human cardiomyopathy independently of circulating Klotho levels [PDF]
Scientific Reports, 2018 AbstractKlotho is an antiaging protein which exerts known cardioprotection. In kidney, trans-membrane Klotho acts as essential co-receptor of fibroblast growth factor 23 (FGF23). In the heart, soluble Klotho (sKlotho) protects from systolic dysfunction independently of FGF23.
G. Poelzl +9 more
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Current understanding of klotho [PDF]
Ageing Research Reviews, 2009 Klotho is a new anti-aging gene. Genetic mutation of klotho causes multiple premature aging-like phenotypes and strikingly shortens lifespan. Overexpression of the klotho gene in mice suppresses aging and extends lifespan which may involve the mechanism of suppression of insulin signaling and oxidant stress.
Zhongjie Sun, Yuhong Wang
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Kidney International, 2011 Klotho is a putative aging suppressor gene encoding a single-pass transmembrane co-receptor that makes the fibroblast growth factor (FGF) receptor specific for FGF-23. In addition to multiple endocrine organs, Klotho is expressed in kidney distal convoluted tubules and parathyroid cells, mediating the role of FGF-23 in bone-kidney-parathyroid control ...
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The vascular secret of Klotho [PDF]
Kidney International, 2015 Klotho is an evolutionarily highly conserved protein related to longevity. Increasing evidence of a vascular protecting effect of the Klotho protein has emerged and might be important for future treatments of uremic vascular calcification. It is still disputed whether Klotho is locally expressed in the vasculature or whether its vascular effects arise ...
Ewa Lewin, Klaus Olgaard
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Cell Death and Disease, 2023 Degenerative changes of the retinal pigment epithelium (RPE) triggered by transforming growth factor-β2 (TGF-β2) and oxidative stress play a critical role in the progression of age-related macular degeneration (AMD).
Ha Young Jang +3 more
doaj +1 more source
Soluble klotho as an effective biomarker to characterize inflammatory states
Annals of Medicine, 2022 Background & Aims Soluble α-Klotho (s-Klotho) is a circulating protein with pleiotropic effects that mainly induce protective effects. Our study investigates the associations between s-Klotho and several established inflammatory biomarkers, with the aim ...
Shou-En Wu, Wei-Liang Chen
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The Role and Molecules Mechanism of Klotho in Renal Injury in Salt-sensitive Hypertension [PDF]
Zhongguo quanke yixue, 2023 Background Klotho is closely related to the occurrence and development of kidney disease. Salt-sensitive hypertension (SSH) is often accompanied by kidney disease.
ZHAO Wei, TANG Rongjie, YANG Shanshan, YANG Fang, SUN Feng, LIAN Qiufang
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Scientific Reports, 2021 The Naked Mole Rat (NMR), Heterocephalus glaber, provides an interesting model for studying biomarkers of longevity due to its long lifespan of more than 30 years, almost ten times longer than that of mice and rats.
M. Morevati +10 more
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Research progress on the role of Klotho in heart failure [PDF]
Jichu yixue yu linchuang, 2023 Klotho is an anti-aging protein and can be divided into three types: full-length transmembrane Klotho, soluble Klotho and secreted Klotho. Many studies have shown that Klotho is closely related to oxidative stress, inflammatory response, myocardial ...
CHAI Yaru, DENG Yuting, DAI Hongyan, GUAN Jun
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Soluble α-Klotho Serum Levels in Chronic Kidney Disease
International Journal of Endocrinology, 2015 Transmembrane α-Klotho (TM-Klotho), expressed in renal tubules, is a cofactor for FGF23-receptor. Circulating soluble-α-Klotho (s-Klotho) results from TM-Klotho shedding and acts on Phosphate (P) and Calcium (Ca) tubular transport.
Silverio Rotondi +8 more
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