Results 21 to 30 of about 33,787 (326)
Retinoic acid induces hyaluronic acid production through the klotho-mediated EGFR signaling pathway in human epidermal keratinocytes [PDF]
Archives of Biological Sciences, 2022 All-trans retinoic acid (RA) is an effective anti-aging chemical substance widely used in skin-care products. RA compromises epidermal differentiation and induces keratinocyte proliferation, causing hyaluronic acid production through mechanisms that are ...
Choi Hyangtae +4 more
doaj +1 more source
Soluble Klotho causes hypomineralization in Klotho-deficient mice [PDF]
Journal of Endocrinology, 2018 The type I transmembrane protein αKlotho (Klotho) serves as a coreceptor for the phosphaturic hormone fibroblast growth factor 23 (FGF23) in kidney, while a truncated form of Klotho (soluble Klotho, sKL) is thought to exhibit multiple activities, including acting as a hormone, but whose mode(s) of action in different organ systems remains to be fully ...
Minamizaki, Tomoko +6 more
openaire +4 more sources
Klotho and vitamin D in multiple sclerosis: an Italian study [PDF]
, 2020 Introduction Low vitamin D levels have been recognised as an important risk factor for autoimmune diseases, including multiple sclerosis (MS). MS is a multifactorial disease, the pathogenesis of which contributes both to genetic and environmental ...
Bruna Lo Sasso +10 more
core +1 more source
Scientific Reports, 2021 The Naked Mole Rat (NMR), Heterocephalus glaber, provides an interesting model for studying biomarkers of longevity due to its long lifespan of more than 30 years, almost ten times longer than that of mice and rats.
M. Morevati +10 more
doaj +1 more source
Molecular Metabolism, 2021 Objective: Our laboratory recently identified the centrally circulating α-klotho protein as a novel hypothalamic regulator of food intake and glucose metabolism in mice. The current study aimed to investigate novel molecular effectors of central α-klotho
Taylor Landry +9 more
doaj +1 more source
Klotho’s impact on diabetic nephropathy and its emerging connection to diabetic retinopathy
Frontiers in Endocrinology, 2023 Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide and is a significant burden on healthcare systems. α-klotho (klotho) is a protein known for its anti-aging properties and has been shown to delay the onset of age-related
A. Tang +8 more
semanticscholar +1 more source
Clinical Kidney Journal, 2023 Klotho, a multifunctional protein, acts as a co-receptor in fibroblast growth factor 23 and exerts its impact through various molecular pathways, including Wnt, hypoxia-inducible factor and insulin-like growth factor 1 pathways.
M. Kanbay +7 more
semanticscholar +1 more source
Research Models for Studying Vascular Calcification [PDF]
, 2020 Calcification of the vessel wall contributes to high cardiovascular morbidity and mortality. Vascular calcification (VC) is a systemic disease with multifaceted contributing and inhibiting factors in an actively regulated process.
Babic, Milen +4 more
core +1 more source
Soluble klotho as an effective biomarker to characterize inflammatory states
Annals of Medicine, 2022 Background & Aims Soluble α-Klotho (s-Klotho) is a circulating protein with pleiotropic effects that mainly induce protective effects. Our study investigates the associations between s-Klotho and several established inflammatory biomarkers, with the aim ...
Shou-En Wu, Wei-Liang Chen
doaj +1 more source
Translational Psychiatry, 2023 The relationships of Klotho levels with cognition and dementia are poorly understood. This study aimed to investigate the association between Klotho levels and cognitive function and to determine causality between Klotho and dementia using Mendelian ...
Yue Wu +5 more
semanticscholar +1 more source