Results 31 to 40 of about 14,696 (214)
Failure to maintain full-term pregnancies in pig carrying klotho monoallelic knockout fetuses
BMC Biotechnology, 2021 Background Small animals that show a deficiency in klotho exhibit extremely shortened life span with multiple aging-like phenotypes. However, limited information is available on the function of klotho in large animals such as pigs.
Sanghoon Lee +9 more
doaj +1 more source
Circulating Klotho levels: clinical relevance and relationship with tissue Klotho expression [PDF]
Kidney International, 2013 Klotho is a protein that exerts paracrine and endocrine functions. In chronic kidney disease (CKD), its expression is decreased in several tissues. This decrease probably plays important roles in various complications associated with CKD, in both a fibroblast growth factor-23 (FGF23)-dependent and an FGF23-independent manner.
Ziad A. Massy +2 more
openaire +2 more sources
microRNA-200c regulates KLOTHO expression in human kidney cells under oxidative stress.
PLoS ONE, 2019 KLOTHO deficiency is associated with the progression of kidney dysfunction, whereas its overexpression exerts renoprotective effects. Oxidative stress suppresses KLOTHO expression in renal epithelial cells but upregulates microRNA-200c (miR-200c) in ...
Kenichi Morii +8 more
doaj +1 more source
Klotho to Treat Kidney Fibrosis [PDF]
Journal of the American Society of Nephrology, 2013 Sixteen years ago, defective expression of the murine klotho gene was found to result in a syndrome resembling human aging.[1][1] Tubular kidney cells were the main sites of Klotho expression.
Alberto Ortiz +2 more
openaire +3 more sources
International Journal of Cell Biology, 2020 Antiaging protein Klotho exhibits impressive properties of anti-inflammation, however is declined early after intervertebral disc injury, making Klotho restoration an attractive strategy of treating intervertebral disc inflammatory disorders.
Fangfang Bi +4 more
doaj +1 more source
The Organ Handling of Soluble Klotho in Humans
Kidney & Blood Pressure Research, 2019 Background: Chronic kidney disease (CKD) reduces both Klotho expression and its shedding into circulation, an effect that accelerates progression and cardiovascular complications.
Daniela Picciotto +10 more
doaj +1 more source
Serum α-Klotho associated with oral health among a nationally representative sample of US adults
Frontiers in Endocrinology, 2022 BackgroundLow klotho is associated with aging-related traits. However, no study has assessed the association between klotho and oral health in a large sample of population.
Guo-Qiang Chen +5 more
doaj +1 more source
Effects of klotho protein or klotho knockdown in porcine oocytes at different stages
Zygote, 2023 SummaryKlotho is a protein that plays different functions in female fertility. We have previously reported that klotho protein supplementation during in vitro maturation improves porcine embryo development, while klotho knockout for somatic cell cloning completely blocks full-term pregnancy in vivo.
Eun Pyo Kim +5 more
openaire +2 more sources
Frontiers in Cellular Neuroscience, 2019 The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular ...
Dongxue Li +5 more
doaj +1 more source
Plasma S-Klotho level affects the risk of hyperuricemia in the middle-aged and elderly people
European Journal of Medical Research, 2022 Background Soluble Klotho (S-Klotho) is an anti-aging protein mainly secreted by the kidneys. Hyperuricemia is prevalent among middle-aged and elderly individuals, which affects the development of various chronic diseases.
Haitao Xie +9 more
doaj +1 more source