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BMC Geriatrics, 2023 Background Frailty is common and not limited to older age group. Serum α-Klotho works as a biomarker of anti-aging effect. However, there is limited research about the relationship between them in middle-aged and older people and controversy still exists.
Zewei Jiang +4 more
semanticscholar +1 more source
FGF23-klotho axis as predictive factors of fractures in type 2 diabetics with early chronic kidney disease [PDF]
, 2020 Background: The aim of our study was to evaluate the relevance of FGF23-klotho axis in the predisposition for bone fractures in type 2 diabetic patients with early chronic kidney disease.
Ana Luísa Ribeiro +52 more
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Klotho and Renal Fibrosis [PDF]
Nephro-Urology Monthly, 2013 Klotho is a newly discovered protein with pleotropic effects and have affected different fields of renal medicine from translational research to clinical nephrology. Here we want to summarize some new scopes in the field of renal fibrosis and Klotho with this hope that in future it could be implemented as a new therapeutic strategy to combat the renal ...
Zununi Vahed, Sepide +2 more
openaire +2 more sources
Gla-rich protein (GRP) as an early and novel marker of vascular calcification and kidney dysfunction in diabetic patients with CKD: a pilot cross-sectional study [PDF]
, 2020 Vascular calcification (VC) is one of the strongest predictors of cardiovascular risk in chronic kidney disease (CKD) patients. New diagnostic/prognostic tools are required for early detection of VC allowing interventional strategies.
Almeida, Edgar de +12 more
core +1 more source
Soluble α-Klotho Serum Levels in Chronic Kidney Disease
International Journal of Endocrinology, 2015 Transmembrane α-Klotho (TM-Klotho), expressed in renal tubules, is a cofactor for FGF23-receptor. Circulating soluble-α-Klotho (s-Klotho) results from TM-Klotho shedding and acts on Phosphate (P) and Calcium (Ca) tubular transport.
Silverio Rotondi +8 more
doaj +1 more source
American Journal of Nephrology, 2023 Introduction: Kidney stones (KSs) are associated with hematuria and renal failure and pose a significant clinical and public health concern. Diabetes is associated with a higher risk of KSs.
Yuxiuzi Xiao, Zuo Xiao
semanticscholar +1 more source
Biochimica et Biophysica Acta (BBA) - General Subjects, 2009 The klotho gene encodes a single-pass transmembrane protein that forms a complex with multiple fibroblast growth factor (FGF) receptors and functions as an obligatory co-receptor for FGF23, a bone-derived hormone that induces negative phosphate balance.
openaire +2 more sources
Frontiers in Endocrinology, 2023 Introduction Klotho is an anti-aging protein that reduces adiposity and increases caloric expenditure, among others. Although associations between secreted α-Klotho levels and obesity have been described, its relationship with central obesity and ...
G. Carreras-Badosa +10 more
semanticscholar +1 more source
Autoimmune hyperphosphatemic tumoral calcinosis in a patient with FGF23 autoantibodies [PDF]
, 2018 Hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is an autosomal recessive disorder of ectopic calcification due to deficiency of or resistance to intact fibroblast growth factor 23 (iFGF23). Inactivating
Burbelo +14 more
core +1 more source
Cardiovascular Diabetology, 2023 Objective Diabetic kidney disease (DKD) is characterized by the abnormal deposition of oxidized low-density lipoprotein (ox-LDL), which contributes to podocyte damage. Klotho, an aging suppressor that plays a critical role in protecting podocytes in DKD,
Wei Jiang +10 more
semanticscholar +1 more source