Results 61 to 70 of about 14,696 (214)
Scientific ReportsKlotho regulates many pathways in the aging process, but it remains unclear how it is physiologically regulated. Because Klotho is synthesized, cleaved, and released from the kidney; activates the chief urinary K+ secretion channel (ROMK) and stimulates ...
Hyun Jun Jung +9 more
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Frontiers in Aging Neuroscience, 2023 PurposeAging is the primary risk factor for cognitive decline. Serum klotho, as an anti-aging protein, may be involved in cognitive decline. Thus, we aim to explorer the correlation between serum klotho and cognitive performance among an older adult ...
Deng Linghui +5 more
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European Journal of Clinical Investigation, EarlyView.Our research shows different post‐surgical patters in GDF15 and FGF21 concentrations following Roux‐en‐Y gastric bypass. GDF15 levels increase significantly in patients with obesity and normoglycemia and in those with obesity and impaired glucose tolerance or type 2 diabetes, while FGF21 concentrations significantly decrease in patients with obesity ...
Laura Salmón‐Gómez +12 more
wiley +1 more source
The role of Klotho in energy metabolism [PDF]
Nature Reviews Endocrinology, 2012 A disproportionate expansion of white adipose tissue and abnormal recruitment of adipogenic precursor cells can not only lead to obesity but also impair glucose metabolism, which are both common causes of insulin resistance and diabetes mellitus. The development of novel and effective therapeutic strategies to slow the progression of obesity, diabetes ...
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EBioMedicine, 2019 Background: The klotho (KL) gene is an anti-aging gene that has recently been shown to also function as a general tumor suppressor. However, there is currently only limited information regarding the potential molecular signals for regulation of Klotho ...
Bo Chen +10 more
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Renal Failure, 2023 Background Peritoneal fibrosis caused by long-term peritoneal dialysis (PD) is the main reason why patients withdraw from PD treatment. Lipid accumulation in the peritoneum was shown to participate in fibrosis, and klotho is a molecule involved in lipid ...
Qinglian Wang +3 more
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Molecular mechanism for transcriptional regulation of the parathyroid hormone gene by Epiprofin
The FEBS Journal, EarlyView.The secretion of parathyroid hormone (PTH) from the chief cells in the parathyroid glands is regulated by the concentration of extracellular calcium. Epiprofin (Epfn) expression is induced by NFATc2 in response to elevated serum calcium, and Epfn negatively regulates PTH production.
Takashi Nakamura +8 more
wiley +1 more source
Klotho and Chronic Kidney Disease [PDF]
, 2013 Through alternative splicing, Klotho protein exists both as a secreted and a membrane form whose extracellular domain could be shed from the cell surface by secretases and released into the circulation to act as endocrine factor. Unlike membrane Klotho which functions as a coreceptor for fibroblast growth factor-23 (FGF23) to modulate FGF23 signal ...
Ming Chang Hu +2 more
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Anti-Inflammatory Role of the Klotho Protein and Relevance to Aging
CellsThe α-Klotho protein (hereafter Klotho) is an obligate coreceptor for fibroblast growth factor 23 (FGF23). It is produced in the kidneys, brain and other sites. Klotho insufficiency causes hyperphosphatemia and other anomalies.
Gérald J. Prud’homme, Qinghua Wang
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Upregulation of the Creatine Transporter Slc6A8 by Klotho
Kidney & Blood Pressure Research, 2014 Background/Aims: The transmembrane Klotho protein contributes to inhibition of 1,25(OH)2D3 formation. The extracellular domain of Klotho protein could function as an enzyme with e.g. β-glucuronidase activity, be cleaved off and be released into blood and
Ahmad Almilaji +8 more
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