Results 61 to 70 of about 33,787 (326)
Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study [PDF]
, 2007 BACKGROUND: Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span. METHODS:We conducted a genome wide association study (Affymetrix 100K SNP GeneChip) for longevity-related traits in a ...
Benjamin, Emelia J +11 more
core +6 more sources
Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549
Journal of Experimental & Clinical Cancer Research, 2010 Background Klotho, as a new anti-aging gene, can shed into circulation and act as a multi-functional humoral factor that influences multiple biological processes.
Zhao Weihong +3 more
doaj +1 more source
Research progress on the role of Klotho in heart failure [PDF]
Jichu yixue yu linchuang, 2023 Klotho is an anti-aging protein and can be divided into three types: full-length transmembrane Klotho, soluble Klotho and secreted Klotho. Many studies have shown that Klotho is closely related to oxidative stress, inflammatory response, myocardial ...
CHAI Yaru, DENG Yuting, DAI Hongyan, GUAN Jun
doaj +1 more source
Journal of Diabetes Research, 2023 Objective Deficiencies in klotho are implicated in various kidney dysfunctions including diabetic nephropathy (DN) related to inflammatory responses. Klotho is closely related to inflammatory responses and is a potential target for ameliorating kidney ...
Jiaxin He +8 more
semanticscholar +1 more source
Journal of the American Society of Nephrology, 2011 Ectopic calcification of the vasculature comes with age and is also prevalent in patients with chronic kidney disease (CKD). Klotho, a protein highly expressed in the kidney, has been identified as a novel anti-aging factor,[1][1],[2][2] and Klotho-deficient animals develop medial ...
Shroff, Rukshana, Shanahan, Catherine M.
openaire +3 more sources
Vitamin D. a dynamic molecule. how relevant might the dynamism for a vitamin be [PDF]
, 2015 Cholecalciferol, the precursor of Vitamin D3, is a very old, highly conserved, molecule. Its presence is evident in non-mineralized 750 million-year-old living species, such as plankton.
Mazzaferro, Sandro, Pasquali, Marzia
core +2 more sources
Klotho is upregulated in human cardiomyopathy independently of circulating Klotho levels [PDF]
Scientific Reports, 2018 AbstractKlotho is an antiaging protein which exerts known cardioprotection. In kidney, trans-membrane Klotho acts as essential co-receptor of fibroblast growth factor 23 (FGF23). In the heart, soluble Klotho (sKlotho) protects from systolic dysfunction independently of FGF23.
G. Poelzl +9 more
openaire +2 more sources
PLoS ONE, 2020 Klotho is an age-extending, cognition-enhancing protein found to be down-regulated in aged mammals when age-related diseases start to appear. Low levels of Klotho occur in neurodegenerative diseases, kidney disease and many cancers.
Ci-Di Chen +7 more
doaj +1 more source
Translational Andrology and Urology, 2023 Background Sepsis-associated acute kidney injury (SA-AKI) is a common complication of sepsis and greatly increases patient mortality. Recombinant human Klotho protein (Klotho) is a protective protein that can be secreted by the kidney.
Pan Zhou +5 more
semanticscholar +1 more source
Circulating Klotho levels: clinical relevance and relationship with tissue Klotho expression [PDF]
Kidney International, 2013 Klotho is a protein that exerts paracrine and endocrine functions. In chronic kidney disease (CKD), its expression is decreased in several tissues. This decrease probably plays important roles in various complications associated with CKD, in both a fibroblast growth factor-23 (FGF23)-dependent and an FGF23-independent manner.
Drüeke, Tilman B., Massy, Ziad A.
openaire +2 more sources