Results 71 to 80 of about 14,696 (214)
Journal of Internal Medicine, EarlyView.Abstract Background and Objectives This population‐based study explores associations of fibroblast growth factor 21 (FGF21), a key modulator of processes linked to protein metabolism, with protein intake and muscle mass, and their relationships with all‐cause mortality.
Adrian Post +5 more
wiley +1 more source
Clinical Interventions in Aging, 2015 Aging is an inevitable and progressive biological process involving dysfunction and eventually destruction of every tissue and organ. This process is driven by a tightly regulated and complex interplay between genetic and acquired factors. Klotho is an antiaging gene encoding a single-pass transmembrane protein, klotho, which serves as an aging ...
Ming Chang Hu +3 more
openaire +5 more sources
Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients
International Journal of Endocrinology, 2015 Klotho is a single-pass transmembrane protein predominantly expressed in the kidney. The extracellular domain of Klotho is subject to ectodomain shedding and is released into the circulation as a soluble form.
Naoko Otani-Takei +10 more
doaj +1 more source
BMC Nephrology, 2012 Background Klotho is a single-pass transmembrane protein, which appears to be implicated in aging. The purpose of the present study was to characterize the relationship between the soluble Klotho level and renal function in patients with various degrees ...
Akimoto Tetsu +15 more
doaj +1 more source
Nutrition Bulletin, EarlyView.ABSTRACTHealthy midlife cognitive function (CF) reduces the risk of later cognitive decline. Emerging evidence suggests that chrono‐nutrition may be associated with CF. This cross‐sectional cohort study aimed to examine associations between chrono‐nutrition behaviours and CF in adults aged 45–65 years living in Cyprus.
Christiana A. Demetriou +12 more
wiley +1 more source
Hyperaldosteronism in Klotho-deficient mice
American Journal of Physiology-Renal Physiology, 2010 Klotho is a membrane protein participating in the inhibitory effect of FGF23 on the formation of 1,25-dihydroxyvitamin-D3 [1,25(OH)2D3]. It participates in the regulation of renal tubular phosphate reabsorption and stimulates renal tubular Ca2+ reabsorption. Klotho hypomorphic mice ( klotho hm) suffer from severe growth deficit, rapid aging, and early
Berthold Hocher +13 more
openaire +5 more sources
Di-san junyi daxue xuebao, 2020 Objective To investigate the association of serum klotho level with renal function deterioration and whether serum klotho level can be used as a predictor of progression of chronic kidney disease (CKD) into renal end point events.
YANG Jiangxin +3 more
doaj +1 more source
Experimental Physiology, EarlyView.Abstract Chronic kidney disease–mineral and bone disorder (CKD‐MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease.
Alief Waitupu +4 more
wiley +1 more source
The Protective Role of Klotho in CKD-Associated Cardiovascular Disease
Kidney Diseases, 2020 Background: Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in advanced CKD. The major pathological changes of CKD-associated CVD are severe vascular media calcification, aberrant cardiac remodeling such as hypertrophy and
Xianjin Bi +3 more
doaj +1 more source
Experimental Physiology, EarlyView.Abstract The mood stabilizers lithium and valproate are psychotropic medications widely used in clinical practice. Despite their proven benefits, many individuals stop their treatment due to the adverse effects. Chronic diarrhoea is a common reason for discontinuation of these drugs; however, the underlying mechanisms are unknown.
Sofia Cussotto +10 more
wiley +1 more source