Results 71 to 80 of about 33,787 (326)
Frontiers in Endocrinology, 2023 Objective The Klotho protein is a well-documented anti-aging protein known for its diverse biological functions. Hyperlipidemia is an established independent risk factor for various chronic diseases.
Shaohua Yan +4 more
semanticscholar +1 more source
Indonesian Biomedical Journal, 2022 BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD). Klotho expression was reduced in patients with CKD, leading to vascular calcification, endothelial dysfunction, and atherosclerosis.
Hendri Susilo +8 more
doaj +1 more source
International Journal of Molecular Sciences, 2023 Depression is a serious neuropsychiatric disease affecting an increasing number of people worldwide. Cognitive deficits (including inattention, poor memory, and decision-making difficulties) are common in the clinical picture of depression.
P. Pańczyszyn-Trzewik +3 more
semanticscholar +1 more source
Circulation, 2012 Finding the mechanism that will make us live a long and healthy life is the goal of medical research. How appropriate that Klotho, the Greek goddess of life is involved in vascular disease. Klotho is one of the Greek Moirai, the goddesses of fate who controlled the ultimate destiny of man: death.
openaire +2 more sources
Nefrología, 2019 Background: Klotho is found in two forms: a transmembrane form and a soluble form (s-Klotho). In order to be excreted, s-Klotho, that is too large to be filtered, will probably reach the proximal convoluted tubule by a transcytosis process.
Flaviu Bob +14 more
doaj +3 more sources
Frontiers in Cellular Neuroscience, 2019 The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular ...
Dongxue Li +5 more
doaj +1 more source
Klotho antiaging protein: molecular mechanisms and therapeutic potential in diseases
Molecular BiomedicineKlotho, initially introduced as an anti-aging protein, is expressed in the brain, pancreas, and most prominently in the kidney. The two forms of Klotho (membrane-bound and soluble form) have diverse pharmacological functions such as anti-inflammatory ...
Aditya Dipakrao Hajare +2 more
semanticscholar +1 more source
Individual nutrients and serum klotho levels in adults aged 40–79 years
Food Science & Nutrition, 2023 Several dietary factors (including adherence to the Mediterranean diet or higher nut intake) seem to positively affect circulating antiaging Klotho protein levels; yet, a description of possible relationships between individual nutrients and Klotho ...
S. Ostojić +4 more
semanticscholar +1 more source
Nutrients, 2023 Background: Klotho is an aging-related marker closely associated with a number of diseases. A growing body of evidence suggests that dietary factors and lifestyle habits can impact serum Klotho levels.
Si-Yun Liu +6 more
semanticscholar +1 more source
Failure to maintain full-term pregnancies in pig carrying klotho monoallelic knockout fetuses
BMC Biotechnology, 2021 Background Small animals that show a deficiency in klotho exhibit extremely shortened life span with multiple aging-like phenotypes. However, limited information is available on the function of klotho in large animals such as pigs.
Sanghoon Lee +9 more
doaj +1 more source