Results 81 to 90 of about 33,787 (326)

Klotho-derived peptide 1 inhibits cellular senescence in the fibrotic kidney by restoring Klotho expression via posttranscriptional regulation

Theranostics
Background: Klotho deficiency is a common feature of premature aging and chronic kidney disease (CKD). As such, restoring Klotho expression could be a logic strategy for protecting against various nephropathies.
Xiaoyao Zhang, Li Li, H. Tan, Xue Hong, Q. Yuan, Fan Fan Hou, Lili Zhou, Youhua Liu   +7 more
semanticscholar   +1 more source

Lower serum Klotho level and higher systemic immune-inflammation index: an inverse correlation

BMC Geriatrics, 2023
Objectives Klotho, an anti-aging protein, has been identified to control tissue inflammatory responses. The objective of this research is to determine the linkage between soluble Klotho (S-Klotho) level and systemic immune-inflammation index (SII ...
Ping Chen, Yafen Tang, Liang Luo, Haotian Chen, Xingkang He   +4 more
semanticscholar   +1 more source

Physiological conditions influencing regenerative potential of stem cells [PDF]

, 2016
Stem cells are being used in the treatment of cardivovascular diseases. Here, we review the physiologic and pathologic conditions that impact the regenerative potential of stem cells in the treatment of cardiovascular diseases which include the influence
Avitabile, Daniele, De Falco, Elena, Gambini, Elisa, Spaltro, Gabriella   +3 more
core   +1 more source

New insights into the role of Klotho in inflammation and fibrosis: molecular and cellular mechanisms

Frontiers in Immunology
As the body’s defense mechanism against damage and infection, the inflammatory response is a pathological process that involves a range of inflammatory cells and cytokines.
Xinyue Zhao, Donghe Han, Chun Zhao, Fengfan Yang, Zhimei Wang, Yujiao Gao, Meihua Jin, Ran Tao   +7 more
semanticscholar   +1 more source

Neuroprotective Role of Klotho on Dementia

Cureus, 2023
Klotho, a gene found on chromosome 13q12, is involved in a variety of processes and signaling pathways in the human body related to vitamin D metabolism; cardiovascular, renal, musculoskeletal, and skin diseases; and cancer biology.
F. N. Ananya, Md Ripon Ahammed, S. Lahori, Charmy Parikh, Jannel A. Lawrence, Fnu Sulachni, Tawfiq Barqawi, C. Kamwal   +7 more
semanticscholar   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

The role of FGF23/Klotho in mineral metabolism and chronic kidney disease [PDF]

, 2013
Chronic kidney disease (CKD) is a global health burden of growing incidence and prevalence. As renal function declines disturbances in mineral metabolism, such as hyperphosphatemia and secondary hyperparathyroidism, inevitably develop. These metabolic
Olauson, Hannes
core   +1 more source

Overexpression of klotho suppresses growth and pulmonary metastasis of osteosarcoma in vivo

Genetics and Molecular Biology
Klotho is originally discovered as an anti-aging gene and knock-out of klotho accelerates aging in mice. Subsequent studies support the anti-carcinogenesis role of klotho in a variety of human malignancies.
Ying Li, Hai-jun Xiao, Feng Xue
doaj   +1 more source

Upregulation of the Creatine Transporter Slc6A8 by Klotho

Kidney & Blood Pressure Research, 2014
Background/Aims: The transmembrane Klotho protein contributes to inhibition of 1,25(OH)2D3 formation. The extracellular domain of Klotho protein could function as an enzyme with e.g. β-glucuronidase activity, be cleaved off and be released into blood and
Ahmad Almilaji, Mentor Sopjani, Bernat Elvira, José Borras, Miribane Dërmaku-Sopjani, Carlos Munoz, Jamshed Warsi, Undine E. Lang, Florian Lang   +8 more
doaj   +1 more source

Plasma S-Klotho level affects the risk of hyperuricemia in the middle-aged and elderly people

European Journal of Medical Research, 2022
Background Soluble Klotho (S-Klotho) is an anti-aging protein mainly secreted by the kidneys. Hyperuricemia is prevalent among middle-aged and elderly individuals, which affects the development of various chronic diseases.
Haitao Xie, Ning Li, Guowei Zhou, Qian Liu, Haiyan Wang, Jie Han, Le Shen, Peng Yu, Jiandong Chen, Xiaohu Chen   +9 more
doaj   +1 more source