Results 81 to 90 of about 14,696 (214)

Alpha Klotho and phosphate homeostasis [PDF]

Journal of Endocrinological Investigation, 2014
The Klotho family consists of three single-pass transmembrane proteins—αKlotho, βKlotho and γKlotho. Each of them combines with fibroblast growth factor (FGF) receptors (FGFRs) to form receptor complexes for various FGF’s. αKlotho is a co-receptor for physiological FGF23 signaling and appears essential for FGF23-mediated regulation of mineral ...
Changying Xing, Ming Chang Hu, Ao Bian
openaire   +2 more sources

Oxyntomodulin physiology and its therapeutic development in obesity and associated complications

The Journal of Physiology, EarlyView.
Abstract figure legend Physiological influences of OXM and its emerging insights from evidence on bariatric surgery effects. CCK, cholecystokinin; FGF21, fibroblast growth factor 21; GLUT4, glucose transporter type 4; IRS1, insulin receptor substrate‐1; NNMT, nicotinamide N‐methyltransferase; OXM, oxyntomodulin Abstract Incretins, such as glucagon‐like
Martin T. W. Kueh, Ming Chuen Chong, Alexander D. Miras, Carel W. le Roux   +3 more
wiley   +1 more source

Exosomes, autophagy, and cancer: A complex triad

International Journal of Cancer, Volume 157, Issue 3, Page 405-415, 1 August 2025.
Abstract Cancer remains one of the leading causes of death worldwide. Despite remarkable progress in prevention, diagnosis, and therapy, the incidence of certain types of cancer persists, urging the identification of clinically relevant biomarkers and the development of novel therapeutic strategies to improve clinical outcomes and overcome treatment ...
María Guerra‐Andrés, Álvaro F. Fernández, Tania Fontanil   +2 more
wiley   +1 more source

Lower serum Klotho level and higher systemic immune-inflammation index: an inverse correlation

BMC Geriatrics, 2023
Objectives Klotho, an anti-aging protein, has been identified to control tissue inflammatory responses. The objective of this research is to determine the linkage between soluble Klotho (S-Klotho) level and systemic immune-inflammation index (SII ...
Ping Chen, Yafen Tang, Liang Luo, Haotian Chen, Xingkang He   +4 more
doaj   +1 more source

The transcription factor RIP140 regulates interferon γ signaling in breast cancer

International Journal of Cancer, Volume 157, Issue 1, Page 170-182, 1 July 2025.
What's new? Interferon γ (IFNγ) is a key player in breast cancer, with the potential to induce apoptosis and to shift tumors into a dormant state. However, it also may promote carcinogenesis and angiogenesis. In this study, transcriptomic analysis identified the transcription factor RIP140 as a key regulator of IFNγ signaling in breast cancer.
Stéphan Jalaguier, Axel Kuehn, Chloé Petitpas, Arnaud Dulom, Rémy Jacquemont, Cindy Assi, Sophie Sixou, Udo Jeschke, Jacques Colinge, Vincent Cavaillès   +9 more
wiley   +1 more source

Klotho, an anti-aging gene, acts as a tumor suppressor and inhibitor of IGF-1R signaling in diffuse large B cell lymphoma

Journal of Hematology & Oncology, 2017
Background Klotho, is a transmembrane protein, performs as a circulating hormone and upstream modulator of the insulin-like growth factor-1 receptor (IGF-1R), fibroblast growth factor (FGF), and Wnt signaling pathways.
Xiangxiang Zhou, Xiaosheng Fang, Yujie Jiang, Lingyun Geng, Xinyu Li, Ying Li, Kang Lu, Peipei Li, Xiao Lv, Xin Wang   +9 more
doaj   +1 more source

Calcinosis cutis of the lower legs – hyperphosphatemic familial tumoral calcinosis in a patient with GALNT3 mutation

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
David Ranzinger, Tobias Schaefer, Franziska Schauer, Kilian Eyerich, Anna Caroline Pilz   +4 more
wiley   +1 more source

Fibroblast Growth Factor 23 and Sarcopenia in Maintenance Haemodialysis Population

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.
ABSTRACT Background Sarcopenia is defined as the loss of muscle mass, strength, and/or performance. It is strongly associated with all‐cause mortality. Fibroblast growth factor 23 (FGF23) is markedly elevated in patients with chronic kidney disease, especially those receiving maintenance dialysis.
Limy Wong, Rachel Kenny, Jenny Y. Y. Ooi, Yung Shing Tsang, Emily Schembri, Lawrence P. McMahon   +5 more
wiley   +1 more source

Obesity‐related glomerulopathy: How it happens and future perspectives

Diabetic Medicine, Volume 42, Issue 6, June 2025.
Abstract Obesity‐related glomerulopathy (ORG) is an emerging complication of excess adiposity. Its incidence rises alongside the obesity pandemic. Up to 40% of individuals can be affected by ORG, irrespective of the status of glomerular filtration rate and albuminuria.
Jian‐Wen Samuel Lee‐Boey, Jia‐Kai Tan, Zhan‐Foong Lim, Francesco Zaccardi, Kamlesh Khunti, Majid Ezzati, Edward W. Gregg, Lee‐Ling Lim   +7 more
wiley   +1 more source

FGF2 Mediated USP42‐PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

Advanced Science, Volume 12, Issue 18, May 15, 2025.
USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang, Qiang Tian, Zhenli Lei, Shuxin Wang, Nan Cheng, Zhen Wang, Xianqin Jiang, Xuqun Zheng, Wenjing Xu, Minyan Ye, Longwei Zhao, Meiyun Wen, Jianlou Niu, Weijian Sun, Pingping Shen, Zhifeng Huang, Xiaokun Li   +16 more
wiley   +1 more source