Results 61 to 70 of about 402 (139)

The neurobiological mechanism underlying hypothalamic GnRH pulse generation: the role of kisspeptin neurons in the arcuate nucleus [version 1; peer review: 4 approved]

F1000Research, 2019
This review recounts the origins and development of the concept of the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator. It starts in the late 1960s when striking rhythmic episodes of luteinizing hormone secretion, as reflected by ...
Tony M. Plant
doaj   +1 more source

Report on the 13th international workshop on the CCN family of genes and inaugural ARBIOCOM conference, Nice, France

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Celebration of the 13th ICCNS meeting joint to the 1st ARBIOCOM Conference held on the site of Nice in December 2025. Abstract The 13th International Workshop on the CCN Family of Genes, held in Nice as part of the inaugural ARBIOCOM World Conference, brought together investigators with diverse research backgrounds, disciplines, and expertise. Building
Bernard Perbal, Ralf Weiskirchen, Annick Perbal, Brahim Chaqour   +3 more
wiley   +1 more source

Menopausal hormone therapy and comprehensive postmenopausal care in gynecologic cancer survivors: A position paper from the FIGO Committee on Women at Menopausal Age

International Journal of Gynecology &Obstetrics, Volume 174, Issue 3, Page 1151-1171, September 2026.
Abstract Recent advances in cancer screening, diagnosis, and treatment have greatly improved survival rates among women with gynecologic cancers. More survivors now live long enough to experience treatment‐related menopause. Vasomotor symptoms, genitourinary syndrome of menopause, sexual dysfunction, sleep issues, and long‐term risks from estrogen ...
Agnaldo Lopes da Silva‐Filho, Suvarna Khadilkar, Hema Divakar, Chiara Benedetto, Andrea R. Genazzani, Diana Ramos, Elizabete Argale, Enrique Herrera, Martha Hickey   +8 more
wiley   +1 more source

Effects of chrysin on Kisspeptin, neurokinin B, and dynorphin neurons and gonadotropin-releasing hormone gene expression in stress-induced rats: An experimental study

International Journal of Reproductive BioMedicine
Background: A subpopulation of neurons known as Kisspeptin, neurokinin B, and dynorphin (KNDy) are located in the hypothalamus. These neurons co-express and release the corresponding neuropeptides.
Khadijeh Haghighat, Fariba Mahmoudi, Homayoun Khazali   +2 more
doaj   +1 more source

Central Injection of Substance P Antagonizes the RF Amide-Related Peptide-3 Impacts on Hypothalamic KISS-1 and GnRH Gene Expressions in Male Wistar Rats [PDF]

International Journal of Basic Science in Medicine, 2018
Introduction: Gonadotropin-inhibitory hormone (GnIH) and its mammalian orthologue RF amide-related peptide (RFRP) are known to inhibit the secretion of gonadotropins. In addition, substance P (SP), a member of tachykinin’s family, can increase the firing
Parastoo Rahdar, Homayoun Khazali
doaj   +1 more source

Fertility outcomes and ovarian function recovery after anti‐NMDAR encephalitis: A retrospective cohort study

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 9, Page 1823-1832, September 2026.
Acute hypothalamic–pituitary–ovarian axis suppression is common in anti‐NMDAR encephalitis, yet ovarian function and fertility recover favorably even in teratoma‐associated cases, supporting reassuring long‐term reproductive prognoses. Abstract Introduction Anti‐N‐methyl‐D‐aspartate receptor (anti‐NMDAR) encephalitis predominantly affects women of ...
Jia Wang, Jie Ding, Han Cai, YingXiang Wang, HaoTian Wu   +4 more
wiley   +1 more source

Periestropause enhances hypoxia‐induced panic and microglial remodelling without altering respiratory control

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Abstract Perimenopause is characterised by irregular reproductive cycles and hormonal fluctuations, notably decreased estradiol (E2), which are linked to increased susceptibility to panic disorder and neuroinflammation. We examined whether panic‐related respiratory and behavioural responses to respiratory challenges vary across reproductive stages ...
Angela Cristina Nicola, Luana Tenório‐Lopes, Luis Gustavo A. Patrone, Mariana Bernardes‐Ribeiro, Heloisa H. Vilela‐Costa, Daniele Gandra, Ana Clara Campideli‐Santana, Raphael E. Szawka, Kênia C. Bícego, Rita Cássia M. Dornelles, Luciane H. Gargaglioni   +10 more
wiley   +1 more source

Reproductive neuropeptides:Prevalence of GnRH and KNDy neural signalling components in a model avian, gallus gallus

, 2013
Diverse external and internal environmental factors are integrated in the hypothalamus to regulate the reproductive system. This is mediated through the pulsatile secretion of GnRH into the portal system to stimulate pituitary gonadotrophin secretion ...
Millar, Robert, Joseph, Nerine, Bedecarrats, Gregoy, Tello, Javier, Tello, Javier; id_orcid   +4 more
core   +1 more source

Absence of sex differences in diabetes-induced suppression of KNDy neurons in rats

Journal of Endocrinology
Diabetes mellitus disturbs kisspeptin–neurokinin B–dynorphin A (KNDy) neurons in the arcuate nucleus (ARC), which regulate pulsatile luteinizing hormone (LH) secretion in both sexes. However, it remains unclear whether a sex-specific association with the negative effects of diabetes on KNDy neurons exists.
Mai Otsuka, Kinuyo Iwata, Yuki Otsuka, Yoshihisa Uenoyama, Hitoshi Ozawa, Hirotaka Ishii   +5 more
openaire   +4 more sources

Optical control of the hypothalamic arcuate nucleus kisspeptin neuronal network with a photoswitchable peptide that drives luteinizing hormone release in female mice

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Abstract Pulsatile gonadotropin‐releasing hormone (GnRH) and luteinizing hormone (LH) secretion are essential for reproductive function and are thought to be governed by arcuate nucleus kisspeptin Kiss1ARH neurons via neurokinin B (NKB) signaling through TacR3.
Jian Qiu, Yanyan Lin, Emily Bartram, Janelle M. Tobias, Antonio Muñoz, Xiao Feng Li, Victoria S. Halls, James A. Frank, Martin J. Kelly, Kevin T. O'Byrne   +9 more
wiley   +1 more source