Results 11 to 20 of about 20,173 (272)

Importance of Modulating Kynurenic Acid Metabolism—Approaches for the Treatment of Dementia [PDF]

Biomolecules
In this article, we focus on kynurenic acid metabolism in neuropsychiatric disorders and the biochemical processes involved in memory and cognitive impairment, followed by different approaches in the fight against dementia.
Halina Baran, Marcelin Jan Pietryja, Berthold Kepplinger   +2 more
doaj   +2 more sources

Novel Activity of Oral Hypoglycemic Agents Linked with Decreased Formation of Tryptophan Metabolite, Kynurenic Acid [PDF]

Life
Kynurenic acid is a tryptophan (Trp) metabolite formed along the kynurenine (KYN) pathway in the brain and in peripheral tissues. The disturbed formation of kynurenic acid, which targets glutamate-mediated neurotransmission, GPR35, and aryl hydrocarbon ...
Kinga Bednarz, Kamila Kozieł, Ewa M. Urbańska   +2 more
doaj   +2 more sources

Selective heterofunctionalization of kynurenic acid derivatives [PDF]

RSC Advances
The current study presents selective halogenation of kynurenic acid analogues and further transformation thereof.
Levente Törteli, Péter Simon, Róbert Berkecz, István Szatmári   +3 more
openaire   +2 more sources

LC-MS/MS Detection of Tryptophan, Kynurenine, Kynurenic Acid, and Quinolinic Acid in Urine Samples from Drug-Positive and Illicit Drug-Negative Patients with a Known History of Substance Use Disorder [PDF]

Metabolites
Introduction: Currently, there are few tools for monitoring recovery in substance use disorder. As substance use has increased in prevalence, tools for measuring recovery are needed to improve therapeutic outcomes.
Lindsey Contella, Christopher L. Farrell, Luigi Boccuto, Alain H. Litwin, Hunter Flanagan, Stacy E. F. Melanson, Nicole V. Tolan, Marion L. Snyder, Dina N. Greene   +8 more
doaj   +2 more sources

Determination of Bioactive Compound Kynurenic Acid in Linum usitatissimum L. [PDF]

Molecules
Kynurenic acid (KYNA) is a bioactive compound exhibiting multiple actions and positive effects on human health due to its antioxidant, anti-inflammatory and neuroprotective properties.
Magdalena Wróbel-Kwiatkowska, Waldemar Turski, Grażyna Silska, Magdalena Rakicka-Pustułka, Lucyna Dymińska, Waldemar Rymowicz   +5 more
doaj   +2 more sources

Kynurenic Acid Is a Predictive Prognostic Metabolic Marker in ST‐Elevation Myocardial Infarction [PDF]

Cardiovasc Ther
Xiaolin Zhang, Miaohan Qiu, Kun Na, Ming‐Huei Cheng, Haixu Song, N. Zhao, Dan Liu, Chenghui Yan, Yaling Han   +8 more
openalex   +2 more sources

Effect of kynurenic acid on enzymatic activity of the DNA base excision repair pathway in specific areas of the sheep brain [PDF]

Sci Rep
Patrycja Młotkowska, Tomasz Misztal, Paweł Kowalczyk, Elżbieta Marciniak   +3 more
europepmc   +3 more sources

Activation of BDNF-TrkB Signaling in Specific Structures of the Sheep Brain by Kynurenic Acid [PDF]

Cells
Katarzyna Roszkowicz-Ostrowska, Patrycja Młotkowska, Elżbieta Marciniak, Michał Szlis, Marcin Barszcz, Tomasz Misztal   +5 more
openalex   +3 more sources

Effect of dural inflammatory soup application on activation and sensitization markers in the caudal trigeminal nucleus of the rat and the modulatory effects of sumatriptan and kynurenic acid

The Journal of Headache and Pain, 2021
Background The topical inflammatory soup can model the inflammation of the dura mater causing hypersensitivity and activation of the trigeminal system, a phenomenon present in migraineurs.
Eleonóra Spekker, Klaudia Flóra Laborc, Zsuzsanna Bohár, Gábor Nagy-Grócz, Annamária Fejes-Szabó, Mónika Szűcs, László Vécsei, Árpád Párdutz   +7 more
doaj   +1 more source

“Kynurenine switch” and obesity

Бюллетень сибирской медицины, 2022
Aim. To assess the concentrations of bacterial and eukaryotic metabolites mainly involved in indole, kynurenine, and serotonin pathways of tryptophan metabolism in a cohort of patients with obesity. Materials and methods.
A. V. Shestopalov, O. P. Shatova, M. S. Karbyshev, A. M. Gaponov, N. E. Moskaleva, S. A. Appolonova, A. V. Tutelyan, V. V. Makarov, S. M. Yudin, S. A. Roumiantsev   +9 more
doaj   +1 more source