Results 11 to 20 of about 5,018,081 (294)

Effects of kynurenic acid on cardiovascular system

Journal of Education, Health and Sport, 2017
Kynurenic Acid (KYNA) is an endogenous metabolite of tryptophan (TRP) which is produced by aminotransferase KAT I and KAT II in the central nervous system and peripheral tissues. Moreover it has been shown that it can be supplied with food.
Piotr Kozłowski, Magdalena Kozłowska, Karolina Kozłowska   +2 more
doaj   +4 more sources

Cytotoxic Effects of Kynurenic Acid and Quinaldic Acid in Hepatocellular Carcinoma (HepG2) Cell Line [PDF]

Proceedings, 2017
Kynurenic acid (KYNA), tryptophan metabolite synthesized in the kynurenine pathway, is present in human body fluids as well as in variety of foods, herbal medicines and honeybee derived foodstuffs.
Pınar Atalay Dündar, N. Nalan İmamoğlu   +1 more
doaj   +2 more sources

Synthesis of New C-3 Substituted Kynurenic Acid Derivatives

Molecules, 2020
The application of kynurenic acid (KYNA) as an electron-rich aromatic system in the modified Mannich reaction has been examined. The extension possibility of the reaction was tested by using amines occurring in a number of bioactive products, such as ...
Bálint Lőrinczi, Antal Csámpai, Ferenc Fülöp, István Szatmári   +3 more
doaj   +2 more sources

Kynurenic acid and cancer: facts and controversies [PDF]

Cellular and Molecular Life Sciences, 2019
Kynurenic acid (KYNA) is an endogenous tryptophan metabolite exerting neuroprotective and anticonvulsant properties in the brain. However, its importance on the periphery is still not fully elucidated.
K. Walczak, Artur Wnorowski, W. Turski, T. Plech   +3 more
semanticscholar   +4 more sources

Determination of Bioactive Compound Kynurenic Acid in Linum usitatissimum L. [PDF]

Molecules
Kynurenic acid (KYNA) is a bioactive compound exhibiting multiple actions and positive effects on human health due to its antioxidant, anti-inflammatory and neuroprotective properties.
Magdalena Wróbel-Kwiatkowska, Waldemar Turski, Grażyna Silska, Magdalena Rakicka-Pustułka, Lucyna Dymińska, Waldemar Rymowicz   +5 more
doaj   +2 more sources

The Metabolism of Kynurenic Acid

Journal of Biological Chemistry, 1961
Kengo Horibata, Hiroshi Taniuchi, Minoru Tashiro, Sigeru Kuno, Osamu Hayaishi   +4 more
openalex   +4 more sources

The Metabolism of Quinaldic Acid, Kynurenic Acid, and Xanthurenic Acid in the Rabbit

Journal of Biological Chemistry, 1962
Masako Kaihara, J. M. Price
openalex   +3 more sources

Reducing brain kynurenic acid synthesis precludes kynurenine-induced sleep disturbances. [PDF]

J Sleep Res, 2023
Rentschler KM, Milosavljevic S, Baratta AM, Wright CJ, Piroli MV, Tentor Z, Valafar H, O'Reilly C, Pocivavsek A.   +8 more
europepmc   +3 more sources

Kynurenic acid inhibits macrophage pyroptosis by suppressing ROS production via activation of the NRF2 pathway. [PDF]

Mol Med Rep, 2023
Gao Y, Guo X, Zhou Y, Du J, Lu C, Zhang L, Sun S, Wang S, Li Y.   +8 more
europepmc   +3 more sources

Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer's disease

Alzheimer's & Dementia, 2023
The kynurenine pathway's (KP) malfunction is closely related to Alzheimer's disease (AD), for antagonistic kynurenic acid (KA) and agonistic quinolinic acid act on the N‐methyl‐D‐aspartate receptor, a possible therapeutic target in treating AD.
Anne-Brita Knapskog, Mari Aksnes, T. H. Edwin, Per Magne Ueland, A. Ulvik, Evandro Fei Fang, R. Eldholm, N. Halaas, I. Saltvedt, Lasse M. Giil, L. Watne   +10 more
semanticscholar   +1 more source