Results 21 to 30 of about 5,018,081 (294)

Memory Enhancement with Kynurenic Acid and Its Mechanisms in Neurotransmission

Biomedicines, 2022
Kynurenic acid (KYNA) is an endogenous tryptophan (Trp) metabolite known to possess neuroprotective property. KYNA plays critical roles in nociception, neurodegeneration, and neuroinflammation.
Diána Martos, Bernadett Tuka, Masaru Tanaka, L. Vécsei, G. Telegdy   +4 more
semanticscholar   +1 more source

Differential Effects of Hypothermia and SZR72 on Cerebral Kynurenine and Kynurenic Acid in a Piglet Model of Hypoxic-Ischemic Encephalopathy. [PDF]

Int J Mol Sci, 2023
Domoki F, Tóth-Szűki V, Kovács V, Remzső G, Körmöczi T, Vécsei L, Berkecz R.   +6 more
europepmc   +3 more sources

Kynurenic Acid Acts as a Signaling Molecule Regulating Energy Expenditure and Is Closely Associated With Metabolic Diseases

Frontiers in Endocrinology, 2022
Kynurenic acid (KYNA) is an important bio-active product of tryptophan metabolism. In addition to its well-known neuroprotective effects on mental health disorders, it has been proposed as a bio-marker for such metabolic diseases as atherosclerosis and ...
Delong Zhen, Junjun Liu, Xu Dong Zhang, Zehua Song   +3 more
semanticscholar   +1 more source

Activation of BDNF-TrkB Signaling in Specific Structures of the Sheep Brain by Kynurenic Acid. [PDF]

Cells
Roszkowicz-Ostrowska K, Młotkowska P, Marciniak E, Szlis M, Barszcz M, Misztal T.   +5 more
europepmc   +2 more sources

Kynurenic acid in neurodegenerative disorders—unique neuroprotection or double‐edged sword?

CNS Neuroscience & Therapeutics, 2021
The family of kynurenine pathway (KP) metabolites includes compounds produced along two arms of the path and acting in clearly opposite ways. The equilibrium between neurotoxic kynurenines, such as 3‐hydroxykynurenine (3‐HK) or quinolinic acid (QUIN ...
A. Ostapiuk, E. Urbanska
semanticscholar   +1 more source

Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome

Frontiers in Endocrinology, 2022
BackgroundWomen with polycystic ovary syndrome (PCOS) suffer from dysfunctional metabolism and studies have reported increased levels of tryptophan in patients with PCOS.
Siyu Wang, Siyu Wang, Siyu Wang, Liangshan Mu, Liangshan Mu, Chunmei Zhang, Chunmei Zhang, Xiaoyu Long, Xiaoyu Long, Yurong Zhang, Yurong Zhang, Yurong Zhang, Rong Li, Rong Li, Rong Li, Rong Li, Yue Zhao, Yue Zhao, Yue Zhao, Yue Zhao, Yue Zhao, Jie Qiao, Jie Qiao, Jie Qiao, Jie Qiao, Jie Qiao   +25 more
doaj   +1 more source

Natural Molecules and Neuroprotection: Kynurenic Acid, Pantethine and α-Lipoic Acid

International Journal of Molecular Sciences, 2021
The incidence of neurodegenerative diseases has increased greatly worldwide due to the rise in life expectancy. In spite of notable development in the understanding of these disorders, there has been limited success in the development of neuroprotective ...
F. Tóth, E. Cseh, L. Vécsei
semanticscholar   +1 more source

Kynurenic acid may underlie sex-specific immune responses to COVID-19

Science Signaling, 2021
Compared to females, male COVID-19 patients have more kynurenic acid, which may underlie their poorer immune response. Sex-specific metabolism and COVID-19 Males and females have different immune responses to SARS-CoV-2 infection, with male sex being a ...
Yuping Cai, Daniel J. Kim, Takehiro Takahashi, David I. Broadhurst, Hong Yan, Shuangge Ma, N. Rattray, A. Casanovas-Massana, Benjamin Israelow, J. Klein, C. Lucas, Tianyang Mao, A. Moore, M. C. Muenker, Ji-Eun Oh, Julio Silva, P. Wong, A. Ko, S. Khan, A. Iwasaki, C. Johnson   +20 more
semanticscholar   +1 more source

Analog of Kynurenic Acid Decreases Tau Pathology by Modulating Astrogliosis in Rat Model for Tauopathy

bioRxiv, 2022
Background and purpose Kynurenines have immunomodulatory and neuroactive properties and can influence the central nervous system. Previous studies showed the involvement of the kynurenines in the pathogenesis and progression of neurodegenerative disease.
P. Majerová, D. Olešová, Greta Golisova, Martina Buralova, A. Michalicová, Jozef Vegh, J. Piešťanský, M. Bhide, J. Hanes, A. Kováč   +9 more
semanticscholar   +1 more source

Kynurenic Acid and Its Synthetic Derivatives Protect Against Sepsis-Associated Neutrophil Activation and Brain Mitochondrial Dysfunction in Rats

Frontiers in Immunology, 2021
Background and Aims The systemic host response in sepsis is frequently accompanied by central nervous system (CNS) dysfunction. Evidence suggests that excessive formation of neutrophil extracellular traps (NETs) can increase the permeability of the blood–
M. Poles, Anna Nászai, L. Gulácsi, B. Czakó, K. Gál, R. Glenz, Dishana Dookhun, Attila Rutai, S. Tallósy, A. Szabó, Bálint Lőrinczi, I. Szatmári, F. Fülöp, L. Vécsei, M. Boros, L. Juhász, J. Kaszaki   +16 more
semanticscholar   +1 more source