Results 31 to 40 of about 5,018,081 (294)

Peripheral N-methyl-d-aspartate receptor activation contributes to monosodium glutamate-induced headache but not nausea behaviours in rats

Scientific Reports, 2022
Monosodium glutamate induces behaviors thought to reflect headache and nausea in rats. We explored the effects of the N-methyl-d-aspartate receptor antagonist (2R)-amino-5-phosphonovaleric acid, the inotropic glutamate receptor antagonist kynurenic acid,
Tarique Benbow, Felisha Teja, Afrooz Sheikhi, Fernando G. Exposto, Peter Svensson, Brian E. Cairns   +5 more
doaj   +1 more source

The Kynurenine Pathway is Differentially Activated in Children with Lyme Disease and Tick-Borne Encephalitis

Microorganisms, 2021
In children, tick-borne encephalitis and neuroborreliosis are common infections affecting the central nervous system. As inflammatory pathways including cytokine expression are activated in these children and appear to be of importance for outcome, we ...
Ronny Wickström, Åsa Fowler, Michel Goiny, Vincent Millischer, Sofia Ygberg, Lilly Schwieler   +5 more
doaj   +1 more source

Kynurenic Acid Electrochemical Immunosensor: Blood-Based Diagnosis of Alzheimer’s Disease

Biosensors, 2021
Alzheimer’s disease (AD) is a neurodegenerative disorder, characterized by a functional deterioration of the brain. Currently, there are selected biomarkers for its diagnosis in cerebrospinal fluid.
José Marrugo-Ramírez, M. Rodríguez-Núñez, M-Pilar Marco, M. Mir, J. Samitier   +4 more
semanticscholar   +1 more source

“Kynurenine switch” and obesity

Бюллетень сибирской медицины, 2022
Aim. To assess the concentrations of bacterial and eukaryotic metabolites mainly involved in indole, kynurenine, and serotonin pathways of tryptophan metabolism in a cohort of patients with obesity. Materials and methods.
A. V. Shestopalov, O. P. Shatova, M. S. Karbyshev, A. M. Gaponov, N. E. Moskaleva, S. A. Appolonova, A. V. Tutelyan, V. V. Makarov, S. M. Yudin, S. A. Roumiantsev   +9 more
doaj   +1 more source

Endogenous Plasma Kynurenic Acid in Human: A Newly Discovered Biomarker for Drug-Drug Interactions Involving Organic Anion Transporter 1 and 3 Inhibition

Drug Metabolism And Disposition, 2021
As an expansion investigation of drug-drug interaction (DDI) from previous clinical trials, additional plasma endogenous metabolites were quantitated in the same subjects to further identify the potential biomarkers of organic anion transporter (OAT) 1/3
Jennifer Tang, Hong Shen, Xiaofeng Zhao, Vinay K. Holenarsipur, T. Mariappan, Yueping Zhang, Erika Panfen, Jim Zheng, W. Humphreys, Yurong Lai   +9 more
semanticscholar   +1 more source

Untargeted metabolomic profiling of sepsis-induced cardiac dysfunction

Frontiers in Endocrinology, 2023
ObjectiveSepsis is a life-threatening condition secondary to infection that evolves into a dysregulated host response and is associated with acute organ dysfunction.
Yan Cao, Yan Cao, Zhengyu Liu, Zhengyu Liu, Wenfeng Ma, Chen Fang, Yanfang Pei, Yingxia Jing, Jie Huang, Xiaotong Han, Xiaotong Han, Weiwei Xiao   +11 more
doaj   +1 more source

The kynurenine pathway of tryptophan catabolism and schizophrenia [PDF]

Medicinski Podmladak, 2023
The development of new therapeutic options focused on the recovery of patients with schizophrenia is primarily conditioned by elucidating the biological underpinnings of the disorder.
Marković Miloš, Nikolić Tatjana, Totić-Poznanović Sanja   +2 more
doaj   +1 more source

Reactions of kynurenic acid with hypobromous acid and hypochlorous acid

Journal of Clinical Biochemistry and Nutrition, 2021
Kynurenic acid, a tryptophan metabolite, acts as antagonist or agonist of several receptors. Hypobromous acid (HOBr) and hypochlorous acid (HOCl) are generated by eosinophils and neutrophils. At inflammation sites, kynurenic acid may encounter HOBr and HOCl to generate products.
Toshinori Suzuki, Kosumo Fukuhara, Hiroyuki Morishita   +2 more
openaire   +4 more sources

Maternal Tryptophan Catabolites and Insulin Resistance Parameters in Preeclampsia

Biomolecules, 2023
Preeclampsia (PE) is a pregnancy-related disorder characterized by high blood pressure and proteinuria in the third trimester. The disease is associated with many metabolic and biochemical changes.
Zainab Abdulameer Jasim, Hussein Kadhem Al-Hakeim, Samaneh Zolghadri, Agata Stanek   +3 more
doaj   +1 more source

The Mechanism of the Neuroprotective Effect of Kynurenic Acid in the Experimental Model of Neonatal Hypoxia–Ischemia: The Link to Oxidative Stress

Antioxidants, 2021
The over-activation of NMDA receptors and oxidative stress are important components of neonatal hypoxia–ischemia (HI). Kynurenic acid (KYNA) acts as an NMDA receptor antagonist and is known as a reactive oxygen species (ROS) scavenger, which makes it a ...
Ewelina Bratek-Gerej, A. Ziembowicz, J. Godlewski, E. Salińska   +3 more
semanticscholar   +1 more source