Results 71 to 80 of about 5,018,081 (294)

Measurement of kynurenine pathway metabolites by tandem mass spectrometry

Journal of Mass Spectrometry and Advances in the Clinical Lab, 2023
Objectives: Recent studies have shown that derangements in kynurenine pathway metabolite levels are associated with various pathologies such as neurodegenerative diseases, schizophrenia, depression, bipolar disorder, rheumatoid arthritis, and cancer ...
Sedat Abusoglu, Duygu Eryavuz Onmaz, Gulsum Abusoglu, Fatma Humeyra Yerlikaya, Ali Unlu   +4 more
doaj  

Effects of ethylenediamine – a putative GABA-releasing agent – on rat hippocampal slices and neocortical activity in vivo [PDF]

, 2010
The simple diamine diaminoethane (ethylenediamine, EDA) has been shown to activate GABA receptors in the central and peripheral nervous systems, partly by a direct action and partly by releasing endogenous GABA.
Addae, J.I., Lui, C., Stone, T.W.
core   +1 more source

Clinical relevance of depressed kynurenine pathway in episodic migraine patients: potential prognostic markers in the peripheral plasma during the interictal period

The Journal of Headache and Pain, 2021
Background Altered glutamatergic neurotransmission and neuropeptide levels play a central role in migraine pathomechanism. Previously, we confirmed that kynurenic acid, an endogenous glutamatergic antagonist, was able to decrease the expression of ...
Bernadett Tuka, Aliz Nyári, Edina Katalin Cseh, Tamás Körtési, Dániel Veréb, Ferenc Tömösi, Gábor Kecskeméti, Tamás Janáky, János Tajti, László Vécsei   +9 more
doaj   +1 more source

Obesity and cancer: existing and new hypotheses for a causal connection [PDF]

, 2018
Existing explanations of obesity-associated cancer emphasise direct mutagenic effects of dietary components or hormonal imbalance. Some of these hypotheses are reviewed briefly, but recent evidence suggests a major role for chronic inflammation in cancer
Darlington, L. Gail, McPherson, Megan, Stone, Trevor W.   +2 more
core   +2 more sources

Time of Day-Dependent Alterations in Hippocampal Kynurenic Acid, Glutamate, and GABA in Adult Rats Exposed to Elevated Kynurenic Acid During Neurodevelopment

Frontiers in Psychiatry, 2021
Hypofunction of glutamatergic signaling is causally linked to neurodevelopmental disorders, including psychotic disorders like schizophrenia and bipolar disorder.
Courtney J. Wright, Katherine M. Rentschler, Nathan T. J. Wagner, Ashley M. Lewis, Sarah Beggiato, Ana Pocivavsek   +5 more
doaj   +1 more source

Nicotinic α7 acetylcholine receptor-mediated currents are not modulated by the tryptophan metabolite kynurenic acid in adult hippocampal interneurons [PDF]

, 2011
The  tryptophan  metabolite,  kynurenic  acid (KYNA),  is  classically  known  to  be  an antagonist  of ionotropic glutamate receptors.
Andrew L. Varnell, Donald C. Cooper, Kevin J. Staley, Peter Dobelis   +3 more
core   +3 more sources

Memantine and Kynurenic Acid: Current Neuropharmacological Aspects [PDF]

Current Neuropharmacology, 2016
Glutamatergic neurotransmission, of special importance in the human brain, is implicated in key brain functions such as synaptic plasticity and memory. The excessive activation of N-methyl- D-aspartate (NMDA) receptors may result in excitotoxic neuronal damage; this process has been implicated in the pathomechanism of different neurodegenerative ...
Majláth Zsófia, Török Nóra, Toldi József, Vécsei László   +3 more
openaire   +4 more sources

Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis [PDF]

, 2009
Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasites <i>Trypanosoma brucei rhodesiense</i> or <i>Trypanosoma brucei gambiense</i>, and is a major cause of systemic and neurological disability ...
Adams, B. Bradley, Clark, Eastman, Eastman, Giles, Gonzalez, Guidetti, Hirumi, J. Rodgers, Jennings, Jennings, Jhamandas, Kamleh, Kennedy, Kennedy, Kennedy, Kennedy, M. P. Barrett, Moffett, Okuda, Okuda, P. G. E. Kennedy, Pepin, Perkins, Pfefferkorn, P  pin, R  z, Sanni, Schroten, Schwarcz, Smith, Sternberg, Stone, Stone, Stone, T. W. Stone, Vincendeau   +37 more
core   +2 more sources

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing

Advanced Science, EarlyView.
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang, Yuehui Xi, Qiaojun Fang, Sai Shi, Fei Wang, Fuyu Xian, Zhongyang Zhang, Yuxin Yang, Xishuo Jin, Xiaomin Wang, Chen Cao, Hailin Zhang, Nikita Gamper, Zhigang Xu, Haitao Shen, Ping Lv   +15 more
wiley   +1 more source

Mesenchymal Stromal Cell Secretome and Its Key Bioactive Metabolites Induce Long‐Term Neuroprotection After Traumatic Brain Injury in Mice

Advanced Science, EarlyView.
Pischiutta F and coworkers identify prostaglandins and kynurenine as key mediators of the mesenchymal stromal cells‐derived secretome's neuroprotective effects. A synthetic cocktail composed of these factors promotes long‐term functional recovery, reduces brain structural damage, and modulates neuroinflammation after traumatic brain injury, supporting ...
Francesca Pischiutta, Francesca Tribuzio, Marta Magatti, Giulia De Simone, Federico Moro, Giovanni Nattino, Fabiola Signorini, Luther Loose, Enrico Caruso, Costanza Bertani, Edoardo Mazzone, Rosaria Pascente, Edoardo Micotti, Antonietta Rosa Silini, Fabrizio Ortolano, Maria Chiara Trolese, Marco Bolis, Luca Guarrera, Martina Bruna Violatto, Paolo Bigini, Cristina Banfi, Roberta Pastorelli, Ornella Parolini, Laura Brunelli, Elisa R Zanier   +24 more
wiley   +1 more source