Results 121 to 130 of about 5,526 (234)

Histone Changes as a Response to Lactic Acid Selection in Cells of Austrofundulus limnaeus [PDF]

The killifish Austrofundulus limnaeus is an extremophile native to small temporary ponds of Venezuela. Normal embryonic development of A. limnaeus is segmented into up to three stages of metabolic depression (diapause), and both developing and diapausing
Hughes, Chelsea, Podrabsky, Jason, Tran, Lori   +2 more
core   +1 more source

Exploring lactylation and cancer biology: insights from pathogenesis to clinical applications [PDF]

As a byproduct of glycolysis, lactate functions as a signaling molecule, a substrate for energy metabolism, and a regulator of the tumor microenvironment (TME).
Jiannan Li, Qianchuang Sun, Zixuan Gou
core   +1 more source

Multi-omics reveals lactylation-driven regulatory mechanisms promoting tumor progression in oral squamous cell carcinoma

Genome Biology
Background Lactylation, a post-translational modification, is increasingly recognized for its role in cancer progression. This study investigates its prevalence and impact in oral squamous cell carcinoma (OSCC). Results Immunohistochemical staining of 81
Fengyang Jing, Lijing Zhu, Jianyun Zhang, Xuan Zhou, Jiaying Bai, Xuefen Li, Heyu Zhang, Tiejun Li   +7 more
doaj   +1 more source

Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity

Advanced Science, Volume 13, Issue 16, 18 March 2026.
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng, Zhe Lei, Zhehao Zhang, Zhiyue Su, Chonghai Zhang, Huan Yang, Shu Liu, Mengyuan Hu, Yuhong Wang, Lingchuan Guo, Lin Hu, Kai Yang   +11 more
wiley   +1 more source

Lactate‐induced metabolic reprogramming of TAMs impairs antigen presentation capacity via C/EBPα–CD74 axis in oral squamous cell carcinoma

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
• CD74hi TAMs correlate with favourable prognosis in OSCC. • Lactate reprograms TAMs metabolism and increases mitochondrial respiration. • C/EBPα acetylation suppresses CD74 and impairs antigen presentation. • Restoring CD74 enhances T‐cell activation and limits OSCC progression.
Mengyao Wang, Mengqi Wang, Zizhen Gong, Fanrui Zeng, Zihui Ni, Rundong Zhai, Weiwen Zhu, Jiayi Zhang, Laikui Liu   +8 more
wiley   +1 more source

Integrated analysis of single-cell RNA-seq and spatial transcriptomics to identify the lactylation-related protein TUBB2A as a potential biomarker for glioblastoma in cancer cells by machine learning

Frontiers in Immunology
BackgroundAn increasing number of studies have revealed a link between lactylation and tumor initiation and progression. However, the specific impact of lactylation on inter-patient heterogeneity and recurrence in glioblastoma (GBM) remains to be further
Yifan Xu, Chonghui Zhang, Jinpeng Wu, Pin Guo, Nan Jiang, Chao Wang, Yugong Feng   +6 more
doaj   +1 more source

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

Tumor glucose reprogramming suppresses cuproptosis: A review [PDF]

Cuproptosis is a copper-dependent form of regulated cell death that begins when ferredoxin 1 (FDX1) reduces Cu²⁺ to Cu¹⁺, allowing the ion to bind lipoylated enzymes of the tricarboxylic-acid (TCA) cycle, drive protein aggregation, dismantle iron–sulphur
Chen, Jing-Song, Ding, Yi-Hang, Song, Xiao-Hang   +2 more
core   +2 more sources

The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities

MedComm, Volume 7, Issue 3, March 2026.
Diverse diseases converge on NLRP3. We depict a discovery‐to‐clinic track: high‐throughput/phenotypic screens, structure‐guided design, and modality innovation (allosteric inhibitors, interface blockers, degraders) deliver third‐generation, disease‐tailored NLRP3 control.
Chan Zou, Shilong Jiang, Hui Li, Kai Zhao, Dongshen Cao, Guoping Yang   +5 more
wiley   +1 more source

A lactylation modification-related prediction model for the diagnosis of ulcerative colitis based on machine learning

Frontiers in Immunology
BackgroundLactylation modification serves as a critical link between metabolic reprogramming and epigenetic regulation, playing a significant role in the progression of both malignant tumors and inflammatory diseases.
Jian Liu, Xiaoyun Kang, Yanxiang Zhou, Jiao Li   +3 more
doaj   +1 more source