Results 131 to 140 of about 5,526 (234)

Downregulating Platelet Endothelial Cell Adhesion Molecule‐1 Enhances Learning and Memory and Alleviates Hallmark Pathologies in Alzheimer's Disease

MedComm, Volume 7, Issue 3, March 2026.
CD31 upregulation in 5xFAD mice activates STAT1/Irf1 signaling, driving abnormal gene transcription, Aβ and tau accumulation, microglial activation, and neuroinflammation, leading to cognitive decline. Systemic CD31 knockdown suppresses STAT1/Irf1 activity, restores gene expression balance, reduces Aβ and tau pathologies, alleviates neuroinflammation ...
Qiuzhi Zhou, Fei Sun, Yao Zhang, Xiaojian Cao, Mengzhu Li, Haitao Yu, Tao Jiang, Shihong Li, Weixia Wang, Jiazhao Xie, Ting He, Yanchao Liu, Xiuping Liu, Ying Yang, Dan Ke, Xiao‐Chuan Wang, Enjie Liu, Jian‐Zhi Wang   +17 more
wiley   +1 more source

Insights into recent findings and therapeutic potential of nonhistone lactylation in cancer [PDF]

Lactylation, a recently identified post-translational modification, has become a crucial regulatory mechanism beyond its conventional metabolic role. Unlike histone lactylation, which regulates gene expression, nonhistone lactylation directly acts on ...
Jing Jia, Minbin Chen, Na Liu, Xiaoren Zhu, Xiaoren Zhu   +4 more
core   +1 more source

Characterization of lactylation-based phenotypes and molecular biomarkers in sepsis-associated acute respiratory distress syndrome

Scientific Reports
Sepsis-associated acute respiratory distress syndrome (ARDS) is a heterogeneous disease with high morbidity and mortality. Lactylation plays a crucial role in sepsis and sepsis-induced lung injury.
Yiheng Wang, An Wei, Zixuan Su, Yunyi Shi, Xinqiu Li, Lixian He   +5 more
doaj   +1 more source

Lactylation in CNS disorders: mechanisms, cellular function, and disease relevance [PDF]

Lactate, as a metabolic product or energy substrate, participates in various neurological processes within the physiological and pathological frameworks of the central nervous system (CNS).
Jiaxin Tian, Jingyu Dong, Jinpeng Zhou, Ruidan Zhang, Sijia Hao, Tongyu Zhang, Yang Tian, Yiyan Chen   +7 more
core   +1 more source

Single-cell and spatial transcriptomics reveal lactylation-associated tumor cell clusters and define a prognostic risk model in glioblastoma

BMC Cancer
Background Glioblastoma (GBM) is the most aggressive adult brain tumor, marked by intratumoral heterogeneity and therapy resistance. Metabolic reprogramming through histone lactylation has been linked to tumor progression and immune suppression. However,
Rui Han, Guangfan Chi, Dongjie Sun, Ziran Xu, Liangfu Zhou, Kan Xu   +5 more
doaj   +1 more source

New insights into the roles of lactylation in cancer

Frontiers in Pharmacology
Lactylation, a novel discovered posttranslational modification, is a vital component of lactate function and is prevalent in a wide range of cells, interacting with both histone and non-histone proteins.
Yajun Zhu, Yajun Zhu, Wenhui Liu, Wenhui Liu, Zhiying Luo, Zhiying Luo, Feiyan Xiao, Bao Sun, Bao Sun   +8 more
doaj   +1 more source

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, Volume 2, Issue 1, Page 4-21, March 2026.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

Microglia lactylation in relation to central nervous system diseases [PDF]

The development of neurodegenerative diseases is closely related to the disruption of central nervous system homeostasis. Microglia, as innate immune cells, play important roles in the maintenance of central nervous system homeostasis, injury response ...
Dong, Jianhong, Fan, Ziwei, Jia, Mengxian, Mo, Nan, Tong, Lily, Wang, Ying, Yang, Hui, Yue, Juanqing   +7 more
core   +1 more source

Ubiquitous protein lactylation in health and diseases

Cellular & Molecular Biology Letters
AbstractFor decades, lactate has been considered a byproduct of glycolysis. The lactate shuttle hypothesis shifted the lactate paradigm, demonstrating that lactate not only plays important roles in cellular metabolism but also cellular communications, which can transcend compartment barriers and can occur within and among different cells, tissues and ...
Junyong Wang, Ziyi Wang, Qixu Wang, Xiao Li, Yaping Guo   +4 more
openaire   +3 more sources

Noninvasive 11.7‐T Magnetic Resonance Spectroscopy and Imaging Reveals Retinal Metabolic Alterations Induced by Blue Light Exposure

NMR in Biomedicine, Volume 39, Issue 3, March 2026.
Retinal metabolic changes were analyzed using proton magnetic resonance spectroscopy (1H‐MRS), marking an initial application of this non‐invasive method on living eyes. Key metabolites were identified within the retinal region of adult rats. The observed changes following intense blue light exposure were predominantly attributable to the retina, as it
Lacramioara Samoila, Alexandru Farcasanu, Simion Simon, Ede Bodoki, Ovidiu Samoila, Oliviu Vostinaru, Elena Dinte, Andreea Elena Bodoki, Dan Iudean, Calin Muresan, Simona Clichici   +10 more
wiley   +1 more source