Results 31 to 40 of about 1,866,196 (278)

A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

bioRxiv, 2021
Sirtuin 6 (SIRT6) is a deacylase and mono-ADP ribosyl transferase (mADPr) enzyme involved in multiple cellular pathways implicated in the regulation of aging and metabolism.
M. Simon, Jiping Yang, Jonathan Gigas, E. Earley, Tory M. Schaff, Lei Zhang, Maria Zagorulya, G. Tombline, Michael Gilbert, Samantha L. Yuen, A. Pope, M. V. Meter, S. Emmrich, Jeehae Han, Seungjin Ryu, Archana Tare, Yizhou Zhu, Adam D. Hudgins, G. Atzmon, N. Barzilai, A. Wolfe, Kelsey Moody, B. Garcia, David D. Thomas, P. Robbins, J. Vijg, A. Seluanov, Y. Suh, V. Gorbunova   +28 more
semanticscholar   +1 more source

Filament assembly of the C. elegans lamin in the absence of helix 1A

Nucleus, 2022
Lamins are the major constituent of the nuclear lamina, a protein meshwork underlying the inner nuclear membrane. Nuclear lamins are type V intermediate filaments that assemble into ~3.5 nm thick filaments.
Rebecca de Leeuw, Rafael Kronenberg-Tenga, Matthias Eibauer, Ohad Medalia   +3 more
doaj   +1 more source

Repo-Man/protein phosphatase 1 SUMOylation mediates binding to lamin A and serine 22 dephosphorylation

Open Biology, 2022
Lamin A phosphorylation/de-phosphorylation is an important process during cells division as it allows for nuclear envelope (NE) disassembly at mitotic entry and its re-assembly during mitotic exit.
Florentin Huguet, Ezgi Gokhan, Helen A. Foster, Hasnat A. Amin, Paola Vagnarelli   +4 more
doaj   +1 more source

Expression of Drosophila lamin C is developmentally regulated: analogies with vertebrate A-type lamins [PDF]

Journal of Cell Science, 1995
ABSTRACT Vertebrate nuclear lamins form a multigene family with developmentally controlled expression. In contrast, invertebrates have long been thought to contain only a single lamin, which in Drosophila is the well-characterized lamin Dm0.
Riemer, D., Stuurman, N., Berrios, M., Hunter, C., Fisher, P., Weber, K.   +5 more
openaire   +3 more sources

Laminopathies: what can humans learn from fruit flies

Cellular & Molecular Biology Letters, 2018
Lamin proteins are type V intermediate filament proteins (IFs) located inside the cell nucleus. They are evolutionarily conserved and have similar domain organization and properties to cytoplasmic IFs. Lamins provide a skeletal network for chromatin, the
Marta Pałka, Aleksandra Tomczak, Katarzyna Grabowska, Magdalena Machowska, Katarzyna Piekarowicz, Dorota Rzepecka, Ryszard Rzepecki   +6 more
doaj   +1 more source

The different function of single phosphorylation sites of Drosophila melanogaster lamin Dm and lamin C.

PLoS ONE, 2012
Lamins' functions are regulated by phosphorylation at specific sites but our understanding of the role of such modifications is practically limited to the function of cdc 2 (cdk1) kinase sites in depolymerization of the nuclear lamina during mitosis.
Magdalena Zaremba-Czogalla, Katarzyna Piekarowicz, Katarzyna Wachowicz, Katarzyna Kozioł, Magda Dubińska-Magiera, Ryszard Rzepecki   +5 more
doaj   +1 more source

Cell‐type‐specific role of lamin‐B1 in thymus development and its inflammation‐driven reduction in thymus aging

Aging Cell, 2019
Cellular architectural proteins often participate in organ development and maintenance. Although functional decay of some of these proteins during aging is known, the cell‐type‐specific developmental role and the cause and consequence of their subsequent
S. Yue, Xiaobin Zheng, Yixian Zheng
semanticscholar   +1 more source

Lamin A/C phosphorylation at serine 22 is a conserved heat shock response to regulate nuclear adaptation during stress

bioRxiv, 2022
The heat shock (HS) response is crucial for cell survival in harmful environments. Nuclear lamin A/C, encoded by LMNA gene, has been shown to contribute towards altered gene expression during heat shock, but the underlying mechanisms are poorly ...
Laura Virtanen, E. Holm, Mona Halme, Gun West, Fanny Lindholm, Josef Gullmets, J. Irjala, T. Heliö, A. Padzik, Annika Meinander, J. Eriksson, P. Taimen   +11 more
semanticscholar   +1 more source

Lamin A/C is a risk biomarker in colorectal cancer.

PLoS ONE, 2008
BackgroundA-type lamins are type V intermediate filament proteins encoded by the gene LMNA. Mutations in LMNA give rise to diverse degenerative diseases related to premature ageing. A-type lamins also influence the activity of the Retinoblastoma protein (
Naomi D Willis, Thomas R Cox, Syed F Rahman-Casañs, Kim Smits, Stefan A Przyborski, Piet van den Brandt, Manon van Engeland, Matty Weijenberg, Robert G Wilson, Adriaan de Bruïne, Christopher J Hutchison   +10 more
doaj   +1 more source

Protein Kinase C Alpha Cellular Distribution, Activity, and Proximity with Lamin A/C in Striated Muscle Laminopathies

Cells, 2020
Striated muscle laminopathies are cardiac and skeletal muscle conditions caused by mutations in the lamin A/C gene (LMNA). LMNA codes for the A-type lamins, which are nuclear intermediate filaments that maintain the nuclear structure and nuclear ...
Hannah A. Nicolas, Anne T. Bertrand, Sarah Labib, Musfira Mohamed-Uvaize, Pierrette M. Bolongo, Wen Yu Wu, Zofia T. Bilińska, Gisèle Bonne, Marie-Andrée Akimenko, Frédérique Tesson   +9 more
doaj   +1 more source