Results 61 to 70 of about 1,866,196 (278)

Nurturing the genome [PDF]

Nucleus, 2010
A-type lamins provide a scaffold for tethering chromatin and protein complexes regulating nuclear structure and function. Interest in lamins increased after mutations in the LMNA gene were found to be associated with a variety of human disorders termed laminopathies. These include muscular dystrophy, cardiomyopathy, lipodystrophy, peripheral neuropathy
Gonzalez-Suarez, Ignacio, Gonzalo, Susana   +1 more
openaire   +3 more sources

Lamin A, Chromatin and FPLD2: Not Just a Peripheral Ménage-à-Trois

Frontiers in Cell and Developmental Biology, 2018
At the nuclear periphery, the genome is anchored to A- and B-type nuclear lamins in the form of heterochromatic lamina-associated domains. A-type lamins also associate with chromatin in the nuclear interior, away from the peripheral nuclear lamina.
Nolwenn Briand, Nolwenn Briand, Inswasti Cahyani, Julia Madsen-Østerbye, Jonas Paulsen, Torunn Rønningen, Anita L. Sørensen, Philippe Collas, Philippe Collas   +8 more
doaj   +1 more source

Deletion of MLIP (Muscle-enriched A-type Lamin-interacting Protein) Leads to Cardiac Hyperactivation of Akt/Mammalian Target of Rapamycin (mTOR) and Impaired Cardiac Adaptation*

Journal of Biological Chemistry, 2015
Background: MLIP (muscle enriched A-type lamin-interacting protein) is a unique protein of yet unknown function. Results: MLIP impacts cardiac activity of Akt/mTOR pathways and is associated with and required for precocious cardiac adaptation to stress ...
Marie-Elodie Cattin, Jessica J Wang, Jonathan J. Weldrick, Cassandra L Roeske, E. Mak, S. Thorn, J. DaSilva, Yibin Wang, A. Lusis, P. Burgon   +9 more
semanticscholar   +1 more source

Reduced Lamin A/C Does Not Facilitate Cancer Cell Transendothelial Migration but Compromises Lung Metastasis

Cancers, 2021
Simple Summary The nucleus is the largest and stiffest organelle of tumor cells. Cancer metastasis depends on the ability of cancer cells circulating in the blood to exit blood vessels and survive in target organs.
Francesco Roncato, O. Regev, Sara W. Feigelson, Sandeep Kumar Yadav, L. Kaczmarczyk, Nehora Levi, Diana Drago-Garcia, Samuel Ovadia, Marina Kizner, Y. Addadi, João C. Sabino, Yossi Ovadya, Sérgio F. de Almeida, E. Feldmesser, G. Gerlitz, R. Alon   +15 more
semanticscholar   +1 more source

A Rare Mutation in LMNB2 Associated with Lipodystrophy Drives Premature Cell Senescence

Cells, 2021
Many proteins are causative for inherited partial lipodystrophies, including lamins, the essential constituents of the nuclear envelope scaffold called the lamina.
Alice-Anaïs Varlet, Camille Desgrouas, Cécile Jebane, Nathalie Bonello-Palot, Patrice Bourgeois, Nicolas Levy, Emmanuèle Helfer, Noémie Dubois, René Valero, Catherine Badens, Sophie Beliard   +10 more
doaj   +1 more source

Nuclear lamin A in rotator cuff tear margin tenocytes: an antiapoptotic and cell mechanostat factor

Journal of Orthopaedic Surgery and Research, 2021
Background The network of intermediate filament proteins underlying the inner nuclear membrane forms the nuclear lamin. A- and B-type lamins are the major components of the nuclear lamina. Lamins function in many nuclear activities.
Stefano Gumina, Barbara Peruzzi, Martina Leopizzi, Natale Porta, Valeria Di Maio, Carlo Della Rocca, Vittorio Candela   +6 more
doaj   +1 more source

Insulin-response epigenetic activation of Egr-1 and JunB genes at the nuclear periphery by A-type lamin-associated pY19-Caveolin-2 in the inner nuclear membrane

Nucleic Acids Research, 2015
Insulin controls transcription to sustain its physiologic effects for the organism to adapt to environmental changes added to genetic predisposition. Nevertheless, insulin-induced transcriptional regulation by epigenetic factors and in defined nuclear ...
Kyuho Jeong, Hayeong Kwon, Jaewoong Lee, Donghwan Jang, Yunbae Pak   +4 more
semanticscholar   +1 more source

Perturbation of wild‐type lamin A metabolism results in a progeroid phenotype [PDF]

Aging Cell, 2008
SummaryMutations in the lamin A/C gene cause the rare genetic disorder Hutchinson–Gilford progeria syndrome (HGPS). The prevalent mutation results in the production of a mutant lamin A protein with an internal 50 amino acid deletion which causes a cellular aging phenotype characterized by growth defects, limited replicative lifespan, and nuclear ...
Jose, Candelario, Sivasubramaniam, Sudhakar, Sonia, Navarro, Sita, Reddy, Lucio, Comai   +4 more
openaire   +2 more sources

Voltage gain effect in a ring-type magnetoelectric laminate [PDF]

Applied Physics Letters, 2004
It has been observed that a ring-type magnetoelectric laminate composite of circumferentially magnetized magnetostrictive Tb1−xDyxFe2 and circumferentially polarized piezoelectric Pb(Zr,Ti)O3 layers has a large magnetoelectric voltage gain effect, offering potential in high-power miniature transformer applications.
Dong, Shuxiang, Li, Jiefang, Viehland, Dwight D.   +2 more
openaire   +1 more source

Perinuclear Lamin A and Nucleoplasmic Lamin B2 Characterize Two Types of Hippocampal Neurons through Alzheimer’s Disease Progression [PDF]

International Journal of Molecular Sciences, 2020
Background. Recent reports point to a nuclear origin of Alzheimer’s disease (AD). Aged postmitotic neurons try to repair their damaged DNA by entering the cell cycle. This aberrant cell cycle re-entry involves chromatin modifications where nuclear Tau and the nuclear lamin are involved.
Laura Gil, Sandra A. Niño, Erika Chi-Ahumada, Ildelfonso Rodríguez-Leyva, Carmen Guerrero, Ana Belén Rebolledo, José A. Arias, María E. Jiménez-Capdeville   +7 more
openaire   +2 more sources