Results 61 to 70 of about 129 (128)
Aging Cell, Volume 24, Issue 5, May 2025.We created an inducible system to control the expression of p16, and found that tau phosphorylation was enhanced upon p16 up‐regulation in neurons differentiated from human iPSCs. As p16 expression is increased during aging, our findings suggest a possible role of age‐associated p16 up‐regulation in Alzheimer's disease. As pathological tau tangles have
Kristopher Holloway +7 more
wiley +1 more source
Targeting CRM1 for Progeria Syndrome Therapy
Aging Cell, Volume 24, Issue 5, May 2025.Pharmacological inhibition of CRM1 mediated by selinexor, the first‐in‐class selective inhibitor of CRM1, mitigates the senescent phenotype of Hutchinson‐Gilford progeria syndrome (HGPS) patients‐derived primary fibroblasts. Treatment of HGPS fibroblasts with selinexor promotes the clearances of progerin via autophagy activation, restores the ...
Adriana Soto‐Ponce +14 more
wiley +1 more source
Circular RNA Telomerase Reverses Endothelial Senescence in Progeria
Aging Cell, EarlyView.TERT circRNA outperforms linear TERT mRNA in reversing the hallmarks of senescence. TERT circRNA more efficiently restores endothelial function and shows superior capability in enhancing mitochondrial function. ABSTRACT Telomeres shorten with each cell division, acting as a chronometer of cell age. The enzyme telomerase, primarily active in stem cells,
Weifeng Qin +6 more
wiley +1 more source
Aging Cell, EarlyView.Direct activation and rejuvenation of aged fibroblasts through the application of mechanical forces in a 3D spheroid culture model. The ERK signaling pathway was revealed as a key underlying mechanism. ABSTRACT Age‐related changes in human dermal fibroblasts (HDFs) contribute to impaired wound healing and skin aging.
Hui Liu +4 more
wiley +1 more source
Cellular Senescence Is a Central Driver of Cognitive Disparities in Aging
Aging Cell, EarlyView.The molecular underpinnings of divergent cognitive trajectories in aging remain unresolved. Using high‐resolution behavioral testing to cognitively stratify aged male mice into ‘intact’ and ‘impaired’ subgroups, we show that reactive gliosis and cellular senescence are key determinants of disparities in cognitive function with age.
Matthew P. Baier +9 more
wiley +1 more source
Aging Cell, EarlyView.Multi‐ciliated cells in the infundibulum and ampulla (INF/AMP) epithelium are vacuolated in aging. Unique cellular susceptibility of the INF/AMP epithelial population and aging‐associated decline in ovarian artery circulation, which supports the ovary and INF/AMP, contribute to this region‐specific vacuolation phenotype, as a consequence of a mildly ...
Keerthana Harwalkar +10 more
wiley +1 more source
Aging Cell, EarlyView.Expression of HIRA in embryonic melanoblasts is required for proper epigenetic programing and lineage differentiation. Although HIRA deficiency results in a mild phenotype at birth and young adulthood, the melanocytic lineage is sensitive to proliferative challenge, prone to loss of stem cells and dramatically accelerated hair greying in later life ...
Farah Jaber‐Hijazi +20 more
wiley +1 more source
Aging Cell, EarlyView.Schematic diagram illustrating the protective role of protein disulphide isomerase (PDI) against DNA damage via non‐homologous end‐joining (NHEJ), which repairs double stranded DNA breaks (DSBs). Induction of DNA damage results in the formation of γH2AX and p53‐binding protein 1 foci during NHEJ repair of DSBs.
Sina Shadfar +12 more
wiley +1 more source
Myonuclear dynamics with age and exercise: shaping up for a good time
, 2023 The Journal of Physiology, EarlyView.
Cory M. Dungan
wiley +1 more source