Results 91 to 100 of about 2,855 (207)

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

Journal of Lipid Research, 2004
24S-hydroxycholesterol is a side-chain oxidized oxysterol formed in the brain that is continuously crossing the blood-brain barrier to reach the circulation. There may be an opposite flux of 27-hydroxycholesterol, which is formed to a lower extent in the
Maura Heverin, Nenad Bogdanovic, Dieter Lütjohann, Thomas Bayer, Irina Pikuleva, Lionel Bretillon, Ulf Diczfalusy, Bengt Winblad, Ingemar Björkhem   +8 more
doaj   +1 more source

Involvement of 27-Hydroxycholesterol in Mitotane Action on Adrenocortical Carcinoma

Cells, 2020
Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Mitotane, the standard treatment for ACC, impairs adrenocortical steroid biosynthesis and cholesterol metabolism.
Antonina Germano, Daniela Rossin, Valerio Leoni, Noemi Iaia, Laura Saba, Vittoria Basile, Soraya Puglisi, Claudio Caccia, Giuseppe Poli, Fiorella Biasi, Massimo Terzolo   +10 more
doaj   +1 more source

24s-Hydroxycholesterol. Studies on regulatory mechanisms behind its formation in the brain and its potential use as a marker for neurodegeneration [PDF]

, 2010
Cholesterol 24-hydroxylase (CYP46A1) belongs to the cytochrome P450 super family and is responsible for conversion of cholesterol to the oxysterol 24S- hydroxycholesterol (24S-OHC).
Shafaati, Marjan
core  

Impacts of Vincristine and Prednisolone Chemotherapy on the Canine Gut Microbiota in Dogs Undergoing Treatment for Lymphoma

Veterinary and Comparative Oncology, Volume 23, Issue 3, Page 388-400, September 2025.
ABSTRACT Chemotherapy can have adverse gastrointestinal effects in dogs and people. The objective of this study was to assess the impact of vincristine and prednisolone/prednisone, as part of a CHOP chemotherapy [cyclophosphamide, hydroxydaunorubicin, oncovin (vincristine) and prednisolone/prednisone] protocol, on gastrointestinal dysbiosis in dogs ...
Juan Aragon, Annika M. Weber, Madison Tipton, Jennifer Thomsen, Hend Ibrahim, Kristen Weishaar, Sangeeta Rao, Jan S. Suchodolski, Jonathan Stockman, Elizabeth P. Ryan, Nora Jean Nealon   +10 more
wiley   +1 more source

Effects of pravastatin and cholestyramine on products of the mevalonate pathway in familial hypercholesterolemia.

Journal of Lipid Research, 1991
Patients with heterozygous familial hypercholesterolemia (n = 12) were treated either with pravastatin, a specific inhibitor of HMG-CoA reductase, or cholestyramine, followed by a period of combined treatment with both drugs.
PG Elmberger, A Kalén, E Lund, E Reihnér, M Eriksson, L Berglund, B Angelin, G Dallner   +7 more
doaj   +1 more source

The effect of the apolipoprotein E phenotype on plasma lipids is not influenced by environmental variability: results of a Dutch twin study [PDF]

, 1993
We tested the influence of the apolipoprotein E (apoE) polymorphism on the intrapair differences in the levels of plasma cholesterol, plasma triglycerides, low density lipoprotein-cholesterol, apoB and apoE in monozygotic (MZ) twins, and estimated ...
Boomsma, D.I., Frants, R.R., Gevers-Leuven, J.A., Havekes, L.M., Kempen, H.J.M., Knijff, P. de, Wit, E. de   +6 more
core   +2 more sources

Role for the liver X receptor agonist 22‐ketositosterol in preventing disease progression in an Alzheimer's disease mouse model

British Journal of Pharmacology, Volume 182, Issue 16, Page 3744-3766, August 2025.
Background and Purpose Liver X receptors (LXRs) are promising therapeutic targets for alleviating Alzheimer's disease (AD) symptoms. We assessed the impact of the semi‐synthetic LXR agonist 22‐ketositosterol on disease progression in an AD mouse model.
Nikita Martens, Na Zhan, Sammie C. Yam, Marcella Palumbo, Lorenzo Pontini, Frank P. J. Leijten, Leonie van Vark‐van der Zee, Gardi Voortman, Silvia Friedrichs, Albert Gerding, Maura Marinozzi, Johan W. Jonker, Folkert Kuipers, Dieter Lütjohann, Tim Vanmierlo, Monique T. Mulder   +15 more
wiley   +1 more source

Serum squalene and noncholesterol sterols before and after delivery in normal and cholestatic pregnancy

Journal of Lipid Research, 1996
Mechanisms of hyperlipidemia were studied by measurement of serum lipid concentrations and the ratios of cholesterol precursors (squalene, delta 8-cholestenol, desmosterol, and lathosterol), plant sterols (campesterol and sitosterol), and cholestanol (a ...
K Nikkilä, S Riikonen, M Lindfors, T A Miettinen   +3 more
doaj   +1 more source

RETRACTED ARTICLE: Age-dependent Increase in Desmosterol Restores DRM Formation and Membrane-related Functions in Cholesterol-free DHCR24−/− Mice [PDF]

, 2018
Cholesterol is a prominent modulator of the integrity and functional activity of physiological membranes and the most abundant sterol in the mammalian brain. DHCR24-knock-out mice lack cholesterol and accumulate desmosterol with age.
Crameri, Arames, Heppner, Frank, Kalvodova, Lucie, Kuehnle, Katrin, Kulic, Luka, Ledesma, Maria, Lütjohann, Dieter, Mohajeri, M., Nitsch, Roger, Skaanes-Brunner, Fabienne, Smith, Alicia, Thelen, Karin   +11 more
core  

The effect of lyophilised oral faecal microbial transplantation on functional outcomes in dogs with diabetes mellitus

Journal of Small Animal Practice, Volume 66, Issue 8, Page 567-581, August 2025.
Objectives We aimed to determine if oral faecal microbiota transplantation improves indices of glycaemic control, changes the faecal dysbiosis indices, alters faecal short‐chain fatty acid and bile acid profiles and increases serum glucagon‐like‐peptide 1 concentrations in diabetic dogs.
R. Brown, P. Barko, J. D. J. Ruiz Romero, D. A. Williams, A. Gochenauer, J. Nguyen‐Edquilang, J. S. Suchodolski, R. Pilla, H. Ganz, N. Lopez‐Villalobos, A. Gal   +10 more
wiley   +1 more source