Results 11 to 20 of about 2,855 (207)

Age-related changes of cholestanol and lathosterol plasma concentrations: an explorative study [PDF]

Lipids in Health and Disease, 2019
Background Cerebrotendinous xanthomatosis (CTX) and Lathosterolosis represent two treatable inherited disorders of cholesterol metabolism that are characterized by the accumulation of cholestanol and lathosterol, respectively.
Monica Gelzo, Maria Donata Di Taranto, Concetta Sica, Antonio Boscia, Francesco Papagni, Giuliana Fortunato, Gaetano Corso, Antonio Dello Russo   +7 more
doaj   +5 more sources

Genetic analysis of indicators of cholesterol synthesis and absorption: Lathosterol and phytosterols in Dutch twins and their parents [PDF]

Twin Research, 2003
Significant familial aggregation was observed for plasma levels of lathosterol (an indicator of whole-body cholesterol synthesis) and plant sterols campesterol and β-sitosterol (indicators of cholesterol absorption) in 160 Dutch families consisting of ...
Boomsma, D.I., Frants, R.R., Gevers Leuven, J.A., Kempen, H.J.M., Princen, H.M.G.   +4 more
core   +6 more sources

Functional Segregation of Pancreatic Microcirculation Reveals Sex‐Dependent Microhemodynamic Signatures [PDF]

Compr Physiol
Pancreatic exocrine microcirculation exhibits sexual dimorphism arising from steroid–genetic interactions. Laser Doppler flowmetry combined with wavelet analysis identifies a male passive coupling phenotype aligned with systemic pressure and a female active vasomotion phenotype driven by ERβ‐mediated, NO‐dependent oscillations.
Li Y, Wang Y, Wang B, Ouyang Q, Liu W, Xu X, Zhang X, Liu M, Xiu R.   +8 more
europepmc   +2 more sources

Neuronal Damage Induced by Gradual Oxidative Stress in iPSC-Derived Neurons: Implications for Ferroptosis Involvement and ALS Drug Evaluation. [PDF]

J Neurochem
The authors induced damage in iPSC‐derived motor neurons through gradual oxidative stress by culturing them without antioxidants. Neurons underwent ferroptosis‐dependent cell death, which was inhibited by edaravone. Additionally, the authors revealed neuroprotective activity in a cholesterol metabolite and a sterol pathway inhibitor, suggesting that ...
Kobayashi H, Suzuki-Masuyama H, Tanabe H, Kato H, Endoh-Yamagami S.   +4 more
europepmc   +2 more sources

Effect of Desmosterol, Lathosterol and Coprostanol on the Phase Behaviour of Phospholipid Membranes

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2023
Sterols have played an important role in membrane evolution. The effect of these molecules, particularly the naturally occurring ones, such as cholesterol, ergosterol, lanosterol, phytosterols and oxysterols on the prop-erties of lipid model membranes have been extensively investigated.
Md. Arif Kamal, Antara Pal
openaire   +3 more sources

Plasma Cholesterol and Lathosterol Levels in Term Infants in the Early Neonatal Period [PDF]

Pediatric Research, 1992
Plasma cholesterol concentrations increase after birth. Whether this is due to increased cholesterol synthesis has not been reported. Additionally, it is not known if formulas, which lack cholesterol, result in higher rates of cholesterol synthesis than feeding breast milk.
J J, Hamilton, A, Synnes, S M, Innis
openaire   +2 more sources

Effects of ezetimibe on cholesterol metabolism in HIV-infected patients with protease inhibitor-associated dyslipidemia: a single-arm intervention trial [PDF]

, 2018
BACKGROUND: The effects of ezetimibe on cholesterol metabolism in HIV-infected patients receiving boosted protease inhibitors have not been thoroughly assessed.
Cofán Pujol, Montserrat, Forga, María T., Larrousse Morellón, Maria, Leyes, Pere, Martínez Chamorro, Esteban José, Pérez-Heras, Ana Maria, Ros Rahola, Emilio, Trabal, Joan   +7 more
core   +1 more source

Defective conversion of 7-dehydrocholesterol to cholesterol in cultured skin fibroblasts from Smith-Lemli-Opitz syndrome homozygotes

Journal of Lipid Research, 1995
The Smith-Lemli-Opitz syndrome is a common birth defect syndrome characterized biochemically by low plasma cholesterol levels and high concentrations of the cholesterol precursor 7-dehydrocholesterol.
A Honda, G S Tint, G Salen, A K Batta, T S Chen, S Shefer   +5 more
doaj   +1 more source

Sterol profiles in plasma and erythrocyte membranes in patients with Smith-Lemli-Opitz syndrome: a six-year experience [PDF]

, 2011
Background: This study reports our experience over the last six years in the diagnosis of Smith-Lemli-Opitz syndrome and other inborn errors of cholesterol biosynthesis.
A. Nappi, DELLO RUSSO, ANTONIO, G. Corso, GELZO, MONICA, P. Pianese, R. Barone, S. Clericuzio   +6 more
core   +1 more source

Sialic acid content of low density lipoprotein and its relation to lipid concentrations and metabolism of low density lipoprotein and cholesterol

Journal of Lipid Research, 2000
A low sialic acid content in low density lipoprotein (LDL) has been associated with atherogenicity and coronary artery disease (CAD) in many but not all studies. We investigated associations of the sialic acid-to-apolipoprotein B (apoB) ratio of LDL with
Nina Lindbohm, Helena Gylling, Tatu A. Miettinen   +2 more
doaj   +1 more source