Results 51 to 60 of about 2,855 (207)

Studies in hypertriglyceridaemia VI: serum lathosterol concentration is raised in hypertriglyceridaemic non‐diabetic males with hyperinsulinaemia [PDF]

Journal of Internal Medicine, 1999
Abstract.Objectives. To assess the cholesterol synthesis rate in primary hypertriglyceridaemia using the serum unesterified lathosterol concentration as an indicator.Design. A cross‐sectional, case–control study.Setting. The Karolinska Hospital, Stockholm.Subjects. Randomly selected hyper‐ (n = 53) and normotriglyceridaemic (n = 57) males, 40–50 years,
A, Asplund-Carlson, E, Lund, I, Björkhem, L A, Carlson   +3 more
openaire   +2 more sources

High cholesterol absorption efficiency enhances proatherogenic properties of low‐density lipoprotein particles

Journal of Internal Medicine, EarlyView.
Abstract Background and Aims High cholesterol absorption efficiency is determined by genetic variation in small intestinal sterol transporters and affects one‐third of individuals. Their risk for atherosclerotic cardiovascular disease (ASCVD) is increased compared with low cholesterol absorbers, despite similar serum lipid concentrations.
Katariina Öörni, Lauri Äikäs, Maija Ruuth, Feven Tigistu‐Sahle, Reijo Käkelä, Ingmar Wester, Helena Gylling, Piia Simonen   +7 more
wiley   +1 more source

Association between cholesterol synthesis/absorption markers and effects of cholesterol lowering by atorvastatin among patients with high risk of coronary heart disease[S]

Journal of Lipid Research, 2013
No indices are currently available to facilitate clinicians to identify patients who need either statin monotherapy or statin-ezetimibe combined treatment.
Yue Qi, Jing Liu, Changsheng Ma, Wei Wang, Xiaohui Liu, Miao Wang, Qiang Lv, Jiayi Sun, Jun Liu, Yan Li, Dong Zhao   +10 more
doaj   +1 more source

Mapping molluscan endocrinology: a systematic and critical appraisal

Biological Reviews, Volume 101, Issue 2, Page 970-1002, April 2026.
ABSTRACT Historically, a vertebrate‐centric paradigm has framed our interpretation of molluscan endocrinology, with considerable research focusing on vertebrate‐type steroid hormones (e.g. oestrogens, testosterone). However, contradictory evidence on the occurrence of vertebrate‐type steroid hormones in molluscan tissues, and a lack of the specific ...
Konstantinos Panagiotidis, Thomas H. Miller, Olwenn V. Martin, Alice Baynes   +3 more
wiley   +1 more source

The relationships of cholesterol metabolism and plasma plant sterols with the severity of coronary artery disease1s⃞

Journal of Lipid Research, 2009
Changes in the balance of cholesterol absorption and synthesis and moderately elevated plasma plant sterols have been suggested to be atherogenic. Measuring cholestanol, lathosterol, campesterol, and sitosterol, we investigated the relationships of ...
Guenther Silbernagel, Guenter Fauler, Wilfried Renner, Eva M. Landl, Michael M. Hoffmann, Bernhard R. Winkelmann, Bernhard O. Boehm, Winfried März   +7 more
doaj   +1 more source

Use of determinations of 7-lathosterol (5 alpha-cholest-7-en-3 beta-ol) and other cholesterol precursors in serum in the study and treatment of disturbances of sterol metabolism, particularly cerebrotendinous xanthomatosis

Journal of Lipid Research, 1991
The sterol composition of sera from patients with cerebrotendinous xanthomatosis (CTX) was investigated by gas chromatographic analysis of saponified extracts, using a polar (CP Wax 52CB) and an apolar (CP Sil 5CB) capillary column.
BG Wolthers, HT Walrecht, JC van der Molen, GT Nagel, JJ Van Doormaal, PN Wijnandts   +5 more
doaj   +1 more source

Direct analysis of sterols from dried plasma/blood spots by an atmospheric pressure thermal desorption chemical ionization mass spectrometry (APTDCI-MS) method for a rapid screening of Smith-Lemli-Opitz syndrome. [PDF]

, 2010
Here is proposed a rapid and sensitive method involving atmospheric pressure thermal desorption chemical ionization mass spectrometry (APTDCI-MS) for specific laboratory screening of the Smith– Lemli–Opitz syndrome (SLOS), an inherited defect of ...
Corso G., D'Apolito O., Dello Russo A., Gelzo M., Paglia G.   +4 more
core   +1 more source

Reprogramming SREBP1‐dependent lipogenesis and inflammation in high‐risk breast with licochalcone A: A novel path to cancer prevention

International Journal of Cancer, Volume 158, Issue 7, Page 1927-1940, 1 April 2026.
What's new? Endocrine drugs repurposed from treatment protocols are the primary medications available for breast cancer (BC) prevention in at‐risk women. Adverse effects, however, significantly minimize uptake and prevention impact. Here, the authors investigated licochalcone A (LicA), a non‐endocrine anti‐inflammatory agent with reported hematologic ...
Atieh Hajirahimkhan, Elizabeth T. Bartom, Carolina H. Chung, Xingyu Guo, Kyli Berkley, Seyyedmohsen Hosseinibarkooie, Zahra Assadi, Shao Huan Samuel Weng, Raymond Moellering, Oukseub Lee, Ruohui Chen, Wonhwa Cho, Sriram Chandrasekaran, Susan E. Clare, Seema A. Khan   +14 more
wiley   +1 more source

The lipid-lowering effect of ezetimibe in pure vegetarians

Journal of Lipid Research, 2006
Results of previous studies have shown that ezetimibe (10 mg/day) reduces LDL cholesterol in patients with mild hypercholesterolemia on a normal-cholesterol diet (dietary intake of 200–500 mg/day) by 16–22%.
Jacob J. Clarenbach, Michael Reber, Dieter Lütjohann, Klaus von Bergmann, Thomas Sudhop   +4 more
doaj   +1 more source

Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents [PDF]

, 2011
Background During the past decade, proprotein convertase subtilisin kexin type 9 (PCSK9) has been identified as a key regulator of serum LDL-cholesterol (LDL-C) levels.
Robert J Konrad, Jason S Troutt, Guoqing Cao   +2 more
core   +2 more sources