Results 61 to 70 of about 2,855 (207)

A Cluster of Three snoRNAs Including Jouvence Required in the Gut Determines Lifespan and Confers Neuroprotection Through Metabolic Parameters

Aging Cell, Volume 25, Issue 4, April 2026.
The disruption of a cluster of three snoRNAs in the epithelium of the gut deregulates the lipid and sterol (including the cholesterol) homeostasis. At the whole‐organism level, this chronic deregulation, all along life, decreases lifespan and leads to neurodegenerative lesions in old flies.
Sara Al Issa, Théo Gauvrit, Patricia Daira, Nathalie Bernoud‐Hubac, Jean‐René Martin   +4 more
wiley   +1 more source

Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism

Journal of Lipid Research, 2007
Nine hypercholesterolemic and hypertriglyceridemic subjects were enrolled in a randomized, placebo-controlled, double-blind, crossover study to test the effect of atorvastatin 20 mg/day and 80 mg/day on the kinetics of apolipoprotein B-100 (apoB-100) in ...
Stefania Lamon-Fava, Margaret R. Diffenderfer, P. Hugh R. Barrett, Aaron Buchsbaum, Nirupa R. Matthan, Alice H. Lichtenstein, Gregory G. Dolnikowski, Katalin Horvath, Bela F. Asztalos, Valeria Zago, Ernst J. Schaefer   +10 more
doaj   +1 more source

Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism [PDF]

, 2014
The mechanism of antihypertensive and lipid-lowering drugs on the human organism is still not fully understood. New insights on the drugs' action can be provided by a metabolomics-driven approach, which offers a detailed view of the physiological ...
Barbara Thorand, Christian Gieger, Christine Meisinger, Elisabeth Altmaier, Gabi Kastenmüller, Gisela Fobo, Jerzy Adamski, Karsten Suhre, Margit Heier, Melanie Waldenberger, Thomas Illig, Werner Römisch-Margl   +11 more
core   +2 more sources

Glycoalkaloid‐Free Starch Potatoes Generated by CRISPR/Cas9‐Mediated Mutations of Genes in the Glycoalkaloid Biosynthesis Pathway Enable More Sustainable Uses of By‐Products From Starch Production

Plant Biotechnology Journal, Volume 24, Issue 3, Page 1344-1358, March 2026.
ABSTRACT Steroidal glycoalkaloids (SGAs) are toxic cholesterol‐derived secondary metabolites present in several Solanaceae species. In potato, tuber SGA levels are for reasons of toxicity of concern in both table and starch cultivars. In the latter, SGAs bind to proteins and fibres in starch production side‐streams and prevent their further uses as ...
Ying Liu, Irene Merino, Mareike Gutensohn, Annika I. Johansson, Kalle Johansson, Mariette Andersson, Per Hofvander, Folke Sitbon   +7 more
wiley   +1 more source

Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity: lessons from the METSIM Study1

Journal of Lipid Research, 2010
Cholesterol synthesis is upregulated and absorption downregulated in insulin resistance and in type 2 dia-betes. We investigated whether alterations in cholesterol metabolism are observed across the glucose tolerance status, from normoglycemia through ...
Helena Gylling, Maarit Hallikainen, Jussi Pihlajamäki, Piia Simonen, Johanna Kuusisto, Markku Laakso, Tatu A. Miettinen   +6 more
doaj   +1 more source

Studies on PCSK9 in the regulation of cholesterol metabolism [PDF]

, 2011
Elevated levels of plasma cholesterol, mainly in low density lipoproteins (LDL), are a major risk factor for coronary heart disease. The level of plasma LDL cholesterol (LDL-C) is largely dependent on the number of hepatic LDL receptors (LDLRs ...
Persson, Lena
core   +1 more source

NUDT21‐mediated Alternative Polyadenylation of CDK19 Reprograms Cholesterol Biosynthesis to Drive Colorectal Cancer Progression

Advanced Science, Volume 13, Issue 7, 3 February 2026.
NUDT21 is overexpressed in colorectal cancer tumors and promotes colorectal cancer progression. NUDT21 promotes the production of a cyclin‐dependent kinase 19 (CDK19) mRNA isoform with a long 3′ UTR, which enhances cytoplasmic export and translation. Truncation of the CDK19 long 3′ UTR phenocopies NUDT21 loss, recapitulating the defects in cholesterol ...
Yeping Yu, Jixin Ma, Minwei Zhou, Xiaodong Gu, Yiming Zhou, Zhenyang Li, Tianyu Zhang, Wei Gong, Chuanxin Huang, Jianbin Xiang   +9 more
wiley   +1 more source

Alterations in cholesterol absorption/synthesis markers characterize Framingham Offspring Study participants with CHD[S]

Journal of Lipid Research, 2009
Data is limited on measures influencing cholesterol homeostasis in subjects at high risk of developing cardiovascular disease (CVD) relative to established risk factors.
Nirupa R. Matthan, Michael Pencina, Jane M. LaRocque, Paul F. Jacques, Ralph B. D'Agostino, Ernst J. Schaefer, Alice H. Lichtenstein   +6 more
doaj   +1 more source

Infection with the hepatitis C virus causes viral genotype-specific differences in cholesterol metabolism and hepatic steatosis

Scientific Reports, 2022
Lipids play essential roles in the hepatitis C virus (HCV) life cycle and patients with chronic HCV infection display disordered lipid metabolism which resolves following successful anti-viral therapy.
David A. Sheridan, Isaac Thom Shawa, E. Louise Thomas, Daniel J. Felmlee, Simon H. Bridge, Dermot Neely, Jeremy F. Cobbold, Elaine Holmes, Margaret F. Bassendine, Simon D. Taylor-Robinson   +9 more
doaj   +1 more source

The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts [PDF]

, 2018
K
Balogh, István, Kim, Hye-Young H., Koczok, Katalin, Korade, Zeljka, Liu, Wei, Mirnics, Károly, Porter, Ned A., Tallman, Keri A., Xu, Libin   +8 more
core   +1 more source