Results 61 to 70 of about 277,444 (259)

Genomic view of heavy-ion-induced deletions associated with distribution of essential genes in Arabidopsis thaliana

Frontiers in Plant Science
Heavy-ion beam, a type of ionizing radiation, has been applied to plant breeding as a powerful mutagen and is a promising tool to induce large deletions and chromosomal rearrangements. The effectiveness of heavy-ion irradiation can be explained by linear
Kotaro Ishii, Kotaro Ishii, Yusuke Kazama, Yusuke Kazama, Tomonari Hirano, Tomonari Hirano, Jeffrey A. Fawcett, Muneo Sato, Masami Yokota Hirai, Masami Yokota Hirai, Fujiko Sakai, Yuki Shirakawa, Sumie Ohbu, Tomoko Abe   +13 more
doaj   +1 more source

Beyond Förster Resonance Energy Transfer in Linear Nanoscale Systems

The Journal of Physical Chemistry A, 2010
The line dipole approximation is used to investigate analytical corrections to the Förster energy transfer rate, k, derived via the point dipole approximation. It is shown that that for molecules whose conjugation length, L, is much larger than the separation, R, between molecules the line dipole approximation predicts k ~ (RL)⁻² ~ (RN)⁻² (where N is ...
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Influence of Wave Nonlinearity on Cross-Shore Sediment Transport in Coastal Zone: Experimental Investigations

Applied Sciences, 2020
On the basis of field experiment data, the main features of influence of non-linear wave transformation scenarios on cross-shore sediment transport in coastal zones were investigated.
Yana Saprykina
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Optimal dephasing for ballistic energy transfer in disordered linear chains

Physical Review E, 2017
16 pages, inlcuding 9 ...
Zhang, Yang, Celardo, Giuseppe Luca, Borgonovi, Fausto, Kaplan, Lev   +3 more
openaire   +5 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Medical radiation countermeasures for nuclear and radiological emergencies: Current status and future perspectives

Journal of Pharmacy and Bioallied Sciences, 2010
Nuclear and radiological emergencies (NREs) occurred globally and recent incidences in India are indicating toward the need for comprehensive medical preparedness required both at incident site and hospitals.
Rajesh Arora, Raman Chawla, Rohit Marwah, Vinod Kumar, Rajeev Goel, Preeti Arora, Sarita Jaiswal, Rakesh Kumar Sharma   +7 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source