Results 71 to 80 of about 2,488,943 (332)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

pyMKM: An Open-Source Python Package for Microdosimetric Kinetic Model Calculation in Research and Clinical Applications

open access: yesComputation
Among existing radiobiological models, the MKM and its extensions (SMK and OSMK) have demonstrated strong predictive capabilities but remain computationally demanding.
Giuseppe Magro   +5 more
doaj   +1 more source

Density Functional Extension to Excited-State Mean-Field Theory. [PDF]

open access: yes, 2019
We investigate an extension of excited-state mean-field theory in which the energy expression is augmented with density functional components in an effort to include the effects of weak electron correlations. The approach remains variational and entirely
Neuscamman, Eric, Zhao, Luning
core   +2 more sources

Relating Linear Energy Transfer to the Formation and Resolution of DNA Repair Foci After Irradiation with Equal Doses of X-ray Photons, Plateau, or Bragg-Peak Protons

open access: yesInternational Journal of Molecular Sciences, 2018
Proton beam therapy is increasingly applied for the treatment of human cancer, as it promises to reduce normal tissue damage. However, little is known about the relationship between linear energy transfer (LET), the type of DNA damage, and cellular ...
S. Oeck   +8 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Monitor of the single event upsets and linear energy transfer of space radiation on the Beidou navigation satellites

open access: yesOpen Astronomy, 2023
The single event effect caused by space heavy ion radiation is one of the important factors affecting the safety and operation of spacecraft on orbit.
Zhang Binquan   +10 more
doaj   +1 more source

New model of calculating the energy transfer efficiency for the spherical theta-pinch device

open access: yes, 2015
Ion-beam-plasma-interaction plays an important role in the field of Warm Dense Matter (WDM) and Inertial Confinement Fusion (ICF). A spherical theta pinch is proposed to act as a plasma target in various applications including a plasma stripper cell. One
Hock, C.   +7 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Parameters design for a non-linear absorber based on phase trajectory analysis

open access: yesThe Journal of Engineering, 2018
The performance of non-linear absorbers for suppression of the structure vibrations depends on the setting of the absorbers' parameters to a certain extent.
Yuan Liu, Feng Wang, Dedong Han
doaj   +1 more source

Comparison of the Dynamic Performance of Planar 3-DOF Parallel Manipulators

open access: yesMachines, 2022
This paper presents a comprehensive comparison study on the dynamic performances of three planar 3-DOF parallel manipulators (PPMs): 3-RRR, 3-PRR, and 3-RPR.
Guoning Si, Fahui Chen, Xuping Zhang
doaj   +1 more source

Home - About - Disclaimer - Privacy