Results 61 to 70 of about 10,676,082 (292)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Parameters design for a non-linear absorber based on phase trajectory analysis

The Journal of Engineering, 2018
The performance of non-linear absorbers for suppression of the structure vibrations depends on the setting of the absorbers' parameters to a certain extent.
Yuan Liu, Feng Wang, Dedong Han
doaj   +1 more source

Monitor of the single event upsets and linear energy transfer of space radiation on the Beidou navigation satellites

Open Astronomy, 2023
The single event effect caused by space heavy ion radiation is one of the important factors affecting the safety and operation of spacecraft on orbit.
Zhang Binquan, Zhang Shenyi, Shen Guohong, Tuo Changsheng, Zhang Xin, Zhang Huanxin, Quan Lin, Tian Chao, Hou Donghui, Zhou Ping, Ji Wentao   +10 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Assessment of Tumor Relative Biological Effectiveness in Low-LET Proton Irradiation

Biomedicines
Background/Objectives: Within the range of spread-out Bragg peak (SOBP), LET (linear energy transfer) gradually increases from proton beam entrance point toward the beam exit direction.
Ying-Chun Lin, Jiamin Mo, Yuan-Hao Lee
doaj   +1 more source

linear energy transfer

, 2014
Citation: 'linear energy transfer' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.L03550 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

High linear-energy-transfer radiation can overcome radioresistance of glioma stem-like cells to low linear-energy-transfer radiation [PDF]

Journal of Radiation Research, 2013
Ionizing radiation is applied as the standard treatment for glioblastoma multiforme (GBM). However, radiotherapy remains merely palliative, not curative, because of the existence of glioma stem cells (GSCs), which are regarded as highly radioresistant to low linear-energy-transfer (LET) photons.
Hirota, Yuki, Masunaga, Shin-Ichiro, Kondo, Natsuko, Kawabata, Shinji, Hirakawa, Hirokazu, Yajima, Hirohiko, Fujimori, Akira, Ono, Koji, Kuroiwa, Toshihiko, Miyatake, Shin-Ichi   +9 more
openaire   +2 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Medical radiation countermeasures for nuclear and radiological emergencies: Current status and future perspectives

Journal of Pharmacy and Bioallied Sciences, 2010
Nuclear and radiological emergencies (NREs) occurred globally and recent incidences in India are indicating toward the need for comprehensive medical preparedness required both at incident site and hospitals.
Rajesh Arora, Raman Chawla, Rohit Marwah, Vinod Kumar, Rajeev Goel, Preeti Arora, Sarita Jaiswal, Rakesh Kumar Sharma   +7 more
doaj   +1 more source